職名 講師
氏名 しまだ やすひと
島田 康人
生年月 1971.04
所属 部局 医学系研究科
学科・専攻 生命医科学専攻
講座 基礎医学系講座
教育研究分野  
TEL 059-231-5384 (内線6906)
FAX 059-232-1765
E-mail shimada.yasuhito@ (末尾に mie-u.ac.jp を補ってください)
個人のホームページ http://yshimada.jp/
学歴 三重大学医学部 学士課程 (~1999年)
三重大学大学院医学系研究科 博士課程・博士後期課程 (2000年04月01日~2004年03月31日)
学位 2013.03 博士 三重大学
所属学会 日本薬理学会 日本生化学会 日本心脈管作動物質学会 日本ケミカルバイオロジー学会 日本循環薬理学会 日本分子生物学会
社会活動  
職歴 1999.06~1999.08 国立療養所榊原病院 医師 研修医
1999.09~1999.11 三重県立こころの医療センター 研修医
1999.12~2000.05 三重大学医学部附属病院精神神経科 研修医
2000.06~2001.05 三重県立総合医療センター精神神経科 嘱託医
2004.04~2004.08 三重大学医学部 教務職員
2004.09~ 三重大学大学院医学系研究科薬理ゲノミクス分野 助教
2005.04~ 三重大学生命科学研究支援センター機能ゲノミクス分野 助教
2014.04~2016.03 ライデン大学 客員研究員
2016.04~ 三重大学大学院医学系研究科統合薬理学分野 講師
2016.04~ 三重大学生命科学研究支援センターバイオインフォマティクス部門 講師
2017.11~ 三重大学卓越型リサーチセンター センター長
学術(芸術)賞 第17回日本循環薬理学会,Young Investigator's Award賞受賞,2007.11,日本循環薬理学会
三重大学知的財産優秀賞,2015.09,三重大学
専門分野 薬理ゲノミクス・バイオインフォマティクス
現在の研究課題 肥満・癌モデルゼブラフィッシュを用いた創薬研究
担当科目 生体防御の分子基盤 分子医学実習 分子生命体科学
主な業績等 論文(過去3年分、国際雑誌のみ記載)
54. Shimada Y*, Hazekawa M. Developing a model for a siRNA delivery system by cancer implantation into zebrafish circulation. Methods Mol Biol. 2019;in press. - First and corresponding author.
53. Yamada Y, Chensom S, Yonemoto H, Nakayama H, Zang L, Nishimura N, Mishima T, Shimada Y*. Water extract of Yamato-Tachibana (Citrus tachibana) induces food intake in adult and larval zebrafish. J Med Food. 2019; [Epub ahead of print]. - Corresponding author.
52. Sawaki R, Sato D, Nakayama H, Nakagawa Y, Shimada Y*. ZF-AutoML: An easy machine learning-based method to detect anomalies in fluorescent-labelled zebrafish. Inventions. 2019;4:72. - Corresponding author.
51. Hu W, Yang S, Shimada Y, Münch M, Marín-Juez R, Meijer AH, Spaink HP. Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this Toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection. BMC Genomics. 2019;20:878.
50. Zang L, Shimada Y, Nakayama H, Kim Y, Chu D, Juneja LR, Kuroyanagi J, Nishimura N. RNA-seq based transcriptome analysis of the anti-obesity effect of green tea extract using zebrafish obesity models. Molecules. 2019;24:3256.
49. Monma Y, Shimada Y, Nakayama H, Zang L, Nishimura N, Tanaka T. Aging-associated microstructural deterioration of vertebra in zebrafish. Bone Rep. 2019;11:100215.- Equally contributed first author.
48. Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N. Therapeutic silencing of centromere protein X ameliorates hyperglycemia in zebrafish and mouse models of type 2 diabetes mellitus. Front Genet. 2019;10:693.
47. Kawada T, Kuroyanagi J, Okazaki F, Taniguchi T, Suda N, Abiko S, Kaneco S, Nishimura N, Shimada Y*. An Integrative Evaluation Method for the Biological Safety of Down and Feather Materials.Int J Mol Sci. 2019;20:1434. - Corresponding author.
46. Vranic S, Shimada Y*, Ichihara S*, Kimata M, Wu W, Tanaka T, Boland S, Tran L, Ichihara G. Toxicological evaluation of SiO2 nanoparticles by zebrafish embryo toxicity test. Int J Mol Sci. 2019;20:882. - Equally contributed first author.
45. Yamamoto D, Sato D, Nakayama H, Nakagawa Y, Shimada Y*. ZF-Mapper: Simple and Complete Freeware for Fluorescence Quantification in Zebrafish Images. Zebrafish. 2019; in press. - Corresponding author.
44. Okazaki F, Zang L, Nakayama H, Chen Z, Gao Z, Chiba H, Hui S, Aoki T, Nishimura N, Shimada Y*. Microbiome Alteration in Type 2 Diabetes Mellitus Model of Zebrafish. Sci Rep. 2018; in press. *equally contributed first and corresponding author.
43. Nakayama H, Shimada Y*, Zang L, Terasawa M, Nishiura K, Matsuda K, Toombs C, Langdon C, Nishimura N. A novel anti-obesity properties of Palmaria mollis in zebrafish and mouse models. Nutrients. 2018;10:1401. *equally contributed first and corresponding author.
42. Chen Z, Wu Y, Zang L, Shimada Y, Nakayama H, Rojeet S, Zhao Y, Miura Y, Nishimura N, Chiba H, Hui S. Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish. Anal Sci. 2018;34:1201-1208.
41. Yang J, Meng Z, Liu Q, Shimada Y, Olsthoorn RC, Spaink HP, Herrmann A, Kros A. Performing DNA Nanotechnology Operations on a Zebrafish. Chem Sci. 2018;9:7271-7276.
40. Nakayama H, Katayama K, Onabe Y, Sato A, Nishimura N, Shimada Y. Dried Rotifer Sheet: A Novel Live Feed for Rearing First-Feeding Larvae. Zebrafish. 2018;15:291-294. *equally contributed first and corresponding author.
39. Zang L, Shimada Y, Nishimura N. Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. Sci Rep. 2017;7:1461. *equally contributed first author.
38. Ashikawa Y, Nishimura Y, Okabe S, Sato Y, Yuge M, Tada T, Miyao H, Murakami S, Kawaguchi K, Sasagawa S, Shimada Y, Tanaka T. Protective function of the sterol regulatory element binding factor 1–fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Heliyon. 2017;3:3.
37. Yang J, Shimada Y*, Olsthoorn RC, Snaar-Jagalska BE, Spaink HP, Kros A. Application of Coiled Coil Peptides in Liposomal Anti-Cancer Drug Delivery Using a Zebrafish Xenograft Model. ACS Nano. 2016;10:7428-7435. *equally contributed first and corresponding author
36. Inoue A, Nishimura Y, Matsumoto N, Umemoto N, Shimada Y, Maruyama T, Kayasuga K, Morihara M, Katagi J, Shiroya T, Hirota Y, Kim S, Tanaka T. Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs. Fundam. Toxicol. Sci. 2016;3:79-87.
35. Zhang B, Shimada Y*, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Transl Res. 2016;170:89-98 *equally contributed first author.


学会発表(過去3年分、国際学会のみ記載)
2019/9/20-22, Qingdao, China
BIT's 8th Annual World Congress of Food and Nutrition-2019
- Zebrafish as a Model for Screening Anti-obesity Natural Products. Zang L, Shimada Y, Juneja L, Segi H, Kim Y, Nishimura N.
- The red seaweed, Palmaria mollis, suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish and mice. Shimada Y, Yamakawa M, Nakayama H, Zang L, Terasawa M, Nishimura K, Nishimura N.

2019/8-19-20, Valencia, Spain
3rd World Conference on Food science, Nutrition and Obesity Prevention Source
- Zebrafish model for human intestinal microbiome in Type 2 Diabetes Mellitus. Shimada Y, Okazaki F, Zang L, Nakayama H, Chen Z, Gao Z, Chiba H, Hui S, Nishimura N.
- Zebrafish as a Model for Screening Anti-obesity Natural Products. Zang L, Shimada Y, Juneja L, Segi H, Kim Y, Nishimura N.
- Discovery of anti-obese fucoxanthin in Palmaria mollis using zebrafish obesogenic test. Yamakawa M, Masuda Y, Nakayama H, Zang L, Terasawa M, Nishimura K, Nishimura N, Shimada Y.

2018/12/16-19 British Ecological Society Annual Meeting 2018
- Detection of Zebrafish messenger RNAs from tank water: implications for the practicability of environmental RNA analysis for aquatic macroorganisms. Yamanaka H, Tsuri K, Ikeda S, Shimada Y, Minamoto T.

2018/7/10-13 ZDM11 - Zebrafish Disease Models Society
- Microbiome Alteration in Type 2 Diabetes Mellitus Model of Zebrafish. Shimada Y, Okazaki F, Zang L, Nakayama H, Nishimura N.
- Anticancer Drug Discovery using Zebrafish Allograft Model: Repositioning of Flubendazole for the treatment for Melanoma. Kinoshita G, Yamada E, Nakayama H, White R, Nishimura N, Snaar-Jagalska E, Spaink H, Shimada Y.
- Dried Rotifer Sheet: a novel live feed for rearing first-feeding larvae. Nakayama H, Onabe Y, Sato S, Nishimura N, Shimada Y.
- Palmaria mollis exerts anti-obesity effects in zebrafish and mice by inhibiting lipogenesis and promoting lipolysis. Zang L, Nakayama H, Shimada Y, Terasawa M, Nishiura K, Matsuda K, Toombs C, Langdon C, Nishimura N.

2018/7/1-5 18th World Congress of Basic and Clinical Pharmacology
- Marine Drug Discovery: Anti-obesity Mechanism of Palmaria mollis in Zebrafish and Mice. Shimada Y, Nakayama H, Zang L, Terasawa K, Matsuda K, Nishiura K, Toombs C, Langdon C, Nishimura N.
- Cross-species Discovery of Flubendazole against Melanoma Progression via MITF and EMT inhibition. Kinoshita G, Yamada E, Nakayama H, White R, Snaar-Jagalsk E, Spaink H, Shimada Y.
- Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. Zang L, Shimada Y, Nishimura N.

2017/10/18-19 International Symposium on Novel and Sustainable Technology(招待講演)
- Zebrafish in Drug Discovery: Disease Models and Chemical Screening for Obesity and Cancer Research. Shimada Y.

2017/8/6 The 10th Zebrafish Disease Models Meeting
- Anti-Cancer Drug Delivery using Supramolecular Coiled-Coil Peptides Formation in Zebrafish Xenograft Model. Shimada Y, Yang J, Olsthoon R, Snaar-Jagalska E, Spaink H, Nishimura Y, Kros A.
- Zebrafish - a powerful tool to assess anti-obesity effects of natural products. Zang L, Shimada Y, Nishimura N.

2017/6/16 2017 Midwest Zebrafish Meeting
- Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. Zang L, Shimada Y, Nishimura N.

2017/3/12 Society of Toxicology, 56th Annual Meeting
- Lck inhibitor dose not induce ocular toxicity in both zebrafish and rat. Inoue A, Nishimura Y, Umemoto N, Shimada Y, Maruyama T, Morihara M, Kim S, Tanaka T.

2016/11/12 Society for Neuroscience, 2016 Annual Meeting
- E2F4 promotes recovery after spinal cord injury in zebrafish. Sasagawa S, Nishimura Y, Hayakawa Y, Murakami S, Ashikawa Y, Yuge M, Okabe S, Kawaguchi K, Kawase R, Shimada Y, Tanaka T.
- Pharmacological profiling of zebrafish sleep-awake states. Nishimura Y, Okabe S, Sasagawa S, Murakami S, Ashikawa Y, Yuge M, Kawaguchi K, Kawase R, Shimada Y, Tanaka T.

2016/10/5-6 The 9th Zebrafish Disease Models Conference
- Diet-induced Obesity Model for Natural Products Drug Discovery. Shimada Y, Zang L, Nishimura N, Tanaka T.
- Creation of Novel Zebrafish Model for Type 2 Diabetes Mellitus. Zang L, Shimada Y, Nishimura N.

2016/6/15 ICCA-LRI and NIHS Workshop
- Development of in vivo fluorescent imaging of neuronal differentiation in zebrafish for developmental neurotoxicity testing. Nishimura Y, Ashikawa Y, Sasagawa S, Murakami S, Yuge M, Sato Y, Tada T, Okabe S, Kawaguchi K, Shimada Y, Tanaka T.