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三重大学教員紹介

教員情報

職名
講師
氏名
しまだ やすひと
島田 康人
生年月
1971.04
所属
部局
医学系研究科
学科・専攻
生命医科学専攻
講座
基礎医学系講座
教育研究分野
 
TEL
059-232-1111(内線6343)
FAX
059-246-7739
E-mail
cobo2@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
学歴
三重大学医学部 学士課程 (~1999年)
三重大学大学院医学系研究科 博士課程・博士後期課程 (2000年04月01日~2004年03月31日) 満了
学位
2013.03 博士 三重大学
所属学会
日本薬理学会 日本生化学会 日本心脈管作動物質学会 日本ケミカルバイオロジー学会 日本循環薬理学会 日本分子生物学会
社会活動
 
職歴
1999.06~1999.08 国立療養所榊原病院 医師 研修医
1999.09~1999.11 三重県立こころの医療センター 医師 研修医
1999.12~2000.05 三重大学医学部附属病院精神神経科 医師 研修医
2000.06~2001.05 三重県立総合医療センター精神神経科 医師 嘱託医
2004.04~2004.08 三重大学医学部 教員 教務職員
2004.09~ 三重大学大学院医学系研究科薬理ゲノミクス分野 教員 助教
2005.04~ 三重大学生命科学研究支援センター機能ゲノミクス分野 教員 助教
2014.04~2016.03 ライデン大学 客員研究員 客員研究員
2016.04~ 三重大学大学院医学系研究科薬理ゲノミクス分野 教員 講師
2016.04~ 三重大学生命科学研究支援センターバイオインフォマティクス部門 教官 講師
学術(芸術)賞
第17回日本循環薬理学会,Young Investigator's Award賞受賞,2007.11,日本循環薬理学会
三重大学知的財産優秀賞,2015.09,三重大学
専門分野
薬理ゲノミクス・バイオインフォマティクス
現在の研究課題
ヒト疾患モデルゼブラフィッシュを用いた創薬研究
担当科目
PBLチュートリアル 分子医学実習 薬理学
主な業績等
1. Inoue A, Nishimura Y, Matsumoto N, Umemoto N, Shimada Y, Maruyama T, Kayasuga K, Morihara M, Katagi J, Shiroya T, Hirota Y, Kim S, Tanaka T. Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs. Fundam. Toxicol. Sci. 2016 3:79-87

2. Zhang B, Shimada Y*, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Transl Res. 2016 170: 89-98 *equally contributed first author

3. Nishimura Y, Sasagwa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T.Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Front Pharmacol. 2015 6: 19

4. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. Repeated Blood Collection for Blood Tests in Adult Zebrafish. J. Vis. Exp. 2015 102: e53272

5. Zang L, Shimada Y, Tanaka T and Nishimura Y. Rhamnan sulphate from Monostroma nitidum attenuates hepatic steatosis by suppressing lipogenesis in a diet-induced obesity zebrafish model. J Funct Foods. 2015 17: 364-370.

6. Shimada Y, Kuninaga S, Ariyoshi M, Zhang B, Shiina Y, Takahashi Y, Umemoto N, Nishimura Y, Enari H and Tanaka T. E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. Nutr Metab. 2015 12:17

7. Zhang B, Shimada Y*, Kuroyanagi J, Ariyoshi M, Nomoto T, Shintou T, Umemoto N, Nishimura Y, Miyazaki T, Tanaka T. In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3). Biomaterials. 2015 52: 14-25 *equally contributed first author

8. Kawabata M, Umemoto N, Shimada Y, Nishimura Y, Zhang B, Kuroyanagi J, Miyabe M, Tanaka T. Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicol Sci. 2015 143: 374-384

9. Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S. Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis. J Nanosci Nanotechnol. 2015 15: 2140-2147.

10. Zhang B, Shimada Y, Kuroyanagi J, Nishimura Y, Umemoto N, Nomoto T, Shintou T, Miyazaki T, Tanaka T. Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors. Tumour Biol. 2014 35: 11861-11869

11. Zang L, Shimada Y, Kawajiria J, Tanaka T, Nishimura N. Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model. J Funct Foods. 2014 10: 499-510.

12. Kuroyanagi J, Shimada Y*, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS Lett. 2014 588: 3409-3016. *equally contributed first author

13. Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T. Zebrafish as a systems toxicology model for developmental neurotoxicity testing. Congenit Anom (Kyoto). 2015 55: 1-16

14. Shimada Y, Nishimura Y, Tanaka T. Zebrafish-based systems pharmacology of cancer metastasis. Methods Mol Biol. 2014 1165: 223-238.

15. Zhang B, Shimada Y, Kuroyanagi J, Umemoto N, Nishimura Y, Tanaka T. Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS One. 2014 9: e85439

16. Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 15: 4: 3708.*equally contributed first author

17. Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Downregulation of max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. Int J Obes. 2013 38: 1053-1060.

18. Umemoto N, Nishimura Y, Shimada Y, Yamanaka Y, Kishi S, Ito S, Okamori K, Nakamura Y, Kuroyanagi J, Zhang Z, Zang L, Wang Z, Nishimura N, Tanaka T. Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging inZebrafish. Mol Biotechnol. 2013 55: 131-142

19. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish. Zebrafish. 2013 10: 425-432

20. Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T.Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models. ACS Chem Neurosci. 2013 4: 1183-1193

21. Shimada Y, Hirano M, Nishimura Y, Tanaka T. A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening. PLoS One. 2012 7: e52549

22. Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T. In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neurosci. 2012 13: 101.

23. Hasumura T, Shimada Y, Kuroyanagi J, Nishimura Y, Meguro S, Takema Y, Tanaka T. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutr Metab. 2012 9: 73.

24. Zang L, Morikane D, Shimada Y, Tanaka T, Nishimura N. A novel protocol for the oral administration of test chemicals to adult zebrafish. Zebrafish. 2011 8: 203-20

25. Tainaka T, Shimada Y*, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T. Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutr Metab. 2011 8: 88 *equally contributed first author

26. Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N and Tanaka T. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity.BMC Physiol. 2010 10: 21

27. Watanabe K, Nishimura Y, Oka T, Nomoto T, Kon T, Shintou T, Hirano M, Shimada Y, Umemoto N, Kuroyanagi J, Wang Z, Zhang Z, Nishimura N, Miyazaki T, Imamura T, Tanaka T. In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neurosci. 2010 11: 116

28. Shimada Y, Tsunoda H, Zang L, Hirano M, Oka T and Tanaka T. Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm. Eur J Pharmacol. 2009 620: 16-20

29. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, Oka T, Sakamoto C, Kuroyanagi J and Tanaka T. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009 446: 18-27

30. Tanaka T, Oka T, Shimada Y, Umemoto N, Kuroyanagi J, Sakamoto C, Zang L, WangZ, Nishimura Y. Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. J Pharmacol Sci. 2008 107: 8-14.

31. Ito Y, Hirano M, Umemoto N, Zang L, Wang Z, Oka T, Shimada Y, Nishimura Y, Kurokawa I, Mizutani H, Tanaka T. Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. BMB Rep. 2008 41: 139-145.

32. Matsumoto T, Komori T, Yamamoto M, Shimada Y, Nakagawa M, Shiroyama T, Inui K, Okazaki Y. Prior intraperitoneal injection of rat recombinant IL-6 increases hypothalamic IL-6 contents in subsequent forced swim stressor in rats. Neuropsychobiology. 2006 54:186-194.

33. Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T. Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. Biochem Biophys Res Commun. 2006 351:185-191.

34. Tanaka T, Oka T, Hirano M, Zang L, Ito Y, Shimada Y. [Genomic drug discovery of vascular remodeling] Nippon Rinsho. 2006 ;64 Suppl 5:576-582. Review.

35. Ogasawara M, Satoh N, Shimada Y, Wang Z, Tanaka T, Noji S. Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses. Dev Genes Evol. 2006 216:100-104.

36. Masunaga R, Nagasaka A, Sawai Y, Hayakawa N, Nakai A, Hotta K, Kato Y, Hishida H, Takahashi H, Naka M, Shimada Y, Tanaka T, Hidaka H, Itoh M.Changes in cyclic nucleotide phosphodiesterase activity and calmodulin concentration in heart muscle of cardiomyopathic hamsters. J Mol Cell Cardiol. 2004 37:767-774.

37. Hayashi M, Shimada Y, Nishimura Y, Hama T, Tanaka T. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem Biophys Res Commun. 2002 297:1253-1258.


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