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三重大学トップページへ

三重大学教員紹介

教員情報

職名
教授
氏名
やまだよしじ
山田 芳司
生年月
1956.06
所属
部局
生命科学研究支援センター
学科・専攻
機能ゲノミクス分野
講座
ヒト機能ゲノミクス部門
教育研究分野
医学系研究科遺伝子病態制御学
TEL
059-231-5387
FAX
059-231-5388
E-mail
yamada@gene. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
学歴
名古屋大学医学部 学士課程 (~1982年)
名古屋大学大学院医学研究科 博士課程・博士後期課程 (~1990年) 卒業・修了
学位
1990.03 医学博士 名古屋大学
所属学会
日本循環器学会 日本内科学会 American Heart Association オミックス医療研究会 国際個別化医療学会
社会活動
医療法人尚豊会 みたき総合病院
医療法人大和会 日下病院
職歴
1982.05~1985.04 医療法人エスエル会SLセントラル病院 医師
1985.05~1986.03 社会保険中京病院循環器科 医師
1990.04~1990.09 国立豊橋病院内科 医師
1990.10~1994.03 米国ユタ州ユタ大学 Research Associate
1994.04~1996.02 国立療養所中部病院循環器科 医師
1996.03~2000.04 国立長寿医療研究センター老年病研究部内科系総合診療研究室 室長
2000.05~2001.03 財団法人岐阜県国際バイオ研究所遺伝子治療研究部 主任研究員
2001.04~2003.03 財団法人岐阜県国際バイオ研究所遺伝子治療研究部 副部長
2003.04~2003.08 財団法人岐阜県国際バイオ研究所遺伝子治療研究部 部長研究員(分子疫学)
2003.09~ 三重大学生命科学研究支援センター 機能ゲノミクス分野ヒト機能ゲノミクス部門長 教授
2003.09~2005.03 三重大学大学院医学系研究科 生命医科学専攻ゲノム細胞医科学講座機能ゲノミクス学 教授(兼担)
2005.04~2012.03 三重大学大学院医学系研究科 生命医科学専攻ゲノム再生医学講座遺伝子病態制御学 教授(兼担)
2005.10~2011.09 クオルセイバー有限責任事業組合 リサーチディレクター(兼任)
2006.04~ 三重大学生命科学研究支援センター 機能ゲノミクス分野長
2008.09~ 三重大学リサーチセンター(疾患ゲノム研究センター) センター長(兼任)
2012.04~ 三重大学大学院医学系研究科 生命医科学専攻基礎医学講座遺伝子病態制御学 教授(兼担)
学術(芸術)賞
Trainee Investigator Award of the AAP/ASCI/AFCR,Trainee Investigator Award
ASBMR-IBMS Travel Award,Travel Award
国立中部病院・長寿医療研究センター優秀研究賞銀賞,優秀研究賞銀賞
第70回記念日本循環器学会総会・学術集会「第31回日本心臓財団 佐藤賞」,第31回日本心臓財団 佐藤賞,日本心臓財団
欧州心臓病学会最優秀ポスター演題賞,欧州心臓病学会最優秀ポスター演題賞,欧州心臓病学会
Award of Exellence in Reviewing ,Award of Excellence in Reviewing ,2016.01
2016 Award of Excellence in Reviewing of Biomedical Reports,2016 Award of Excellence in Reviewing of Biomedical Reports,2016.05
専門分野
ゲノム疫学・機能ゲノム科学
現在の研究課題
2型糖尿病・メタボリックシンドローム・脂質異常症・肥満のゲノム疫学・機能ゲノム科学 循環器疾患(心筋梗塞、冠動脈疾患、高血圧、大動脈瘤、心房細動)のゲノム疫学・機能ゲノム科学 脳血管障害(脳梗塞、脳出血、くも膜下出血)のゲノム疫学・機能ゲノム科学 慢性腎臓病・痛風のゲノム疫学・機能ゲノム科学
担当科目
生命医科学特論 生命科学特論
主な業績等
New diagnostic evidence on the T wave map indicating involved coronary artery in patients with angina pectoris 共著 1988.02 Circulation 77 301-310
Effects of oral elastase on lipid metabolism, platelet function, and blood coagulability in patients with diabetes mellitus 共著 1989.06 Clin Ther 11 786-794
Application of Karhunen-Loeve expansion to evaluate regional cardiac excitation in body surface potential maps 共著 1990.01 J Electrocardiol 23 33-40
Inhibitory effects of endothelial cells and calcium channel blockers on platelet aggregation 共著 1990.02 Jpn Heart J 31 201-215
Roles of calcium, cyclic nucleotides, and protein kinase C in regulation of endothelial permeability 共著 1990.05 Arteriosclerosis 10 410-420
Protective effects of calcium channel blockers on hydrogen peroxideinduced increases in endothelial permeability 共著 1990.12 Cardiovasc Res 24 993-997
Possible mechanism of vascular reocclusion after initially successful thrombolysis with recombinant tissue-type plasminogen activator 共著 1991.06 Am Heart J 121 1618-1627
Adenosine 3':5'-cyclic monophosphate inhibits in vitro angiogenesis induced by endothelial cell growth factor 共著 1992.05 Jpn Heart J 33 373-382
Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction 共著 1992.05 Clin Cardiol 15 358-364
Characterization of the platelet-activating factor acetylhydrolase from human plasma by heterologous expression in Xenopus laevis oocytes 共著 1994.10 Proc Natl Acad Sci USA 91 320-324
Anti-inflammatory properties of a platelet-activating factor acetylhydrolase 共著 1995.04 Nature 374 549-552
Effect of aging on cardiac and electroencephalographic arousal in sleep apnea/hypopnea syndrome 共著 1995.09 J Am Geriatr Soc 43 1070-1071
Platelet-activating factor: a mediator for clinicians 共著 1995.10 J Intern Med 238 5-20
Direct interactions of plasminogen activators with human aortic endothellial cells in vitro: implications for thrombolytic therapy 共著 1996.05 J Cardiovasc Pharmacol 27 629-635
Enhancement of barrier function of human aortic endothelial cells by activators of protein kinase C 共著 1996.05 Biochem Mol Biol Int 39 69-76
The fate of platelet-activating factor: PAF acetylhydrolase from plasma and tissues 共著 1996.06 Advances in Lipobiology 1 141-162
Production of C-type natriuretic peptide from human aortic endothelial cells induced by activation of protein kinase C 共著 1996.09 Am J Hypertens 9 924-929
Effects of protein kinase C activation and inhibition on endothelin-1 release from human aortic and pulmonary artery endothelial cells: comparison with effects on bovine endothelin-1 and human prostaglandin I2 release 共著 1997.01 Am J Hypertens 10 32-42
Association of a deletion polymorphism of the angiotensin-converting enzyme gene with left ventricular hypertrophy in Japanese women with essential hypertension: multicenter study of 1919 subjects 共著 1997.04 Cardiology 88 309-314
Brain natriuretic peptide is a sensitive indicator of impaired left-ventricular function in elderly patients with cardiovascular disease 共著 1997.05 Cardiology 88 401-407
Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281→Arg mutation 共著 1997.07 Biochem Biophys Res Commun 236 772-775
Lack of association between variants of the angiotensinogen gene and coronary artery disease in middle-aged Japanese men 共著 1997.08 Am Heart J 134 260-265
Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy 共著 1997.08 Am J Hypertens 10 921-928
Interaction between nitric oxide synthase and cyclooxygenase pathways in osteoblastic MC3T3-E1 cells 共著 1997.11 J Bone Miner Res 12 1789-1796
Lack of association of angiotensin converting enzyme gene polymorphism or serum enzyme activity with coronary artery disease in Japanese subjects 共著 1997.12 Am J Hypertens 10 1384-1390
Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in Japanese population 共著 1998.01 Am J Cardiol 81 83-86
Identification of the G994→T missense mutation in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men 共著 1998.02 Metabolism 47 177-181
Actions of nitric oxide in the regulation of osteoclasts and osteoblasts 共著 1998.05 Curr Opin Orthop 9 11-16
Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells 共著 1998.05 Biochem Biophys Res Commun 245 419-422
Roles of plasma platelet-activating factor acetylhydrolase in allergic, inflammatory, and atherosclerotic diseases 共著 1998.05 Jpn Circ J 62 328-335
Association of a polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women 共著 1998.10 J Bone Miner Res 13 1569-1576
Transforming growth factor-β stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells 共著 1998.10 J Biol Chem 273 7091-7096
Association of a G994→T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with genetic susceptibility to nonfamilial dilated cardiomyopathy in Japanese 共著 1998.11 Circulation 98 1181-1185
Impaired force-frequency relations in patients with hypertensive left ventricular hypertrophy: a possible physiological marker of the transition from physiologic to pathologic hypertrophy 共著 1999.04 Circulation 99 1822-1830
Immunological characterization of circulating osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis 共著 1999.04 J Bone Miner Res 14 518-527
Transforming growth factor beta-1 gene polymorphism and bone mineral density in Japanese adolescents 共著 1999.04 Am J Med 106 477-479
Familial dilated cardiomyopathy 共著 1999.10 Circulation 100 87-87
Association of transforming growth factor β1 genotype with spinal osteophytosis in Japanese women 共著 2000.02 Arthritis Rheum 43 452-460
Association of transforming growth factor β1 genotype with therapeutic response to active vitamin D for postmenopausal osteoporosis 共著 2000.03 J Bone Miner Res 15 415-420
Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, longitudinal study of aging (NILS-LSA) 共著 2000.04 J Epidemiol 10 46-55
Association of a T29→C polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to myocardial infarction in Japanese 共著 2000.06 Circulation 101 2783-2787
Association of a Leu10Pro polymorphism of the transforming growth factor-β1 with genetic susceptibility to osteoporosis and spinal osteoarthritis 単著 2000.07 Mech Ageing Dev 116 113-123
Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population 共著 2000.07 Atherosclerosis 150 209-216
Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis 共著 2000.07 Mech Ageing Dev 116 65-76
Phenotypic variation of familial hypertrophic cardiomyopathy caused by the Phe110→Ile mutation in cardiac troponin T 共著 2000.07 Cardiology 93 155-162
Prostaglandin E2 induces expression of receptor activator of nuclear factor-κB ligand/osteoprotegerin ligand on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency 共著 2000.07 J Bone Miner Res 15 1321-1329
Association of a polymorphism of the transforming factor beta-1 gene with prevalent vertebral fractures in Japanese women 共著 2000.08 Am J Med 109 244-247
Relation between osteoprotegerin/osteoclestogenesis inhibitory factor concentration in synovial fluid and disease severity in individuals with osteoarthritis of the knee 共著 2001.01 Metabolism 50 1-2
Transforming growth factor-β1 gene polymorphism and bone mineral density 共著 2001.01 JAMA 285 167-168
Antiatherogenic mitochondrial genotype in patients with type 2 diabetes 共著 2001.03 Diabetes Care 24 500-503
Association of a G994→T (Val279→Phe) polymorphism of the plasma platelet-activating factor acetylhydrolase gene with myocardial damage in Japanese patients with nonfamilial hypertrophic cardiomyopathy 共著 2001.05 J Hum Genet 46 436-441
Role of FK506-binding protein 12 in development of the chick embryonic heart 共著 2001.05 Biochem Biophys Res Commun 283 613-620
Association between a polymorphism of the transforming growth factor-b1 gene and genetic susceptibility to ossification of the posterior longitudinal ligament in Japanese patients 共著 2001.06 Spine 26 1264-1266
Association of the C-509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-β1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women 共著 2001.07 J Mol Med 79 149-156
Reduced myocardial sarcoplasmic reticulum Ca2+-ATPase mRNA expression and biphasic force-frequency relation in patients with hypertrophic cardiomyopathy 共著 2001.08 Circulation 104 658-663
Association of polymorphisms of the transforming growth factor-β1 gene with genetic susceptibility to osteoporosis 単著 2001.11 Pharmacogenetics 11 765-771
Mitochondrial ATPase subunit 6 and cytochrome b gene polymorphisms in young obese adults 共著 2002.01 Biochem Biophys Res Commun 290 1199-1205
Association of a polymorphism of the matrix metalloproteinase-1 gene with bone mineral density 共著 2002.05 Matrix Biol 21 389-392
Association of a polymorphism of the transforming growth factor-β1 gene with blood pressure in Japanese individuals 共著 2002.05 J Hum Genet 47 243-248
Association of polymorphisms of the estrogen receptor a gene with bone mineral density of the femoral neck in elderly Japanese women 共著 2002.06 J Mol Med 80 452-460
Effects of FK506 and rapamycin on formation of the neural tube in chick embryos 共著 2002.06 Anim Sci J 73 229-234
Association of a polymorphism of the CC chemokine receptor-2 gene with bone mineral density 共著 2002.07 Genomics 80 8-12
Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson’s disease 共著 2002.07 J Neurosci Res 70 347-355
Reduction in the extent of atherosclerosis in apolipoprotein E-deficient mice induced by electroporation-mediated transfer of the human plasma platelet-activating factor acetylhydrolase gene into skeletal muscle 共著 2002.07 Prostaglandins Other Lipid Mediat 70 107-118
AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats 共著 2002.08 Hypertension 40 168-174
Gene therapy for mitochondrial disease by delivering restriction endonusclease SmaI into mitchondria 共著 2002.09 J Biomed Sci 9 534-541
A mitochondrial genotype associated with the development of autoimmune-related type 1 diabetes 共著 2002.11 Diabetes Care 25 2106-2106
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes 共著 2002.12 N Engl J Med 347 1916-1923
Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer 共著 2003.01 J Mol Med 81 126-131
Molecular genetics and epidemiology of osteoporosis 単著 2003.01 Curr Pharmacogenomics 1 139-149
Risk of Myocardial infarction and polymorphisms in candidate genes 共著 2003.03 N Engl J Med 348 1176-1177
Human plasma platelet-activating factor acetylhydrolase binds to all the murine lipoproteins, conferring protection against oxidative stress 共著 2003.05 Arterioscler Thromb Vasc Biol 23 829-835
Prediction of genetic risk for hypertension 共著 2003.05 Hypertension 41 1035-1040
Association of polymorphisms in the interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men 共著 2003.07 J Clin Endocrinol Metab 88 3372-3378
Association of polymorphisms of paraoxonase 1 and 2 genes, alone or in combination, with bone mineral density in community-dwelling Japanese 共著 2003.07 J Hum Genet 48 469-475
Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors 共著 2003.10 J Am Coll Cardiol 42 1429-1437
Association of a polymorphism of the dopamine receptor D4 gene with bone mineral density in Japanese men 共著 2003.11 J Hum Genet 48 629-633
Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men 共著 2003.11 Mol Genet Metab 80 344-349
Association of gene polymorphisms with coronary artery disease. 共著 2004 J Am Coll Cardiol 44 209-210
Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia 共著 2004.01 Atherosclerosis 172 167-173
Genetic risk and gene-environmental interaction in coronary artery spasm in Japanese men and women 共著 2004.01 Eur Heart J 25 970-977
Association of a polymorphism of the matrix metalloproteinase-9 gene with bone mineral density in Japanese men 共著 2004.02 Metabolism 53 135-137
Genetic risk for coronary artery disease in individuals with or without type 2 diabetes 共著 2004.04 Mol Genet Metab 81 282-290
Genetic risk for restenosis after coronary balloon angioplasty 共著 2004.05 Atherosclerosis 174 181-187
Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese 共著 2004.07 J Mol Med 82 477-483
Association of a 5178C→A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals 共著 2004.08 Atherosclerosis 175 281-286
Mitochondrial Genome Variation in Eastern Asia and the peopling of Japan 共著 2004.10 Genome Res 14 1832-1850
Book review: Genetic Disorders of the Indian Subcontinent. 単著 2005 J Med Genet 43 288-
Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women 共著 2005.01 J Mol Med 83 50-57
Association of a -1997G→T polymorphism of collagen Iα1 gene with bone mineral density 共著 2005.02 Hum Biol 77 27-36
Association of polymorphisms in CYP17, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men 共著 2005.07 Genomics 86 76-85
Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway 共著 2005.12 Biochem Biophys Res Commun 338 1299-1305
Identification of genetic factors and development of genetic risk diagnosis systems for cardiovascular diseases and stroke. 単著 2006 Circ J 70 1240-1248
Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women 共著 2006.01 Int J Mol Med 17 83-88
Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure 共著 2006.02 Cardiovasc Res 69 726-735
Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals 共著 2006.07 Int J Mol Med 18 119-127
Assessment of genetic risk for myocardial infarction 共著 2006.08 Thromb Haemost 96 220-227
Assessment of the genetic factors for type 2 diabetes mellitus 共著 2006.08 Int J Mol Med 18 299-308
Attenuation of cardiac dysfunction by a PPAR-α agonist is associated with down-regulation of redox-regulated transcription factors 共著 2006.08 J Mol Cell Cardiol 41 318-329
Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation 共著 2006.08 Arch Med Res 37 696-699
Genetic risk for ischemic and hemorrhagic stroke 共著 2006.08 Arterioscler Thromb Vasc Biol
Role of the second-largest subunit of DNA polymerase α in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase 共著 2006.09 Biochim Biophys Acta – Proteins and Proteomics 1764 1447-1453
Assessment of genetic component for hypertension 共著 2006.11 Am J Hypertens 19 1158-1165
Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal mode of dilated cardiomyopathy 共著 2006.11 Biochem Biophys Res Commun 350 105-113
Genetic factors for obesity 共著 2006.11 Int J Mol Med 18 843-851
Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis 共著 2006.11 Int J Mol Med 18 871-883
A role of aryl hydrocardon receptor in the regulation of angiogenesis. 共著 2007 Arterioscler Thromb Vasc Biol 27 1297-1304
Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus. 共著 2007 Int J Mol Med 20 703-707
Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men. 共著 2007 Int J Mol Med 19 791-801
Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals. 共著 2007 Int J Mol Med 19 675-683
Association of gene polymorphisms with myocardial infarction in individuals with different lipid profiles. 共著 2007 Int J Mol Med 20 581-590
Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors. 共著 2007 Int J Mol Med 19 129-141
Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus. 共著 2007 Int J Mol Med 19 631-637
Genetic factors for lone atrial fibrillation. 共著 2007 Int J Mol Med 19 933-939
Genetic risk for restenosis after coronary stenting. 共著 2007 Atherosclerosis 194 172-178
Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries. 共著 2007 Int J Mol Med 20 533-538
Mitochondrial haplogroup A is a genetic risk factor for atherothrombotic cerebral infarction in Japanese females. 共著 2007 Mitochondrion 7 72-79
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. 共著 2007 Am J Hum Genet 80 407-415
Mitochondrial haplogroup N9b is protective against myocardial infarction in Japanese males. 共著 2007 Hum Genet 120 827-836
PIASy controls ubiquitination-dependent proteosomal degradation of Ets-1. 単著 2007 Biochem J 405 481-488
Prediction of genetic risk for dyslipidemia. 共著 2007 Genomics 90 551-558
Prediction of genetic risk for metabolic syndrome. 共著 2007 Atherosclerosis 191 298-304
Repression of E1AF transcriptional activity by sumoylation and PIASy. 共著 2007 Biochem Biophys Res Commun 360 226-232
Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity. 共著 2007 Biochem Biophys Res Commun 359 27-33
Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensives and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias. 共著 2007 J Hypertens 25 1763-1774
Women with mitochondrial haplogroup N9a are protected against metabolic syndrome. 共著 2007 Diabetes 56 518-521
Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors 共著 2007.01 Int J Mol Med 19 129-141
Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients. 共著 2008 Am J Hypertens 21 1023-1027
Association of a polymorphism of ABCB1 with obesity in Japanese individuals. 共著 2008 Genomics 91 512-516
Association of candidate gene polymorphisms with atherothrombotic cerebral infarction among Japanese indivuduals with metabolic syndrome. 共著 2008 Int J Mol Med 21 801-808
Association of genetic variants of APOA5 and PRKCH with hypertension in community-dwelling Japanese individuals. 共著 2008 Mol Med Rep 1 407-414
Association of genetic variants of MAOA and SH2B1 with bone mineral density in community-dwelling Japanese women. 共著 2008 Mol Med Rep 1 269-274
Association of genetic variants with atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome. 共著 2008 Int J Mol Med 21 801-808
Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals. 共著 2008 Int J Mol Med 21 83-89
Editorial commentary: The electronic health recored as a primary source of clinical phenotype for genetic epidemiological studies. 単著 2008 Genomic Med 2 5-5
Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals. 共著 2008 Stroke
Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals. 共著 2008 Stroke 39 2211-2218
Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese individuals. 共著 2008 J Med Genet 45 22-28
Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in Japanese individuals. 共著 2008 J Med Genet 45 216-221
Genetics factors for human obesity. 共著 2008 Cell Mol Life Sci 65 1086-1098
Hyper-phosphorylated retinoblastoma protein suppresses telomere elongation. 共著 2008 Biosci Biotech Biochem 72 630-635
Meta-analysis of the association of four angiotensinogen polymorphisms with essential hypertension: a role beyond M235T? 共著 2008 Hypertension 51 778-783
Molecular genetics of myocardial infarction. 共著 2008 Genomic Med 2 7-22
Proinflammatory gene polymorphisms and ischemic stroke. 共著 2008 Curr Pharm Des 14 3590-3600
SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin. 共著 2008 Biochem Biophys Res Commun 374 382-387
Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease. 共著 2009 Mol Med Rep 2 779-785
Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease. 共著 2009 Mol Med Rep 2 205-211
Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor. 共著 2009 Biochem Biophys Res Commun 381 44-49
Genome-wide association studies of myocardial infarction. 単著 2009.01 International Atherosclerosis Society (http://www.athero/org/) published online
Association of a polymorphism of apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. 共著 2009.03 Genomics 93 221-226
Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. 共著 2009.04 Int J Mol Med 23 529-537
Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension. 共著 2009.05 Hypertens Res 32 411-418
Association of genetic variants with chronic kidney disease in Japanese individuals. 共著 2009.05 Clin J Am Soc Nephrol 4 883-890
Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease. 共著 2009.05 Thromb Haemost 101 963-968
Association of genetic variants with myocardial infarction in Japanese individuals with metabolic syndrome. 共著 2009.05 Atherosclerosis
Association of polymorphisms of SORBS1, GCK, and WISP1 with hypertension in community-dwelling Japanese individuals. 共著 2009.05 Hypertens Res 32 325-331
Association of gene polymorphisms with chronic kidney disease in high-risk or low-risk subjects defined by conventional risk factors. 共著 2009.06 Int J Mol Med 23 785-792
Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. 共著 2009.08 Int J Mol Med 24 233-246
Association of gene polymorphisms with chronic kidney disease in Japanese individuals. 共著 2009.10 Int J Mol Med 24 539-547
Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease. 共著 2009.10 Hum Genet 126 539-547
Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus. 単著 2009.11 Int J Mol Med 24 701-709
Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. 共著 2009.11 Atherosclerosis
Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response. 共著 2010 Arterioscler Thromb Vasc Biol 30 1553-1561
Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease. 共著 2010 Exp Ther Med 1 377-384
Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals. 共著 2010 Atherosclerosis 210 468-473
Association of genetic variants with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus. 共著 2010 Exp Ther Med 1 137-145
Association of genetic variants with myocardial infarction in Japanese individuals with or without metabolic syndrome. 共著 2010 Exp Ther Med 1 969-975
Genetic risk for myocardial infarction in Japanese individuals with or without chronic kidney disease. 共著 2010 Int J Mol Med 25 743-749
Triglyceride-mediated pathways and coronary disease: collaborative analysis for 101 studies. 共著 2010 Lancet 375 1634-1639
Assessment of a polymorphism of SDK1 with hypertension in Japanese individuals. 共著 2010.01 Am J Hypertens 23 70-77
Association of genetic variants with ischemic stroke in Japanese individuals with or without metabolic syndrome. 共著 2010.02 Int J Mol Med 25 281-286
Association of genetic variants with hemorrhagic stroke in Japanese individuals. 共著 2010.03 Int J Mol Med 25 649-656
Association of genetic variants with myocardial infarction in Japanese individuals with different lipif profiles. 共著 2010.03 Int J Mol Med 25 607-616
ADRB2 and LEPR gene polymorphisms: synergistic effects on the risk of obesity in Japanese. 共著 2011 Obesity 19 1523-1527
Association of a genetic variant of BTN2A1 with chronic kidney disease in Japanese individuals 共著 2011 Nephrology 16 642-648
Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations. 共著 2011 J Med Genet 48 787-792
Association of a polymorphism of BTN2A1 with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus. 共著 2011 Exp Ther Med 2 325-331
Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations. 共著 2011 Exp Ther Med 2 745-749
Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals. 共著 2011 Am J Hypertens 24 924-929
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. 共著 2011 Atherosclerosis 215 145-152
Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals. 共著 2011 Diabetic Med 28 1381-1387
Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles. 共著 2011 Mol Med Rep 4 511-518
Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus, or chronic kidney disease. 共著 2011 Int J Mol Med 27 745-752
The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation. 共著 2011 Biochem Biophys Res Commun 406 285-291
Association of a genetic variant of BTN2A1 with chronic kidney disease in Japanese individuals. 単著 2011.06 Hemodialysis.com (http://www.hemodialysis.com/)
Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat. 共著 2012 Nutr Metab 9 87-
Association of a matrix metallopeptidase gene (MMP1) polymorphism with long-term outcome of thoracic aortic aneurysm. 共著 2012 Int J Mol Med 29 125-132
Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. 共著 2012 PLoS Med 9 1001177-
Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome in East Asian populations. 共著 2012 Int J Mol Med 30 185-192
Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals. 共著 2013 Biomed Rep 1 868-872
Association of genetic variants of CELSR1 and 3q28 with hypertension in community-dwelling individuals. 共著 2013 Biomed Rep 1 840-844
Identification of 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study. 共著 2013 J Med Genet 50 410-418
Rats with metabolic syndrome resist the protective effects of N-acetyll-cystein against impaired spermatogenesis induced by high-phosphorus/zinc-free diet. 共著 2013 Exp Toxicol Pathol 65 1173-1182
Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome 共著 2013 Clin Exp Pharmacol Physiol 40 443-448
Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community-dwelling individuals. 共著 2014 Biomed Rep 1 940-944
Association of a butyrophilin, subfamily 2, member A1 gene polymorphism with hypertension. 共著 2014 Biomed Rep 2 818-822
Association of a polymorphism of BTN2A1 with dislipidemia in community-dwelling individuals. 共著 2014 Mol Med Rep 9 808-812
Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals. 共著 2014 Mol Med Rep 9 808-812
Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals. 共著 2014 Biomed Rep 2 127-131
Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals. 共著 2014 Biomed Rep 2 127-131
Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat. 共著 2014 Diabetol Metab Syndr 6 8-8
Identification of hypo- and hypermethylated genes related to atherosclerosis by a genome-wide analysis of DNA methylation. 共著 2014 Int Mol Med 33 1355-1363
Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes. 共著 2014 Mol Biol Rep 41 3113-3125
Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. 共著 2014 J Clin Invest 124 5159-5174
Age-related changes in clinical parameters and their relations to common complex diseases. 共著 2015 Biomed Rep 3 767-777
Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus. 共著 2015 Biomed Rep 3 88-92
Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals. 共著 2015 Nephrology 20 273-278
Association of a transcription factor 21 gene polymorphism with hypertension. 共著 2015 Biomed Rep 3 118-122
Association of genetic variants of the alpha-kinase 1 gene with type 2 diabetes mellitus in a longitudinal population-based genetic epidemiological study. 共著 2015 Biomed Rep 3 347-354
Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study. 共著 2015 Biomed Rep 3 413-419
Association of genetic variants with dyslipidemia and chronic kidney disease in a longitudinal population-based genetic epidemiological study. 共著 2015 Int Mol Med 35 1290-1300
Association of genetic variants with dyslipidemia. 共著 2015 Mol Med Rep 12 5429-5436
Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. 共著 2015 Int J Mol Med 35 1189-1198
Association of polymorphisms of FURIN and ZPR1 with metabolic syndrome. 共著 2015 Biomed Rep 3 641-647
Association of polymorphisms of TOMM40 and SLC22A4 with ischemic stroke. 共著 2015 Biomed Rep 3 491-498
Association of six genetic variants with myocardial infarction. 共著 2015 Int J Mol Med 35 1451-1459
Association of the chromodomain helicase DNA-binding protein 4 (CHD4) missense variation p.D140E with cancer: potential interaction with smoking. 共著 2015 Genes Chromosomes Cancer 54 122-128
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. 共著 2015 Mol Brain 8 50-50
Genetic risk score based on the lifetime prevalence of femoral fracture in 1632 consecutive Japanese autopsy cases. 共著 2015 J Bone Miner Metab (published online)
Molecular genetics of coronary artery disease and ischemic stroke. 単著 2015 Personalized Medicine Universe 4 4-12
Privacy-preserving genome-wide association studies on cloud environment using fully homomorphic encryption. 共著 2015 BMC Med Inform Decis Mak 15 S1-
Strategic aspects of higher education reform to cultivate specialists in diagnostic and biopharma industry as applicable to Predictive, Preventive and Personalized Medicine as the Medicine of the Future. 共著 2015 EPMA J 6 18-18
Zn(II) released from zinc oxide nano/micro particles suppresses vasculogenesis in human endothelial colony-forming cells. 共著 2015 Toxicol Rep 2 692-701
Efficient secure outsourcing of genome-wide association studies. 共著 2015.05 Proceedings of IEEE Security and Privacy Workshop 3-6
Privacy-preserving statistical analysis by exact logistic regression. 共著 2015.05 Proceedings of IEEE Security and Privacy Workshop 7-16
A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with the risk of osteoporosis and femoral fracture in the Japanese population. 共著 2015.11 J Bone Miner Metab 33 694-700
Association of genetic variants with atrial fibrillation. 共著 2016 Biomed Rep 4 178-182
Exome-wide association study identifies CLEC3B missense variant p.S106G as being associated with extreme longevity in East Asian populations. 共著 2016 J Gerontol A Biol Sci Med Sci
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. 共著 2016 Neurology 86 146-153
SUMOylation of the KRAB zinc-finger transcription factor PARIS/ZNF746 regulates its transcriptional activity. 共著 2016.04 Biochem Bioiphys Res Commun
Titanium dioxide particle type and concentration influence the inflammatory response in a model of human intestinal tract. 共著 2016.04 Int J Mol Sci
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Clinical Cardiovascular Genetics: Principle and Practice. 共著 2010 New York:Oxford University Press
Clinical Cardiovascular Genetics: Principle and Practice. 共著 2010 Oxford University Press
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Coronary stent restenosis. 2011 Bucharest:The Publishing House of the Romanian Academy
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Genomic and Molecular Medicine. 2012.04 Princeton: Morgan & Claypool Life Sciences
Genomic Medicine: Principle and Practice 単著or編著 2015 New York: Oxford University Press


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