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三重大学教員紹介

教員情報

職名
講師
氏名
ひらくゆうすけ
平工 雄介
生年月
1969.02
所属
部局
医学系研究科
学科・専攻
生命医科学専攻
講座
基礎医学系講座
教育研究分野
環境分子医学
TEL
059-231-5011
FAX
059-231-5011
E-mail
y-hiraku@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
学歴
1994 京都大学医学部医学科 卒業
1998 京都大学大学院医学研究科(社会医学系) 修了
学位
1998 京都大学 博士(医学)
所属学会
日本衛生学会(評議員)、日本産業衛生学会(代議員、東海地方会理事)、日本公衆衛生学会、東海公衆衛生学会、三重県公衆衛生協会(幹事)、日本癌学会、日本生化学会、日本酸化ストレス学会、日本NO学会、日本光医学・光生物学会、日本環境変異原学会、日本DOHaD研究会(幹事)、国際DOHaD学会、環境ホルモン学会(日本内分泌撹乱化学物質学会)、The New York Academy of Sciences
社会活動
2011~2017 日本産業衛生学会 編集委員 (2011~2014 副編集委員長)
2015~ 三重県公害審査会委員
職歴
2000.04~2005.03 三重大学医学部 助手
2005.04~2006.01 三重大学大学院医学系研究科 助手
2006.02~ 三重大学大学院医学系研究科 講師
2013.04~ 三重大学大学院医学系研究科 研究教授
2014.04~ 三重大学付属病院疫学センター 副センター長 (兼任)
学術(芸術)賞
2008 三重大学医学部新研究プロジェクト Young Investigator Award
2009 日本衛生学会 奨励賞
2011 日本産業衛生学会 優秀演題
専門分野
衛生学 環境医学 分子予防医学
現在の研究課題
環境発がん物質によるDNA損傷機構の解明
感染・炎症関連発がんの分子機構の解明
繊維・粒子状物質による健康障害の分子機構の解明とリスク評価法の開発
担当科目
(学部) 社会と医学 衛生学実習 医学文献抄読
(大学院) 環境生命科学
主な業績等
Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M. Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation. Part Fibre Toxicol 13: 16 (2016)
Hiraku Y, Sakai K, Shibata E, Kamijima M, Hisanaga N, Ma N, Kawanishi S, Murata M. Formation of the nitrative DNA lesion 8-nitroguanine is associated with asbestos contents in human lung tissues: a pilot study. J Occup Health 56: 186-196 (2014)
Hiraku Y, Goto H, Kohno M, Kawanishi S, Murata M. Metal-mediated oxidative DNA damage induced by methylene blue. Biochim Biophys Acta 1840: 2776-2782 (2014)
Hiraku Y, Kawanishi S. Role of nitrative DNA damage in inflammation-related carcinogenesis. In: Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects. Hiraku Y, Kawanishi S, Ohshima H (ed.). Wiley, 41-59 (2014)
Hiraku Y. Role of chronic inflammation and resulting DNA damage in cervical carcinogenesis induced by human papillomavirus. In: Human Papillomavirus and Related Diseases - From Bench to Bedside - Research aspects. Broeck DV (ed.). InTech, 359-382 (2012)
Guo F, Ma N, Horibe Y, Kawanishi S, Murata M, Hiraku Y. Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells. Toxicol Appl Pharmacol 260: 183-192 (2012)
Prakobwong S, Khoontawad J, Yongvanit P, Pairojkul C, Hiraku Y, Sithithaworn P, Pinlaor P, Aggarwal BB, Pinlaor S. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. Int J Cancer 129: 88-100 (2011)
Hiraku Y, Kawanishi S, Ichinose T, Murata M. The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis. Ann NY Acad Sci 1203: 15-22 (2010)
Hiraku Y. Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance. Environ Health Prev Med 15: 63-72 (2010)
Prakobwong S, Yongvanit P, Hiraku Y, Pairojkul C, Sithithaworn P, Pinlaor P, Pinlaor S. Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model. Int J Cancer 127: 2576-2587 (2010)
Mizutani H, Hiraku Y, Tada-Oikawa S, Murata M, Ikemura K, Iwamoto T, Kagawa Y, Okuda M, Kawanishi S. Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide. Cancer Sci 101: 2214-2219 (2010)
Hiraku Y, Kawanishi S. Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis. In: Nitric Oxide and Cancer: Prognosis, Prevention and Therapy. Bonavida B (ed.). Springer, 341-360 (2010)
Hiraku Y, Kawanishi S. Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis. In: Methods in Molecular Biology, vol 512. Walker J (ed.). Springer, 3-13 (2009)
Thanan R, Murata M, Pinlaor S, Sithithaworn P, Khuntikeo N, Tangkanakul W, Hiraku Y, Oikawa S, Yongvanit P, Kawanishi S. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis. Cancer Epidemiol Biomarkers Prev 17: 518-524 (2008)
Ma N, Kawanishi M, Hiraku Y, Murata M, Huang GW, Huang Y, Luo DZ, Mo WG, Fukui Y, Kawanishi S. Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: The relation to STAT3 activation and EGFR expression. Int J Cancer 122: 2517-2525 (2008)
Hiraku Y, Ito K, Hirakawa K, Kawanishi S. Photosensitized DNA damage and its protection via a novel mechanism. Photochem Photobiol 83: 205-212 (2007)
Hiraku Y, Tabata T, Ma N, Murata M, Ding X, Kawanishi S. Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection. Cancer Sci 98: 964-972 (2007)
Hoki Y, Hiraku Y, Ma N, Murata M, Matsumine A, Nagahama M, Shintani K, Uchida A, Kawanishi S. iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis. Cancer Sci 98: 163-168 (2007)
Pinlaor S, Hiraku Y, Yongvanit P, Tada-Oikawa S, Ma N, Pinlaor P, Sithithaworn P, Sripa B, Murata M, Oikawa S, Kawanishi S. iNOS-dependent DNA damage via NF-κB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel. Int J Cancer 119: 1067-1072 (2006)
Kawanishi S, Hiraku Y, Pinlaor S, Ma N. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem 387: 365-372 (2006)
Kawanishi S, Hiraku Y. Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation. Antioxid Redox Signal 8: 1047-1058 (2006)
Hiraku Y, Murata M, Kawanishi S. Role of oxidative DNA damage in dietary carcinogenesis. Genes Environ 28: 127-140 (2006)
Pinlaor S, Sripa B, Ma N, Hiraku Y, Yongvanit P, Wongkham S, Pairojkul C, Bhudhisawasdi V, Oikawa S, Murata M, Semba R, Kawanishi S. Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. World J Gastroenterol 11: 4644-4649 (2005)
Iwamoto T, Hiraku Y, Kojima M, Kawanishi S. Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines. Arch Biochem Biophys 434: 232-240 (2005)
Horiike S, Kawanishi S, Kaito M, Ma N, Tanaka H, Fujita N, Iwasa M, Kobayashi Y, Hiraku Y, Oikawa S, Murata M, Wang J, Semba R, Watanabe S, Adachi Y. Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C. J Hepatol 43: 403-410 (2005)
Ding X, Hiraku Y, Ma N, Kato T, Saito K, Nagahama M, Semba R, Kuribayashi K, Kawanishi S. Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease. Cancer Sci 96: 157-163 (2005)
Hiraku Y, Sekine A, Nabeshi H, Midorikawa K, Murata M, Kumagai Y, Kawanishi S. Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation. Cancer Lett 215: 141-150 (2004)
Pinlaor S, Ma N, Hiraku Y, Yongvanit P, Semba R, Oikawa S, Murata M, Sripa B, Sithithaworn P, Kawanishi S. Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase. Carcinogenesis 25: 1535-1542 (2004)
Pinlaor S, Hiraku Y, Ma N, Yongvanit P, Semba R, Oikawa S, Murata M, Sripa B, Sithithaworn P, Kawanishi S. Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis. Nitric Oxide 11: 175-183 (2004)
Ma N, Adachi Y, Hiraku Y, Horiki N, Horiike S, Imoto I, Pinlaor S, Murata M, Semba R, Kawanishi S. Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection. Biochem Biophys Res Commun 319: 506-510 (2004)
Hiraku Y, Murata M, Kawanishi S. Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay. Biochim Biophys Acta 1570: 47-52 (2002)
Hiraku Y, Yamashita N, Nishiguchi M, Kawanishi S. Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation. Int J Cancer 92: 333-337 (2001)
Hiraku Y, Kawanishi S. Distinct mechanisms of guanine-specific DNA photodamage induced by nalidixic acid and fluoroquinolone antibacterials. Arch Biochem Biophys 382: 211-218 (2000)
Hiraku Y, Sugimoto J, Yamaguchi T, Kawanishi S. Oxidative DNA damage induced by aminoacetone, an amino acid metabolite. Arch Biochem Biophys 365: 62-70 (1999)
Hiraku Y, Yamasaki M, Kawanishi S. Oxidative DNA damage induced by homogentisic acid, a tyrosine metabolite. FEBS Lett 432: 13-16 (1998)
Hiraku Y, Ito H, Kawanishi S. Site-specific hydroxylation at polyguanosine in double-stranded DNA by UVA radiation with nalidixic acid. Biochem Biophys Res Commun 251: 466-470 (1998)
Hiraku Y, Kawanishi S. Mechanism of oxidative DNA damage induced by δ-aminolevulinic acid in the presence of copper ion. Cancer Res 56: 1786-1793 (1996)
Hiraku Y, Kawanishi S. Oxidative DNA damage and apoptosis induced by benzene metabolites. Cancer Res 56: 5172-5178 (1996)
Hiraku Y, Inoue S, Oikawa S, Yamamoto K, Tada S, Nishino K, Kawanishi S. Metal-mediated oxidative damage to cellular and isolated DNA by certain tryptophan metabolites. Carcinogenesis 16: 349-356 (1995)


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