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三重大学教員紹介

教員情報

職名
教授
氏名
むらたまりこ
村田真理子
生年月
1958.09
所属
部局
医学系研究科
学科・専攻
生命医科学専攻
講座
基礎医学系講座
教育研究分野
環境分子医学
TEL
059-231-5011
FAX
059-231-5011
E-mail
mmurata@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
 
学歴
三重大学医学部 学士課程 (~1984年)

学位
1989.12 医学博士 三重大学
所属学会
日本衛生学会 日本産業衛生学会 日本公衆衛生学会 日本癌学会
社会活動
三重労働局(労災医員)
三重産業保健推進センター(相談員)
三重労働基準協会連合会(技能講習等講師)



職歴
 
学術(芸術)賞
 
専門分野
環境衛生学
現在の研究課題
環境因子による発がん機構の解明に関する研究
担当科目
F生命医科学の現代的課題 環境生命科学
社会と医学(衛生学)
主な業績等
Murata M, Kawanishi S. (2011) Mechanisms of oxidative DNA damage induced by carcinogenic arylamines. Front Biosci. 16, 1132-43.

Shumin Wang, Xue Xiao, Xiaoying Zhou, Tingting Huang, Chunping Du, Nana Yu, Yingxi Mo, Longde Lin, Jinyan Zhang, Ning Ma, Mariko Murata, Guangwu Huang and Zhe Zhang (2010) TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma. BMC Cancer 10, 617.

Watanabe C., Egami T., Midorikawa K., Hiraku Y., Oikawa S., Kawanishi S., Murata M. (2010) DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite. Environ. Health Prev. Med.15, 319-326.

Furukawa A, Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A, Kawanishi S. (2010) Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole. Mutat Res. 694(1-2):7-12.

Beppu T, Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Matsuda Y, Toda M, Miyake Y, Shiraki K, Murata M, Murata T, Yano Y, Morser J, Gabazza EC, Takei Y. (2010) High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double deficient mice. J Thromb Haemost. 8(11):2514-22.

Mizutani H, Hiraku Y, Tada-Oikawa S, Murata M, Ikemura K, Iwamoto T, Kagawa Y, Okuda M, Kawanishi S. (2010) Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide. Cancer Sci., 101, 2214-9.

Huang Y-J., Zhang B-B., Ma N., Murata M., Tang A-z., Huang G-W. (2010) Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma. Med Oncol. 28(1):377-84.

Hiraku Y., Kawanishi S., Ichinose T., Murata M. (2010) The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis, Ann. NY Acad. Sci. 1203, 15-22.

Minata M, Harada KH, Karrman A, Hitomi T, Hirosawa M, Murata M, Gonzalez FJ, Koizumi A. (2010) Role of Peroxisome Proliferator-activated Receptor-alpha in Hepatobiliary Injury Induced by Ammonium Perfluorooctanoate in Mouse Liver. Ind. Health 48, 96-107.

Kobayashi H, Fukuhara K, Tada-Oikawa S, Yada Y, Hiraku Y, Murata M, Oikawa S. (2009) The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease. J Neurochem 108, 397-407.

Oikawa S, Yamada T, Minohata T, Kobayashi H, Furukawa A, Tada-Oikawa S, Hiraku Y, Murata M, Kikuchi M, Yamashima T. (2009) Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion. Free Radic Biol Med. 46, 1472-1477.

Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis. Cancer Epidemiol Biomarkers Prev. 2008 17(3):518-24.

Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression. Int J Cancer. 2008 122(11):2517-25.

Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis. Biochem Pharmacol. 2008 75(2):552-61.

8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer. Oncol Rep. 2007 18(5):1165-9.

iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis. Cancer Science 2007 98 2 163-8

Nitrative and oxidative DNA damage in cervical ntraepithelial neoplasia associated with human papilloma virus infection. Cancer Sci. 2007 98(7):964-72.

Tyrosine-dependent oxidative DNA damage induced by carcinogenic tetranitromethane. Chem Res Toxicol. 2006 19(10):1379-85.


8-Nitroguanine formation in oral leukoplakia, a premalignant lesion. Nitric oxide 2006 14 2 137-43

Carcinogenic 3-nitrobenzanthrone induces oxidative damage to isolated and cellular DNA. Free radical biology & medicine 2006 40 7 1242-9

Mechanism of DNA damage induced by bromate differs from general types of oxidative stress. Toxicology 2006 221 2-3 172-8

iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel. International Journal of Cancer. 2006 119 5 1067-72

Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase. Mutation research 2006 607 2 184-91

Histone peptide AKRHRK enhances H(2)O(2)-induced DNA damage and alters its site specificity. Biochemical and biophysical research communications 2005 333 4 1073-7

Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. World journal of gastroenterology 2005 11 30 4644-9.

Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C. Journal of hepatology. 2005 43 3 403-10

Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis. Cancer science 2005 96 9 553-9

Oxidative DNA damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmentally relevant levels. Journal of occupational health 2005 47 5 445-9

Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. Free radical biology & medicine. 2005 39 8 1041-9

Evaluation for safety of antioxidant chemopreventive agents. Antioxidants & redox signaling 2005 7 11-12 1728-39


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