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三重大学教員紹介

教員情報

職名
准教授
氏名
つるどめまさと
鶴留 雅人
生年月
1955.12
所属
部局
医学系研究科
学科・専攻
生命医科学専攻
講座
基礎医学系講座
教育研究分野
 
TEL
059-231-5413
FAX
059-231-5413
E-mail
turudome@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
 
学歴
東京大学農学部 学士課程 (~1979年)
東京大学大学院農学系研究科 修士課程・博士前期課程 (~) 中退
学位
1988.02 農学博士 東京大学
2008.12 医学博士 三重大学
所属学会
日本ウイルス学会 日本獣医学会 American Society for Microbiology
社会活動
三重看護専門学校
四日市医師会看護専門学校
職歴
1986.04~1989.05 三重大学 文部教官 助手
1989.06~1991.03 三重大学 文部教官 講師
1991.04~2004.03 三重大学 文部教官 助教授
2004.04~2005.03 国立大学法人 三重大学 教員 助教授
2007.04~ 国立大学法人 三重大学 教員 准教授
学術(芸術)賞
 
専門分野
ウイルス学 
分子生物学
現在の研究課題
ウイルスの病原性を規定する因子に関する研究 ウイルス糖蛋白による膜融合のメカニズムの解明
担当科目
生体防御の分子基盤
主な業績等
Replication of mumps virus in murine cells. 共著 1984.01 Archives of Virology 81 13-24
Monoclonal antibodies against the glycoproteins of mumps virus.:Fusion inhibition by anti-HN monoclonal antibody. 共著 1986.10 Journal of General Virology 67 2259-2265
Replication of mumps virus in mouse.:Transient replication in lung and potential of systemic infection. 共著 1987.03 Archives of Virology 97 167-179
ヒト病原ウイルスの感染防御抗原:ムンプスウイルス 共著 1987.10 日本臨牀 45 74-78
Extensive antigenic diversity among human parainfluenza type 2 virus isolates and immunological relationships among paramyxoviruses revealed by monoclonal antibodies. 共著 1989.07 Virology 171 38-48
Monoclonal antibodies against the nucleoprotein of mumps virus.:their binding characteristics and cross-reactivity with other paramyxoviruses. 共著 1990.05 Acta Virologica 34 220-227
Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus. 共著 1990.12 Virology 179 738-748
Molecular relationships between human parainfluenza virus type 2, and simian viruses 41 and 5.:Determination of nucleoprotein gene sequences of simian viruses 41 and 5. 共著 1991.09 Journal of General Virology 72 2289-2292
Transcripts of simian virus 41 (SV41) matrix gene are exclusively dicistronic with the fusion gene which is also transcribed as a monocistron. 共著 1991.09 Virology 184 93-100
Lipid interactions of the hemagglutinin HA2 NH2-terminal segment during influenza virus-induced membrane fusion. 共著 1992.10 Journal of Biological Chemistry 567 20225-20232
A cell fusion-inhibiting monoclonal antibody binds to the presumed stalk domain of the human parainfluenza type 2 virus hemagglutinin-neuraminidase protein. 共著 1995.02 Virology 206 1117-1125
Identification of regions on the hemagglutinin-neuraminidase protein of human parainfluenza virus type 2 important for promoting cell fusion. 共著 1995.10 Virology 213 190-203
Role of a single amino acid at the amino terminus of the simian virus 5 F2 subunit in syncytium formation. 共著 1997.12 Journal of Virology 71 9855-9858
Identification of regions on the fusion protein of human parainfluenza virus type 2 which are required for haemagglutinin-neuraminidase proteins to promote cell fusion. 共著 1998.02 Journal of General Virology 79 279-289
Cutting edge: primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16. 共著 1999.05 Journal of Immunology 162 2462-2466
細胞融合誘導に関わるパラミクソウイルス糖タンパクの解析 単著 1999.06 ウイルス 49 61-79
An amino acid in the heptad repeat 1 domain is important for the haemagglutinin-neuraminidase-independent fusing activity of simian virus 5 fusion protein. 共著 2000.03 Journal of General Virology 81 719-727
Function of fusion regulatory proteins (FRPs) in immune cells and virus-infected cells. 共著 2000.03 Critical Reviews in Immunology 20 167-196
Hemagglutinin-neuraminidase-independent fusion activity of simian virus 5 fusion (F) protein: difference in conformation between fusogenic and nonfusogenic F proteins on the cell surface. 共著 2001.10 Journal of Virology 75 8999-9009
Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. 共著 2002.01 American Journal of Physiology Cell Physiology 282 196-204
Human osteosarcoma-derived cell lines produce soluble factor(s) that induces differentiation of blood monocytes to osteoclast-like cells. 共著 2002.01 International Immunopharmacology 2 25-38
Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1. 共著 2002.09 International Journal of Biochemistry and Cell Biology 34 1152-1163
Characterization of Sendai virus persistently infected L929 cells and Sendai virus pi strain.:recombinant Sendai viruses having Mpi protein shows lower cytotoxicity and are incapable of establishing persistent infection. 共著 2003.09 Virology 314 110-124
The targeted disruption of the CD98 gene results in embryonic lethality. 共著 2003.09 Biochimical and Biophysical Research Communications 308 847-851
Identification of amino acids essential for the human parainfluenza type 2 virus V protein to lower the intracellular levels of of the STAT2. 共著 2003.12 Virology 317 208-219
Early stage of establishment of persistent Sendai virus infection: unstable dynamic phase and then selection of viruses which are tightly cell associated, temperature sensitive, and capable of establishing persistent infection. 共著 2004.11 Journal of Virology 78 11939-11951
Recombinant Sendai viruses with L1618V mutation in their L polymerase protein establish persistent infection, but not temperature sensitivity. 共著 2004.11 Virology 329 289-301
The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formation. 共著 2004.11 Medical Microbiology and Immunology 193 155-162
Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication. 共著 2005.07 Journal of Virology 79 8591-8601
Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact. 共著 2005.09 Journal of Orthopaedic Research 23 979-987
Human parainfluenza virus type 4 is incapable of evading the interferon-induced antiviral effect. 共著 2005.12 Journal of Virology 79 14756-14768
ウイルスによる膜融合 単著 2005.12 ウイルス 55 207-220
A mutant fusion (F) protein of simian virus 5 induceshemagglutinin-neuraminidase-independent syncytium formation despite theinternalization of the F protein. 共著 2006.03 Virology 347 11-27
Identification of RNA-binding regions on the P and V proteins of Human parainfluenza virus type 2. 共著 2006.03 Medical Microbiology and Immunology 195 29-36
Possible activation of murine T lymphocyte through CD98 is independent of interleukin 2/interleukin 2 receptor system. 共著 2006.04 Biomedical Research 27 61-67
The properties of recombinant Sendai virus having the P gene of Sendai virus pi strain derived from BHK cells persistently infected with Sendai virus. 共著 2006.09 Medical Microbiology and Immunology 193 151-158
呼吸器粘膜の感染防御機構 共著 2006.10 日本臨牀 1808
The conserved carboxyl terminus of human parainfluenza virus type 2 V protein plays an important role in virus growth. 共著 2007.05 Virology 362 85-98
Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor. 共著 2007.05 General and Comparative Endocrinology 151 269-273
Failure of multinucleated giant cell formation in K562 cells infected with Newcastle disease virus and human parainfluenza type 2 virus. 共著 2007.06 Microbiology and Immunology 51 601-608
Human parainfluenza virus type 2 V protein inhibits genome replication by binding to the L protein: possible role in promoting viral fitness. 共著 2008.07 Journal of Virology 82 6130-6138
Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus. 共著 2008.09 Journal of Virology 82 8283-8295
Fucoidan inhibits parainfluenza virus type 2 infection to LLCMK2 cells. 共著 2008.12 Biomedical Research 29 331-334
Effects of multiple amino acids of the parainfluenza virus 5 fusion protein on the haemagglutinin- neuraminidase-independent fusion activity. 共著 2009.02 Journal of General Virology 90 405-413
Analysis of transgenic mice that have human CD98 heavy chain gene. 共著 2009.03 Cytologia 74 65-70
A quantitative method for analyzing establishing-efficiency of persistent viral infection. 共著 2009.05 Microbiology and Immunology 53 259-265
Completion of the full-length genome sequence of human parainfluenza virus types 4 A and 4B: sequence analyses of the large protein genes, and gene start, intergenic and end sequences. 共著 2010 Archives of Virology
Inhibitory effect of bovine lactofferrin on human parainfluenza virus type 2 infection. 共著 2010.05 Journal of Health Science 56 613-617
Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping. 共著 2011.01 Journal of Virology 85 725-732
Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the F protein in mediating cell-cell fusion. 共著 2011.04 Journal of Virology 85 3153-3161
Legume lectins inhibit human parainfluenza:virus type 2 infection by interfering with the entry. 共著 2012.06 Viruses 4 1104-1115
Intranasally administered antigen 85B gene vaccine in non-replicating:human parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis. 共著 2013.07 PLoS One 8
Full conversion of the hemagglutinin-neuraminidase specificity of the parainfluenza virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein. 共著 2013.08 Journal of Virology 87 8342-8350
Calcium ionophore A23187 inhibits human parainfluenza virus type 2 growth and monoclonal antibody against CD98 heavy chain recovers the inhibition. 共著 2014.02 International Journal of Sciences 3 14-20
Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector. 共著 2014.08 Gene Therapy 21 775-784
Ribavirin inhibits human parainfluenza virus type 2 replication in vitro. 共著 2014.11 Microbiology and Immunology 58 628-635
Inhibition of human parainfluenza virus type 2 growth in vitro by catechin is caused by the inhibition of genome and mRNA synthesis and by the disruption of cytoskeleton, and that by tannic acid is mainly caused by genome synthesis inhibition and the disruption of cytoskeleton. 共著 2014.12 International Journal of Sciences 3 47-55
Pathogenesis of the Influenza Virus in Diabetes:Model Mice 共著 2015.08 British Microbiology Research Journal 9 1-7
Enhanced growth of influenza A virus by coinfection with human parainfluenza virus type 2. Med Microbiol Immunol. 共著 2015.11 Medical Microbiology and Immunology
The fusion protein specificity of the parainfluenza virus hemagglutinin-neuraminidase protein is not solely defined by the primary structure of its stalk domain 共著 2015.12 Journal of Virology 90 12374-12387
The Springer Index of Viruses 2nd edition 共著 2011.08 Springer, New York
Negative Strand RNA Virus 単著or編著 2011.09 World Scientific
臨床検査Mook 28 ウイルスの臨床検査 共著 1988.02 金原出版
Viral Fusion Mechanisms 共著 1993.01 CRC press
ウイルス実験プロトコール 共著 1995.05 メジカルビュー社
The Springer Index of Viruses 共著 2001 Springer
科学研究費補助金特定領域研究報告書「感染の成立と宿主応答の分子基盤」 共著


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