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三重大学教員紹介

教員情報

職名
教授
氏名

ガバザ エステバン セサル
生年月
1958.09
所属
部局
医学系研究科
学科・専攻
生命医科学専攻
講座
基礎医学系講座
教育研究分野
 
TEL
 
FAX
 
E-mail
gabazza@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
 
学歴
医学部 学士課程 (~1984年)
博士課程・博士後期課程 (~1993年) 卒業・修了
学位
1993.12 医学博士 三重大学
所属学会
米国アレルギー 喘息免疫学会 米国胸部疾患学会, 欧州呼吸器疾患学会, 英国免疫学会 日本アレルギー学会 日本呼吸器疾患学会 日本感染症学会
社会活動
 
職歴
1985.02~1987.03 アスンシオン国立大学医学部附属病院 医員
1997.05~2006.11 三重大学医学部 助手
2006.12~ 三重大学 教授
学術(芸術)賞
 
専門分野
呼吸器疾患 癌 凝固系
現在の研究課題
T細胞特異的阻害剤の開発 アレルギー疾患における細胞外マトリクスの役割
担当科目
 
主な業績等
1.Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D'Alessandro-Gabazza CN, Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, Taguchi O, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T. Efficacy of a novel class of RNA interference therapeutic agents. PLoS One. 7:e42655, 2012
2.Boveda-Ruiz D, D'Alessandro-Gabazza CN, Toda M, Takagi T, Naito M, Matsushima Y, Matsumoto T, Kobayashi T, Gil-Bernabe P, Chelakkot-Govindalayathil AL, Miyake Y, Yasukawa A, Morser J, Taguchi O, Gabazza EC. Differential role of regulatory T cells in early and late stages of pulmonary fibrosis. Immunobiology. 2012 in press
3.Eagan TM, Gabazza EC, D Alessandro-Gabazza C, Gil-Bernabe P, Aoki S, Hardie JA, Bakke PS, Wagner PD. TNF-alpha is associated with loss of lean body mass only in already cachectic COPD patients. Respir Res. 13:48, 2012
4.Fujiwara A, Kobayashi H, Masuya M, Maruyama M, Nakamura S, Ibata H, Fujimoto H, Ohnishi M, Urawa M, Naito M, Takagi T, Kobayashi T, Gabazza EC, Takei Y, Taguchi O. Respirology. 17:693-8, 2012
5.Tsuda K, Yamanaka K, Kitagawa H, Akeda T, Naka M, Niwa K, Nakanishi T, Kakeda M, Gabazza EC, Mizutani H. Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells. PLoS One.7:e31465, 2012
6.Suzuki T, Yano Y, Sakamoto M, Uemura M, Yasuma T, Onishi Y, Sasaki R, Matsumoto K, Hayashi T, Maruyama-Furuta N, Akatsuka H, Gabazza EC, Sumida Y, Takei Y. Correlation of circulating dehydroepiandrosterone with activated protein C generation and carotid intima-media thickness in male patients with Type 2 diabetes. Diabet Med. 29:e41-6, 2012
7.Gil-Bernabe P, D'Alessandro-Gabazza CN, Toda M, Boveda Ruiz D, Miyake Y, Suzuki T, Onishi Y, Morser J, Gabazza EC, Takei Y, Yano Y. Exogenous activated protein C inhibits the progression of diabetic nephropathy. J Thromb Haemost. 10:337-46, 2012
8.Kakeda M, Yamanaka K, Kitagawa H, Tsuda K, Akeda T, Kurokawa I, Gabazza EC, Mizutani H. Heat-killed bacillus Calmette-Guérin and Mycobacterium kansasii antigen 85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells. Br J Dermatol. 166:953-63, 2012
9.Fujiwara A, Taguchi O, Takagi T, D'Alessandro-Gabazza CN, Boveda-Ruiz D, Toda M, Yasukawa A, Matsushima Y, Miyake Y, Kobayashi H, Kobayashi T, Gil-Bernabe P, Naito M, Yoshida M, Morser J, Takei Y, Gabazza EC. Role of thrombin-activatable fibrinolysis inhibitor in allergic bronchial asthma. Lung. 190:189-98, 2012
10.D'Alessandro-Gabazza CN, Kobayashi T, Boveda-Ruiz D, Takagi T, Toda M, Gil-Bernabe P, Miyake Y, Yasukawa A, Matsuda Y, Suzuki N, Saito H, Yano Y, Fukuda A, Hasegawa T, Toyobuku H, Rennard SI, Wagner PD, Morser J, Takei Y, Taguchi O, Gabazza EC. Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis. Am J Respir Cell Mol Biol. 46:397-406. 2012
11.Mizutani H, Akeda T, Yamanaka K, Isoda K, Gabazza EC. Single step modified ink staining for Tzanck test: quick detection of herpetic giant cells in Tzanck smear. J Dermatol. Feb;39:138-40, 2012
12.Tsuda K, Yamanaka K, Linan W, Miyahara Y, Akeda T, Nakanishi T, Kitagawa H, Kakeda M, Kurokawa I, Shiku H, Gabazza EC, Mizutani H. Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses. PLoS One. 6:e29020, 2011
13.Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Toda M, Miyake Y, Mifuji-Moroka R, Iwasa M, Morser J, Gabazza EC, Takei Y. Atherosclerosis amelioration by moderate alcohol consumption is associated with increased circulating levels of stromal cell-derived factor-1. Circ J. 75:2269-79, 2011
14.Shimizu S, Gabazza EC, Ogawa T, Tojima I, Hoshi E, Kouzaki H, Shimizu T. Role of thrombin in chronic rhinosinusitis-associated tissue remodeling. Am J Rhinol Allergy. 25:7-11, 2011
15.Takagi T, Taguchi O, Toda M, Ruiz DB, Bernabe PG, D'Alessandro-Gabazza CN, Miyake Y, Kobayashi T, Aoki S, Chiba F, Yano Y, Conway EM, Munesue S, Yamamoto Y, Yamamoto H, Suzuki K, Takei Y, Morser J, Gabazza EC. Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells. Am J Respir Crit Care Med. 183:31-42, 2011
16.Beppu T, Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Matsuda Y, Toda M, Miyake Y, Shiraki K, Murata M, Murata T, Yano Y, Morser J, Gabazza EC, Takei Y. High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double-deficient mice. J Thromb Haemost. 8:2514-22, 2010
17.Omoto Y, Yamanaka K, Tokime K, Kitano S, Kakeda M, Akeda T, Kurokawa I, Gabazza EC, Tsutsui H, Katayama N, Yamanishi K, Nakanishi K, Mizutani H. Granzyme B is a novel interleukin-18 converting enzyme. J Dermatol Sci. 59:129-35, 2010
18.Maruyama T, Taguchi O, Niederman MS, Morser J, Kobayashi H, Kobayashi T, D'Alessandro-Gabazza C, Nakayama S, Nishikubo K, Noguchi T, Takei Y, Gabazza EC. Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents: double blind, randomised and placebo controlled trial. BMJ. 340:c1004, 2010
19.Yamanaka KI, Kakeda M, Kitagawa H, Tsuda K, Akeda T, Kurokawa I, Gabazza EC, Kupper TS, Mizutani H. 1,24-Dihydroxyvitamin D₃ (tacalcitol) prevents skin T-cell infiltration. Br J Dermatol. 162:1206-15, 2010
20.Morser J, Gabazza EC, Myles T, Leung LL. What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse? J Thromb Haemost. 8:868-76, 2010
21.Qin L, D'Alessandro-Gabazza CN, Aoki S, Gil-Bernabe P, Yano Y, Takagi T, Boveda-Ruiz D, Ramirez Marmol AY, San Martin Montenegro VT, Toda M, Miyake Y, Taguchi O, Takei Y, Morser J, Gabazza EC. Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost. 8:808-16, 2010
22.Maruyama T, Gabazza EC, Morser J, Takagi T, D'Alessandro-Gabazza C, Hirohata S, Nakayama S, Ramirez AY, Fujiwara A, Naito M, Nishikubo K, Yuda H, Yoshida M, Takei Y, Taguchi O. Community-acquired pneumonia and nursing home-acquired pneumonia in the very elderly patients. Respir Med. 104:584-92, 2010
23.Takagi T, Taguchi O, Aoki S, Toda M, Yamaguchi A, Fujimoto H, Boveda-Ruiz D, Gil-Bernabe P, Ramirez AY, Naito M, Yano Y, D'Alessandro-Gabazza CN, Fujiwara A, Takei Y, Morser J, Gabazza EC. Direct effects of protein S in ameliorating acute lung injury. J Thromb Haemost. 7:2053-63, 2009
24.Yamanaka K, Yuta A, Kakeda M, Sasaki R, Kitagawa H, Gabazza EC, Okubo K, Kurokawa I, Mizutani H. Induction of IL-10-producing regulatory T cells with TCR diversity by epitope-specific immunotherapy in pollinosis. J Allergy Clin Immunol. 124:842-5.e7, 2009
25.Takagi T, Morser J, Gabazza EC, Qin L, Fujiwara A, Naito M, Yamaguchi A, Kobayashi T, D'Alessandro-Gabazza CN, Boveda Ruiz D, Gil Bernabe P, Iwasaki Y, Takei Y, Taguchi O. The coagulation and protein C pathways in patients with sleep apnea. Lung. 187:209-13, 2009
26.Morioka T, Yamanaka K, Mori H, Omoto Y, Tokime K, Kakeda M, Kurokawa I, Gabazza EC, Tsubura A, Yasutomi Y, Mizutani H IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis. Br J Dermatol. 160:1172-9, 2009
27.Sugisaki H, Yamanaka K, Kakeda M, Kitagawa H, Tanaka K, Watanabe K, Gabazza EC, Kurokawa I, Mizutani H. Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease. J Dermatol Sci. 55:47-52, 2009
28.Ikeda A, Gabazza EC, Morser J, Imoto I, Kuroda M, D'Alessandro-Gabazza CN, Hara K, Ruiz DB, Bernabe PG, Katsurahara M, Toda M, Kobayashi Y, Yano Y, Sumida Y, Suzuki K, Taguchi O, Takei Y. Presence of thrombin-activatable fibrinolysis inhibitor in Helicobacter pylori-associated gastroduodenal disease. Helicobacter. 14:147-55, 2009
29.Maruyama T, Takei Y, Gabazza EC, Morser J, Taguchi O. Different bile concentration of micafungin and itraconazole in a patient with candidal cholecystitis. J Infect. 58:315-6, 2009
30.Okamoto T, Akiyama M, Takeda M, Gabazza EC, Hayashi T, Suzuki K. Connexin32 is expressed in vascular endothelial cells and participates in gap-junction intercellular communication. Biochem Biophys Res Commun. 382:264-8, 2009
31.Saito K, Torii M, Ma N, Tsuchiya T, Wang L, Hori T, Nagakubo D, Nitta N, Kanegasaki S, Hieshima K, Yoshie O, Gabazza EC, Katayama N, Shiku H, Kuribayashi K, Kato T. Differential regulatory function of resting and preactivated allergen-specific CD4+ CD25+ regulatory T cells in Th2-type airway inflammation. J Immunol. 181:6889-97, 2008
32.Shimizu S, Shimizu T, Morser J, Kobayashi T, Yamaguchi A, Qin L, Toda M, D'Alessandro-Gabazza C, Maruyama T, Takagi T, Yano Y, Sumida Y, Hayashi T, Takei Y, Taguchi O, Suzuki K, Gabazza EC. Role of the coagulation system in allergic inflammation in the upper airways. Clin Immunol. 129:365-71, 2008
33.Kishiwada M, Hayashi T, Yuasa H, Fujii K, Nishioka J, Akita N, Tanaka H, Ido M, Okamoto T, Gabazza EC, Isaji S, Suzuki K. Regulatory mechanisms of C4b-binding protein (C4BP)alpha and beta expression in rat hepatocytes by lipopolysaccharide and interleukin-6. J Thromb Haemost. 6:1858-67, 2008
34.Bruno NE, Yano Y, Takei Y, Qin L, Suzuki T, Morser J, D'Alessandro-Gabazza CN, Mizoguchi A, Suzuki K, Taguchi O, Gabazza EC, Sumida Y. Immune complex-mediated glomerulonephritis is ameliorated by thrombin-activatable fibrinolysis inhibitor deficiency. Thromb Haemost. 100:90-100, 2008
35.Maruyama T, Niederman MS, Kobayashi T, Kobayashi H, Takagi T, D'Alessandro-Gabazza CN, Fujimoto H, Gil Bernabe P, Hirohata S, Nakayama S, Nishikubo K, Yuda H, Yamaguchi A, Gabazza EC, Noguchi T, Takei Y, Taguchi O. A prospective comparison of nursing home-acquired pneumonia with hospital-acquired pneumonia in non-intubated elderly. Respir Med. 102:1287-95, 2008
36.Yamaguchi A, Gabazza EC, Takei Y, Yano Y, Fujimoto H, D'Alessandro-Gabazza CN, Murakami E, Kobayashi T, Takagi T, Maruyama J, Suzuki K, Taguchi O. Role of thrombin in interleukin-5 expression from basophils. Biochem Biophys Res Commun. 368:116-20, 2008
37.Hamada T, Kamada H, Hayashi T, Nishioka J, Gabazza EC, Isaji S, Uemoto S, Suzuki K. Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice. Gut. 57:365-73, 2008
38.Bruno NE, Yano Y, Takei Y, Gabazza EC, Qin L, Nagashima M, Morser J, D'Alessandro-Gabazza CN, Taguchi O, Sumida Y. Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis. J Thromb Haemost. 6:139-46, 2008



更新日 2013-06-20
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