三重大学教員紹介

職名

教授

氏名

のさかてつや
野阪哲哉

生年月

1961.03

所属	部局	医学系研究科
	学科・専攻	生命医科学専攻
	講座	基礎医学系講座
	教育研究分野	感染症制御医学・分子遺伝学分野

TEL

FAX

E-mail

nosaka@doc.medic. (末尾に mie-u.ac.jp を補ってください)

個人のホームページ

http://www.medic.mie-u.ac.jp/microbiol/

学歴

三重大学医学部医学科学士課程 (～1985年)
京都大学大学院医学研究科分子医学系博士課程博士課程・博士後期課程 (～1989年) 卒業・修了

学位

1989.03 医学博士京都大学

所属学会

日本血液学会日本癌学会　アメリカ血液学会　アメリカ微生物学会

社会活動

職歴

1989.04～1996.11 京都大学ウイルス研究所文部教官助手
1996.12～1999.10 　東京大学医科学研究所寄付研究部門助手
1999.11～2006.11 　東京大学医科学研究所寄付研究部門助教授
2006.12～三重大学大学院医学系研究科教授

学術（芸術）賞

三医会賞
ASH Merit Award (American Society of Hematology)
日本血液学会奨励賞
日本白血病研究基金・一般研究賞

専門分野

分子生物学　ウイルス学　血液学

現在の研究課題

白血病発症の分子機構
次世代型遺伝子組換えワクチン開発
免疫活性化抗腫瘍ウイルス開発

担当科目

感染症の微生物学（チュートリアル）生命医科学の現代的課題微生物学分子生命体科学

主な業績等

主要論文　筆頭著者

Nosaka T, van Deursen JMA, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN. Defective lymphoid development in mice lacking JAK3. Science 270: 800-802, 1995.

Nosaka T, Kawashima T, Misawa K, Ikuta K, Mui AL-F, Kitamura T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J 18: 4754-4765, 1999.

Nosaka T, Siomi H, Adachi Y, Ishibashi M, Kubota S, Maki M, Hatanaka M. Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA. Proc Natl Acad Sci USA 86: 9798-9802, 1989.

Nosaka T, Morita S, Kitamura H, Nakajima H, Shibata F, Morikawa Y, Kataoka Y, Ebihara Y, Kawashima T, Itoh T, Ozaki K, Senba E, Tsuji K, Makishima F, Yoshida N, Kitamura T. Mammalian Twisted gastrulation is essential for skeleto-lymphogenesis. Mol Cell Biol 23: 2969-2980, 2003.

Nosaka T, Ohno H, Doi S, Fukuhara S, Miwa H, Kita K, Shirakawa S, Honjo T, Hatanaka M. Phenotypic conversion of T-lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts: Molecular genetic evidence of the same clonal origin. J Clin Invest 81: 1824-1828, 1988.

Nosaka T, Kita K, Miwa H, Kawakami K, Ikeda T, Ohno T, Matsuoka N, Arita Y, Doi S, Nishikori M, Matsuda F, Lee KH, Shirakawa S, Honjo T, Hatanaka M. Cross-lineage gene rearrangements of human leukemic Ｂ-precursor cells occur frequently with V-DJ rearrangements of IgH genes. Blood 74: 361-368, 1989.

Nosaka T, Ariumi Y, Sakurai M, Takeuchi R, Hatanaka M. Novel internal promoter/enhancer of HTLV-I for Tax expression. Nucl Acids Res 21: 5124-5129, 1993.

Nosaka T, Takamatsu T, Miyazaki Y, Sano K, Sato A, Kubota S, Sakurai M, Ariumi Y, Nakai M, Fujita S, Hatanaka M. Cytotoxic activity of rev protein of human immunodeficiency virus type 1 by nucleolar dysfunction. Exp Cell Res 209: 89-102, 1993.

Nosaka T, Miyazaki Y, Takamatsu T, Sano K, Nakai M, Fujita S, Martin TE, Hatanaka M. The post-transcriptional regulator Rex of the human T-cell leukemia virus type I is present as nucleolar speckles in infected cells. Exp Cell Res 219: 122-129, 1995.

Brown MP*, Nosaka T*, Tripp RA, Brooks J, van Deursen JMA, Brenner MK, Doherty PC, Ihle JN. Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3. Blood 94: 1906-1914, 1999 (*Equal first authors).

Nosaka T, Kitamuta T. Pim-1 expression is sufficient to induce cytokine independence in murine hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation. Exp Hematol 30: 697-702, 2002.

主要論文　Last Author または　責任著者

Ono R, Nakajima H, Ozaki K, Kumagai H, Kawashima T, Taki T, Kitamura T, Hayashi Y, Nosaka T. Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple lineage leukemogenesis. J Clin Invest 115: 919-929, 2005.

Urano A, Endoh M, Wada T, Morikawa Y, Itoh M, Kataoka Y, Taki T, Akazawa H, Nakajima H, Komuro I, Yoshida N, Hayashi Y, Handa H, Kitamura T, Nosaka T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol Cell Biol 25: 6834-6845, 2005.

Ono R, Ihara M, Nakajima H, Ozaki K, Kataoka-Fujiwara Y, Taki T, Nagata K, Inagaki M, Yoshida N, Kitamura T, Hayashi Y, Kinoshita M, Nosaka T. Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4. Mol Cell Biol 25: 10965-10978, 2005.

Hiwatari M, Ono R, Taki T, Hishiya A, Ishii E, Kitamura T, Hayashi Y, Nosaka T. Novel gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute lymphoblastic leukemia with t(4;11)(q21;q23). Leukemia 22: 2279-2280, 2008.

Ono R, Kumagai H, Nakajima H, Hishiya A, Taki T, Horikawa K, Takatsu K, Satoh T, Hayashi Y, Kitamura T, Nosaka T. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia 23: 2197-2209, 2009.

Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura T, Nosaka T. Expression of ADAMTS4 in Ewing’s sarcoma. Int J Oncol 37: 569-581, 2010.

Suzuki K, Ono R, Ohishi K, Masuya M, Kataoka I, Liu B, Nakamori Y, Ino K, Monma F, Hamada H, Kitamura T, Katayama N, Nosaka T. IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells. Int J Oncol 40: 53-62, 2012.

Tsurudome M, Nakahashi M, Matsushima Y,Ito M, Nishio M, Kawano M, Komada H, Nosaka T. Full conversion of the hemagglutinin-neuraminidase specificity of the parainfluenza　virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein. J Virol 87: 8342-8350, 2013.

Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, Suzuki K, Shibata-Minoshima F, Katayama N, Kitamura T, Nosaka T. Plzf drives MLL-fusion-mediated leukemogenesis specifically in long term hematopoietic stem cells. Blood 122: 1271-1283, 2013.

Hara K, Fukumura M, Ohtsuka J, Kawano M, Nosaka T. Human Parainfluenza virus type 2 vector induces dendritic cell maturation without viral RNA replication/transcription. Hum Gene Ther 24: 683-691, 2013.

Ohtsuka J, Fukumura M, Tsurudome M, Hara K, Nishio M, Kawano M, Nosaka T. Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector. Gene Ther 21:775-784, 2014.　

Tsurudome M, Ito M, Ohtsuka J, Hara K, Komada H, Nishio M, Nosaka T. The fusion protein specificity of the parainfluenza virus hemagglutinin-neuraminidase protein is not solely defined by the primary structure of its stalk domain. J Virol 89: 12374-12387, 2015.

Ono R, Masuya M, Ishii S, Katayama N, Nosaka T. Eya2, a target activated by Plzf, is critical for PLZF-RARA-induced leukemogenesis. Mol Cell Biol 37:e00585-16, 2017.

Tsurudome M, Ohtsuka J, Ito M, Nishio M, Nosaka T. The hemagglutinin-neuraminidase (HN) head domain and the fusion (F) protein stalk domain of the parainfluenza viruses affect the specificity of the HN-F interaction. Front Microbiol 9: 391, 2018.

Maharjan BD, Ono R, Nosaka T. Eya2 is critical for the E2A-HLF-mediated immortalization of mouse hematopoietic stem/progenitor cells. Int J Oncol 54: 981-990, 2019.

Ohtsuka J, Fukumura M, Furuyama W, Wang S, Hara K, Maeda M, Tsurudome M, Miyamoto H, Kaito A, Tsuda N, Kataoka Y, Mizoguchi A, Takada A, Nosaka T. A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector. Sci Rep 9: 12901, 2019.

Ono R, Masuya M, Inoue N, Shinmei M, Ishii S, Maegawa Y, Mahrjan BD, Katayama N, Nosaka T. Tett1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models. PLos ONE 16: e0248425, 2021.　

主要論文　2nd author

Kubota S, Nosaka T, Cullen BR, Maki M, Hatanaka M. Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals. J Virol 65: 2452-2456, 1991.

White KN, Nosaka T, Kanamori H, Hatanka M, Honjo T. The nucleolar localisation signal of the HTLV-I protein p27rex is important for stabilisation of IL-2 receptor  subunit mRNA by p27rex. Biochem Biophys Res Commun 175: 98-103, 1991.

Ueba T, Nosaka T, Takahashi JA, Shibata F, Florkiewicz RZ, Vogelstein B, Oda Y, Kikuchi H, Hatanaka M. Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. Proc Natl Acad Sci USA 91: 9009-9013, 1994.

Ihle JN, Nosaka T, Thierfelder W, Quelle FW, Shimoda K. Jaks and Stats in cytokine signaling. Stem Cells 15 Suppl 1: 105-112, 1997.

Misawa K, Nosaka T, Morita S, Kaneko A, Nakahata T, Asano S, Kitamura T. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci USA 97: 3062-3066, 2000.

Onishi M, Nosaka T, Misawa K, Mui ALF, Gorman D, McMahon M, Miyajima A, Kitamura T. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol 18: 3871-3879, 1998.

Fujio K, Nosaka T, Kojima T, Kawashima T, Yahara T, Copeland NG, Gilbert DJ, Jenkins NA, Yamamoto K, Nishimura T, Kitamura T. Molecular cloning of a novel type I cytokine receptor similar to the common gamma chain. Blood 95: 2204-2211, 2000.

Ariyoshi K, Nosaka T, Yamada K, Onishi M, Oka Y, Miyajima A, Kitamura T. Constitutive activation of STAT5 by a point mutation in the SH2 domain. J Biol Chem 275; 24407-24413, 2000.

Ikeya M, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y. Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice. Mech Dev 125: 832-842, 2008.

主要論文　共著

Siomi H, Shida H, Nam SH, Nosaka T, Maki M, Hatanaka M. Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing. Cell 55: 197-209, 1988.

Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DAA, Doherty PC, Grosveld G, Paul WE, Ihle JN. Lack of interleukin-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380: 630-633, 1996.

Tanaka A, Takahashi C, Yamaoka S, Nosaka T, Maki M, Hatanaka M. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc Natl Acad Sci USA 87: 1071-1075, 1990.

Kanamori H, Suzuki N, Siomi H, Nosaka T, Sato A, Sabe H, Hatanaka M, Honjo T. HTLV-I p27rex stabilizes human interleukin-2 receptor alpha-chain mRNA. EMBO J 9: 4161-4166, 1990.

Nakajima T, Aono H, Hasunuma T, Yamamoto K, Maruyama I, Nosaka T, Hatanaka M, Nishioka K. Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene. J Clin Invest 92: 186-193, 1993.

Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 16: 1622-1631, 1996.

Morikawa Y, Nishida H, Misawa K, Nosaka T, Miyajima A, Senba E, Kitamura T. Induction of synaptosomal-associated protein-23 kd (SNAP-23) by various cytokines. Blood 92: 129-135, 1998.

Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, Nosaka T, Kitamura T. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood 96: 2116-2124, 2000.

Minoshima Y, Kawashima T, Hirose K, Tonozuka Y, Kawajiri A, Bao YC, Deng X, Tatsuka M, Narumiya S, May WS Jr, Nosaka T, Semba K, Inoue T, Satoh T, Inagaki M, Kitamura T. Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell 4: 549-560, 2003.

Ikeda Y, Imai Y, Kumagai H, Nosaka T, Morikawa Y, Hisaoka T, Manabe I, Maemura K, Nakaoka T, Imamura T, Miyazono K, Komuro I, Nagai R, Kitamura T. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc Natl Acad Sci USA 101: 10732-10737, 2004.

Tonozuka Y, Minoshima Y, Bao YC, Moon Y, Tsubono Y, Hatori T, Nakajima H, Nosaka T, Kawashima T, Kitamura T. A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line. Blood 104: 3550-3557, 2004.

Kawashima T, Bao YC, Moon Y, Tonozuka Y, Minoshima Y, Hatori T, Kiyono M, Nosaka T, Nakajima H, Williams DA, Kitamura T. Rac 1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors. J Cell Biol 175: 937-946, 2006.

Ohno T, Kanoh T, Arita Y, Fujii H, Kuribayashi K, Matsuda T, Horiguchi Y, Taniwaki M, Nosaka T, Hatanaka M, Uchino H. Fulminant clonal expansion of large granular lymphocytes. Characterization of their morphology, phenotype, genotype, and function. Cancer 62: 1918-1927, 1988.

Hatabu H, Kasagi K, Iida Y, Nosaka T, Misaki T, Hidaka A, Tokuda Y, Endo K, Mori T, Lee K, Tsuboi K, Hatanaka M, Konishi J. Induction of c-fos and c-myc mRNA expression by immunoglobulin G from patients with Graves’ disease in thyrotrophin-dependent rat thyroid cell line (FRTL5). Clin Endocrinol 34: 349-356, 1991.

Adachi Y, Copeland TD, Takahashi C, Nosaka T, Ahmed A, Oroszlan S, Hatanaka M. Phosphorylation of the Rex protein of human T-cell leukemia virus type I. J Biol Chem 267: 21977-21981, 1992.

Sakurai M, Yamaoka S, Nosaka T, Akayama M, Tanaka A, Maki M, Hatanaka M. Transforming activity and the level of Tax protein: Effect of one point mutation in HTLV-I tax gene. Int J Cancer 52: 323-328, 1992.

Miyazaki Y, Takamatsu T, Nosaka T, Fujita S, Hatanaka M. Intranuclear topological distribution of HIV-1 trans-activators. FEBS Lett 305: 1-5, 1992.

Miyazaki Y, Takamatsu T, Nosaka T, Fujita S, Martin TE, Hatanaka M. The cytotoxicity of human immunodeficiency virus type 1 Rev: Implications for its interaction with the nucleolar protein B23. Exp Cell Res 219: 93-101, 1995.

Sohn SJ, Forbush KA, Nguyen N, Witthuhn B, Nosaka T, Ihle JN, Perlmutter RM. Requirement for Jak3 in mature T-cells: Its role in regulation of T cell homeostasis. J Immunol 160: 2130-2138, 1998.

Habu K, Nakayama-Yamada J, Asano M, Saijo S, Itagaki K, Horai R, Yamamoto H, Sekiguchi T, Nosaka T, Hatanaka M, Iwakura Y. The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice. J Immunol 162: 2956-2963, 1999.

Fujio K, Misaki Y, Setoguchi K, Morita S, Kawahata K, Kato I, Nosaka T, Yamamoto K, Kitamura T. Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the  TCR complex. J Immunol 165: 528-532, 2000.

Sugiyama T, Kumagai H, Morikawa Y, Wada Y, Sugiyama A, Yasuda K, Yokoi N, Tamura S, Kojima T, Nosaka T, Senba E, Kimura S, Kadowaki T, Kodama T, Kitamura T. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched -VLDL in vitro. Biochemistry 39: 15817-15825, 2000.

Hirose K, Kawashima T, Iwamoto I, Nosaka T, Kitamura T. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J Biol Chem 276: 5821-5828, 2001.

Kawashima T, Murata K, Akira S, Tonozuka Y, Minoshima Y, Feng S, Kumagai H, Tsuruga H, Ikeda Y, Asano S, Nosaka T, Kitamura T. STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-B p65. J Immunol 167: 3652-3660, 2001.

Murata K, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H, Suzu S, Shibuya M, Kamihira S, Nosaka T, Asano S, Kitamura T. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem 278: 32892-32898, 2003.

Kitamura T, Koshino Y, Shibata F, Oki T, Nakajima H, Nosaka T, Kumagai H. Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics. Exp Hematol 31: 1007-1014, 2003.

Lu Y, Kitaura J, Oki T, Komeno Y, Ozaki K, Kiyono M, Kumagai H, Nakajima H, Nosaka T, Aburatani H, Kitamura T. Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia 21: 2246-2257, 2007.

Matsushita H, Nakajima H, Nakamura Y, Tsukamoto H, Tanaka Y, Jin G, Yabe M, Asai S, Ono R, Nosaka T, Sugita K, Morimoto A, Hayashi Y, Hotta T, Ando K, Miyachi H. C/EBPand C/EBP induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene. Oncogene 27: 6749-6760, 2008.

Watanabe-Okochi N, Kitaura J, Ono R, Harada H, Harada Y, Komeno Y, Nakajima H, Nosaka T, Inaba T, Kitamura T. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood 111: 4297-4308. 2008.

Nishio M, Ohtsuka J, Tsurudome M, Nosaka T, Kolakofsky D. Human parainfluenza virus type 2 V protein inhibits genome replication by binding to the L protein; a possible role in promoting viral fitness. J Virol 82: 6130-6138, 2008.

Kawashima T, Bao YC, Minoshima Y, Nomura Y, Hatori T, Hori T, Fukagawa T, Fukada T, Takahashi N, Nosaka T, Inoue M, Sato T, Kukimoto-Niino M, Shirouzu, M, Yokoyama S, Kitamura T. A Rac GTPase activating protein MgcRacGAP is an NLS-containing nuclear chaperone in the activation of STAT transcription factors. Mol Cell Biol 29: 1796-1813, 2009.

Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y. Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. Dev Biol 337: 405-414, 2010.

Nishio M, Tsurudome M, Garcin D, Komada H, Ito M, Le Mercier P, Nosaka T, Kolakofsky D. Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping. J Virol 85: 725-732, 2011.

Tsurudome M, Ito M, Nishio M, Nakahashi M, Kawano M, Komada H, Nosaka T, Ito Y. Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the F protein in mediating cell-cell fusion. J Virol 85: 3153-3161, 2011.

Komori T, Doi A, Nosaka T, Furuta H, Akamizu T, Kitamura T, Senba E, Morikawa Y. Regulation of AMP-activated Protein Kinase Signaling by AFF4, a Member of the AF4 (ALL1-fused Gene from Chromosome 4) Family of Transcription Factors, in Hypothalamic Neurons. J Biol Chem 287: 19985-19996, 2012.　

Takeuchi T, Yamaguchi M, Kobayashi K, Miyazaki K, Tawara I, Imai H, Ono R, Nosaka T, Tanaka K, Katayama N. MYD88, CD79B, and CARD11 gene mutations in CD5-positive diffuse large B-cell lymphoma. Cancer 123: 1166-1173, 2017.

Ohtsuka J, Matsumoto Y, Ohta K, Fukumura M, Tsurudome M, Nosaka T, Nishio M. Nucleocytoplasmic shuttling of the human parainfluenza virus type 2 phosphoprotein. Virology　528: 54-63, 2019.

D'Alessandro-Gabazza CN, Kobayashi T, Yasuma T, Toda M, Kim H, Fujimoto H, Hataji O, Takeshita A, Nishihama K, Okano T, Okano Y, Nishii Y, Tomaru A, Fujiwara K, D'Alessandro VF, Abdel-Hamid AM, Ren Y, Pereira GV, Wright CL, Hernandez A, Fields CJ, Yau PM, Wang S, Mizoguchi A, Fukumura M, Ohtsuka J, Nosaka T, Kataoka K, Kondoh Y, Wu J, Kawagishi H, Yano Y, Mackie RI, Cann I, Gabazza EC. A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis. Nat Commun 11:1539, 2020.

その他　論文

Siomi H, Nosaka T, Saida T, Miwa H, Hinuma Y, Shirakawa S, Miyamoto N, Kondo T, Araki K, Ichimaru M, Miura AB, Hatanaka M. Two major subgroups of HTLV-I in Japan. Virus Genes 1: 377-383, 1988.

Miwa H, Nosaka T, Kita K, Ohno T, Matsuoka N, Shirakawa S, Arita Y, Doi S, Nishikori M, Honjo T, Hatanaka M. Immunogenotypes of lymphoid malignancies; the rearrangement of the T cell receptor  chain gene can occur before the chain gene rearrangement. Jpn J Cancer Res 79: 484-490, 1988.

Kamesaki H, Fukuhara S, Uchino H, Nosaka T. A new hypothesis on the cellular origin of Reed-Sternberg and Hodgkin cells based on the immunological and molecular genetic analysis of the KM-H2 line. Recent Results in Cancer Res 117: 83-90, 1989.

Miwa H, Kita K, Nosaka T, Kawakami K, Ikeda T, Shirakawa S. A mechanism for cross-lineage gene rearrangements in B-cell neoplasm. Acta Haematol Jpn 52: 1442-1450, 1989.

Adachi Y, Nosaka T, Hatanaka M. Protein kinase inhibitor H-7 blocks accumulation of unspliced mRNA of human T-cell leukemia virus type I (HTLV-I). Biochem Biophys Res Commun 169: 469-475, 1990.

Ikeda T, Kita K, Miwa H, Kawakami K, Anazawa H, Ohno T, Nosaka T, Hatanaka M, Honjo T, Shirakawa S. Genetic heterogeneity in blast crisis of chronic myelocytic leukemia. Leukemia Res 14: 195-201, 1990.

Arita Y, Kita K, Nasu K, Doi S, Fukuhara S, Nishikori M, Miwa H, Tatsumi E, Nosaka T, Hatanaka M, Uchino H. Frequent expression of myeloid antigen (CD13) on immature T cells in culture. Acta Haematol Jpn 53: 21-34, 1990.

Kubota S, Nosaka T, Furuta R, Maki M, Hatanaka M. Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation. Biochem Biophys Res Commun 178: 1226-1232, 1991.

Miwa H, Kita K, Nosaka T, Ikeda T, Kawakami K, Anazawa H, Hoshino K, Ohno T, Honjo T, Hatanaka M, Shirakawa S. Maturational stage specific immunoglobulin heavy chain gene rearrangements, determined by D and D upstream region gene structures. Leukemia Res 16: 861-871, 1992.

Kawakami K, Kita K, Miwa H, Ikeda T, Nishii K, Masuya M, Morita N, Ohno T, Tanaka I, Nosaka T, Honjo T, Shirakawa S. Rearrangement patterns of immunoglobulin heavy chain (IgH) and light chain genes in acute lymphoblastic leukemia and chronic myelocytic leukemia lymphoid crisis cells showing oligoclonal IgH gene rearrangements. Int J Hematol 55: 61-69, 1992.

Takano E, Nosaka T, Lee WJ, Nakamura K, Takahashi T, Funaki M, Okada H, Hatanaka M, Maki M. Molecular diversity of calpastatin in human erythroid cells. Arch Biochem Biophys 303: 349-354, 1993.

Tanabe S, Fukuhara S, Yoneda T, Ohmori K, Nosaka T, Hatanaka M, Okuma M. Characterization of a novel biphenotypic leukemia cell line, TA-1, with myeloperoxidase and inducible cytoplasmic chain: Altered rearrangement patterns of antigen receptor genes. Int J Hematol 57: 229-243, 1993.

Miyazaki Y, Nosaka T, Hatanaka M. The post-transcriptional regulator Rev of HIV: Implications for its interaction with the nucleolar protein B23. Biochimie 78: 1081-1086, 1996.

Ariumi Y, Copeland TD, Nosaka T, Hatanaka M. HIRF: a novel nuclear factor that binds to the human T-cell leukemia virus type I internal regulatory element (HIRE). Leukemia 11 Suppl 3: 29-31, 1997.

Yamada K, Ariyoshi K, Onishi M, Miyajima A, Hayakawa F, Towatari M, Saito H, Oka Y, Asano S, Nosaka T, Kitamura T. Constitutively active STAT5A and STAT5B in vitro and in vivo: mutation of STAT5 is not a frequent cause of leukemogenesis. Int J Hematol 71: 46-54, 2000.

Misawa K, Nosaka T, Kojima T, Hirai M, Kitamura T. Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily. Cytogenet Cell Genet 89: 89-91, 2000.

Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T. Molecular cloning of a human novel type I cytokine receptor related to 1/TSLPR. Cytogenet Cell Genet 93: 23-25, 2001.

Tulin EE, Onoda N, Maeda M, Hasegawa M, Nosaka T, Nomura H, Asano S, Kitamura T. A novel secreted form of immune suppressor factor with high homology to vacuolar ATPases identified by a forward genetic approach of functional screening based on cell proliferation. J Biol Chem 276: 27519-27526, 2001.

Tulin EE, Onoda N, Hasegawa M, Nosaka T, Nomura H, Kitamura T. Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation. Exp Cell Res 272: 23-31, 2002.

Ozaki K, Hishiya A, Hatanaka K, Nakajima H, Wang G, Hwu P, Kitamura T, Ozawa K, Leonard WJ, Nosaka T. Overexpression of Interleukin 21 induces expansion of hematopoietic progenitor cells. Int J Hematol 84: 224-230, 2006.

Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R, Harada Y, Harada H, Hayashi Y, Nakajima H, Nosaka T, Kitaura J, Kitamura T. Possible involvement of RasGRP4 in leukemogenesis. Int J Hematol 89: 470-481, 2009.

Jin G, Matsushita H, AsaiS, Tsukamoto H, Ono R, Nosaka T, Yahata T, Takahashi S, Miyachi H. FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression. Biochem Biophys Res Commun 390: 1001-1006, 2009.

Nagai Y, Iwade Y, Hayakawa E, Nakano M, Sakai T, Tanuma M, Katayama M, Nosaka T, Yamaguchi T. Molecular genotyping of Mycobacterium tuberculosis in Mie Prefecture, Japan, using variable numbers of tandem repeats analysis. Jpn J Infect Dis 65: 341-344, 2012.

Liu B, Ohishi K, Orito Y, Nakamori Y, Nishikawa H, Ino K, Suzuki K, Matsumoto T, Masuya M, Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N. Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy. Exp Hematol 41: 367-376, 2013.

Kitagawa H, Kawano M, Yamanaka K, Kakeda M, Tsuda K, Inada H, Yoneda M, Sakaguchi T, Nigi A, Nishimura K, Komada H, Tsurudome M, Yasutomi Y, Nosaka T, Mizutani H. Intranasally administered antigen 85B gene vaccine in non-replicating human parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis. PLoS One 2013 Jul 3; 8(7): e66614.

Shimozawa N, Ono R, Shimada M, Shibata H, Takahashi I, Inada H, Takada T, Nosaka T, Yasutomi Y. Cynomolgus monkey induced pluripotent stem cells established by using exogenous genes derived from the same monkey species. Differentiation 85: 131-139, 2013.　

Nagai Y, Iwade Y, Hayakawa E, Nakano M, Sakai T, Mitarai S, Katayama M, Nosaka T, Yamaguchi T. High resolution melting curve assay for rapid detection of drug-resistant Mycobacterium tuberculosis. J Infect Chemother 19: 1116-1125, 2013.

Watanabe K, Matsubara A, Kawano M, Mizuno S, Okamura T, Tsujimura Y, Inada H, Nosaka T, Matsuo K, Yasutomi Y. Recombinant Ag85B vaccine by taking advantage of characteristics of human parainfluenza type 2 virus vector showed Mycobacteria-specific immune responses by intranasal immunization. Vaccine 32: 1727-1735, 2014.

Kitamura T, Okochi-Watanabe N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y, Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S, Fukuyama T, Tanaka Y, Ono R, Goyama S, Nosaka T, Kitaura J, Inoue D. Novel working hypothesis for pathogenesis of hematological malignancies; Combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). J Biochem 159: 17-25, 2016.

Kobayashi K, Yamaguchi M, Miyazaki K, Imai H, Yokoe K, Ono R, Nosaka T, Katayama N. Expressions of SH3BP5, LMO3, and SNAP25 in diffuse large B-cell lymphoma cells and their association with clinical features. Cancer Med 5: 1802-1809, 2016.

Yamanaka K, Nakanishi T, Isono K, Hasegawa C, Inada Y, Mizutani K, Matsushima Y, Okada K, Mabuchi T, Kondo M, Yamagiwa A, Kakeda M, Habe K, Nosaka T, Gabazza EC, Yamazaki H, Mizutani H, Kawano M.　Restrictive interleukin-10 induction by an innocuous Parainfluenza virus vector ameliorates nasal allergy. J Allergy Clin Immunol 139: 682-686.e7, 2017.　

Nagatake T, Suzuki H, Hirata S, Matsumoto N, Wada Y, Morimoto S, Nasu A, Shimojou M, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii KJ, Nosaka T, Yasutomi Y, Kunisawa J. Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice. Int Immunol 30: 471-481, 2018.

Sawaki A, Miyazaki K, Yamaguchi M, Takeuchi T, Kobayashi K, Imai H, Tawara I, Ono R, Nosaka T, Katayama N. Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy. Int J Hematol 111: 686-691, 2020.

Book Chapters and Review Articles

Kita K, Miwa H, Nosaka T, Ohno T, Nasu K, Nanba K, Shirakawa S. Molecular genetic analysis of lymphoid malignancies. In: Hanaoka M et al., eds. Lymphoid Malignancy, Immunocytology and Cytogenetics. New York: Field & Wood Med Pub Inc. pp3-13, 1990.

Onishi M, Nosaka T, Kitamura T. Cytokine Receptors: Structure and signal transduction. Int Rev Immunol 16: 617-634, 1998.

Nosaka T, Onishi M, Kawashima T, Yamada K, Misawa K, Ariyoshi K, Towatari M, Saito H, Tani K, Asano S, Miyajima A, Kitamura T. Identification and characterization of constitutively active STAT5. In: Abraham NG et al., eds. Molecular Biology of Hematopoiesis 6. New York: Kluwer Academic/Plenum Publishers. pp277-287, 1999.

Nosaka T, Kitamura T. Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) in hematopoietic cells. Int J Hematol 71: 309-319, 2000.

Kitamura T, Kawashima T, Minoshima Y, Tonozuka Y, Hirose K, Nosaka T. Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation. Cell Struct Funct 26: 645-651, 2001.

Nosaka T. Jaks and normal hematopoiesis. In: Ward AC ed. The Jak-Stat Pathway in Hematopoiesis and Disease. Georgetown: Landes Bioscience Publishers (Eurekah. com., Austin) pp1-9, 2002.

Ono R, Nosaka T, Hayashi Y. Roles of a trithorax group gene, MLL, in hematopoiesis. Int J Hematol 81: 288-293, 2005.

邦文論文

宇野伸郎、野阪哲哉、内山哲、川上恵基、星野賢一郎、森美貴、堀田安則、太田千鶴子、小林透、北堅吉、白川茂.　造血器悪性疾患に合併した重症感染症に対する Amikacin と Cefoxitin の併用療法.　Jpn J Antibiotics 40(3): 469-475, 1987.

三輪啓志、松岡信良、野阪哲哉、北堅吉、白川茂.　悪性リンパ腫診断における分子遺伝学的手法の有用性と限界.　日本網内系学会会誌　29(2): 127-135, 1989.

野阪哲哉. 悪性リンパ腫の病因：ウイルス.　Pharma Medica 11(2): 15-19, 1993.

野阪哲哉. アンチセンス、env、腫瘍壊死因子、DNA修飾酵素、リンフォトキシン. In: 永田和宏、長野敬、宮坂信之、宮坂昌之　編集. 分子生物学・免疫学キーワード辞典東京医学書院　pp27-28, 100, 231-232, 296, 482. 1994.

宮崎之男、野阪哲哉、畑中正一. 第3章蛍光顕微鏡モードによる応用、4. 細胞内構造の観察への応用、 5) 核小体とウイルス. In: 石川春律、高松哲郎　編集. 新しい光学顕微鏡　第二巻　共焦点レーザ顕微鏡の医学・生物学への応用東京学際企画 pp111-115, 1995.

野阪哲哉.　JAK3 欠損マウスとリンパ球. 血液・腫瘍科 34(1): 48-55, 1997.

野阪哲哉. JAK3 と SCID. 医学のあゆみ 180(13): 842-845, 1997.　

野阪哲哉、北村俊雄. STAT 遺伝子の変異と機能変化. 血液・腫瘍科 40(6): 541-550, 2000.

野阪哲哉、北村俊雄. 造血疾患と転写因子. 組織培養工学　特集　転写因子の新しい展開 26(13): 503-506, 2000.

野阪哲哉. アダプター蛋白、アンチセンスRNA、アンチセンス鎖、アンチセンスDNA、アンチセンス法、修飾（DNAの）、DNAグリコシラーゼ. In: 伊藤正男、井村裕夫、高久史磨　編集. 医学大辞典　東京　医学書院 pp28, 81, 1111, 1682. 2003.

野阪哲哉. アンチセンス、env、Grb2、JNK/p38カスケード、Sos (son of sevenless)、DNA修飾酵素、DNAリガーゼ. In: 永田和宏、宮坂昌之、宮坂信之、山本一彦編集. 分子生物学・免疫学キーワード辞典第2版東京　医学書院　pp57-58, 206, 285, 417-418, 516, 555-556, 563. 2003.

野阪哲哉. プロテアーゼと白血病発症の意外な関係. In: News & Hot Paper Digest. 実験医学 22(1): 43-44, 2004.

北村俊雄、野阪哲哉. 新規チロシンキナーゼ阻害剤GTP14564とFlt3. マクロファージフォーラム Mini-review In: 今日の移植. 17(3): 416-420, 2004.

北村俊雄、熊谷英敏、野阪哲哉. Flt3阻害剤. In: 血液病の分子標的療法〜新たな展開〜. 血液フロンティア. 14(7): 47-53(1035-1041), 2004.

小埜良一、野阪哲哉. MLL関連白血病の分子病態. 血液・腫瘍科 52(6): 615-624, 2006.

野阪哲哉.　造血器腫瘍マウスモデル. がん分子標的治療.6(2):25-33(101-109), 2008.

野阪哲哉、小埜良一. MLL融合遺伝子による白血病発症機構. 血液・腫瘍科. 61(2): 217-223, 2010.

野阪哲哉.血液腫瘍モデル動物の現状と展望. In: 金倉譲編集. 造血器腫瘍学-基礎と臨床の最新研究動向- 日本臨床 2012年4月増刊（70 Suppl 2） pp159-164.

野阪哲哉. Jak-STAT経路. In: 細胞シグナル操作法. 生体の科学　66(5): 420-421, 2015.

福村正之, 大塚順平, 野阪哲哉. 有効なワクチンのない感染症に対してstructure-based designに基づいた新規ワクチンの開発. In: バイオベンチャー企業の新展開.Journal of Biological Macromolecules 18(2): 42, 2018.

小埜良一、野阪哲哉.血液腫瘍モデル動物の現状と展望. In: 金倉譲編集. 造血器腫瘍学（第2版）-基礎と臨床の最新研究動向-. II. 造血器腫瘍の基礎日本臨床 78巻　増刊号3 (2020年8月31日発行) pp152-158.