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三重大学教員紹介

教員情報

職名
准教授
氏名
こばやし てつ
小林 哲
生年月
 
所属
部局
附属病院
学科・専攻
内科系診療科
講座
呼吸器内科
教育研究分野
 
TEL
 
FAX
 
E-mail
 
個人のホームページ
 
学歴
三重大学医学部 学士課程 (~1991年)
三重大学医学部大学院 博士課程・博士後期課程 (~1999年)
学位
2000.07 医学博士 三重大学
所属学会
日本内科学会総合内科専門医
日本呼吸器学会指導医
日本呼吸器内視鏡学会指導医
日本アレルギー学会指導医
がん治療認定医機構暫定教育医
日本結核病学会結核・抗酸菌症指導医
日本医師会認定産業医
インフェクションコントロールドクター(ICD)

日本学術振興会 科学研究費委員会専門委員(2012/12/1~2014/11/30)
米国胸部学会誌(ATS) Editorial board (2015~)
社会活動
 
職歴
1991 三重大学医学部附属病院第3内科
1992~ 国立津病院内科,公立紀南病院内科,岡波総合病院内科,松阪市民病院内科,三重大学医学部附属病院
2000~2005 米国University of Nebraska Medical Center呼吸器内科部門
2006~ 三重大学医学部附属病院呼吸器内科
2015/4~    同  診療科長
2015/12~   同  病院教授
学術(芸術)賞
第19回臨床喘息研究会学術講演会 優秀演題賞(2011/11/19大阪)
第84回閉塞性肺疾患研究会 優秀演題賞(2012/1/28東京)
第85回閉塞性肺疾患研究会 優秀演題賞(2012/7/21東京)
第20回臨床喘息研究会学術講演会 優秀演題賞(2012/10/6金沢)
平成27年度公益信託岡本敏記念肺線維症研究基金受賞(2015/8/22東京)
専門分野
呼吸器内科学
現在の研究課題
RNAiを用いた創薬
Drug repositioningの研究
呼吸器疾患におけるmicrobiomeの研究
組織リモデリングの制御
肺癌発生の制御
抗がん剤耐性機構の制御
担当科目
呼吸機能検査
呼吸器感染症
身体所見の取り方
主な業績等
Sequential Use of ALK Inhibitors: An Optional Approach.
J Thorac Oncol. 2016Dec;11(12):e153-e154.

Efficacy of crizotinib in ALK fusion variants.
J Thorac Dis. 2016 Oct;8(10):E1381-E1383.

Pseudoprogression of Pulmonary Pleomorphic Carcinoma during
Nivolumab Therapy.
J Thorac Oncol. 2016 Oct;11(10):e117-9.

Protein S is protective in pulmonary fibrosis.
J Thromb Haemost. 2016 Aug;14(8):1588-99.

Activated protein C modulates the proinflammatory activity of dendritic cells.
J Asthma Allergy. 2015 May 7;8:29-37.

Matrix metalloproteinase-9 activates TGF-ß1 and stimulates fibroblast contraction of collagen gels.
Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1006-15.

Thrombin-Activatable Fibrinolysis Inhibitor Protects Against Acute Lung Injury by Inhibiting the Complement System.
Am J Respir Cell Mol Biol. 2013 Oct;49(4):646-53.

Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells.
PLoS One. 2013;8(5):e64281.

Efficacy of a novel class of RNA interference therapeutic agents.
PLoS One. 2012;7(8):e42655.

Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis.
Am J Respir Cell Mol Biol. 2012 Mar;46(3):397-406.

Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.
Am J Respir Crit Care Med. 2011;183(1):31-42.

Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents: double blind, randomised and placebo controlled trial.
BMJ. 2010 Mar 8;340:c1004.

PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts.
Am J Physiol Lung Cell Mol Physiol. 2009;296(6):L959-69.

NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract.
Respir Res. 2008;9:66.

A prospective comparison of nursing home-acquired pneumonia with
hospital-acquired pneumonia in non-intubated elderly.
Respir Med. 2008;102(9):1287-95.

Prostacyclin analogs stimulate VEGF production from human lung fibroblasts in culture.
Am J Physiol Lung Cell Mol Physiol. 2008;294(6):L1226-32.
.
Role of thrombin in interleukin-5 expression from basophils.
Biochem Biophys Res Commun. 2008;368(1):116-20.

Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor.
Am J Respir Cell Mol Biol. 2008;39(3):356-63.

PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel
contraction.
Biochem Biophys Res Commun. 2008;369(4):1199-203.

The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6.
Am J Respir Cell Mol Biol. 2007;37(1):121-8.

Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway.
Am J Respir Cell Mol Biol. 2007;37(1):113-20.

Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradation.
Am J Respir Cell Mol Biol. 2006;35(6):714-21.

Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure.
Proc Natl Acad Sci U S A. 2006;103(24):9250-5.

Reactive nitrogen species augment fibroblast-mediated collagen gel contraction, mediator production, and chemotaxis.
Am J Respir Cell Mol Biol. 2006;34(5):592-9.

Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung
fibroblasts.
Biochem Biophys Res Commun. 2006;339(1):290-5.

TGF-beta1 and serum both stimulate contraction but differentially affect
apoptosis in 3D collagen gels.
Respir Res. 2005 Dec 2;6:141.

Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells.
Am J Respir Cell Mol Biol. 2005 Aug;33(2):121-9.

Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts.
Biochem Biophys Res Commun. 2005 Feb 11;327(2):393-8.

Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon.
Eur Respir J. 2004 Dec;24(6):918-24.

Cells derived from the circulation contribute to the repair of lung injury.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1158-63.

Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts.
Am J Respir Cell Mol Biol. 2004 Nov;31(5):483-90.

Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
Am J Respir Cell Mol Biol. 2004 Jun;30(6):816-22.

TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids.
J Allergy Clin Immunol. 2003 Jun;111(6):1307-18.

Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction.
Am J Respir Cell Mol Biol. 2003 Jan;28(1):111-21.

Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase.
Am J Respir Cell Mol Biol. 2002 Oct;27(4):487-94.

PGD(2) modulates fibroblast-mediated native collagen gel contraction.
Am J Respir Cell Mol Biol. 2002 Sep;27(3):375-81.

Prostacyclin analogs inhibit fibroblast migration.
Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L428-32.

Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke.
Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L409-17.

Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma.
Am J Respir Cell Mol Biol. 2002 Apr;26(4):484-90.

Long-term inhalation of high-dose nitric oxide increases intraalveolar activation of coagulation system in mice.
Am J Respir Crit Care Med. 2001 Jun;163(7):1676-82.

Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse.
Am J Respir Crit Care Med. 2001 Jun;163(7):1660-8.

Type I collagen metabolites as tumor markers in patients with lung carcinoma.
Cancer. 1999 May 1;85(9):1951-7.

Protein C anticoagulant system in patients with interstitial lung disease.
Am J Respir Crit Care Med. 1998 Jun;157:1850-4.

Arterial endothelin-1 level in pulmonary emphysema and interstitial lung disease. Relation with pulmonary hypertension during exercise.
Eur Respir J. 1997 Sep;10(9):2055-60.

The effect of low-dose inhalation of nitric oxide in patients with pulmonary
fibrosis.
Eur Respir J. 1997 Sep;10(9):2051-4.

Prognostic significance of plasma D-dimer levels in patients with lung cancer.
Thorax. 1997 Jun;52(6):563-5.

Combined inhalation of nitric oxide and oxygen in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med. 1997 Feb;155(2):526-9.


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