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三重大学教員紹介

教員情報

職名
准教授
氏名

藤原 武志
生年月
1969
所属
部局
医学系研究科
学科・専攻
生命医科学専攻
講座
基礎医学系講座
教育研究分野
 
TEL
 
FAX
 
E-mail
ts-fujiwara@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
 
学歴
大阪大学理学部 学士課程 卒業
大阪大学大学院理学研究科 博士前期課程 修了
大阪大学大学院医学系研究科 博士課程 修了
学位
1999.03 博士(医学) 大阪大学
1995.03 修士(理学) 大阪大学
所属学会
米国細胞生物学会 日本神経科学学会 日本生理学会
社会活動
 
職歴
1996.04~1999.03 日本学術振興会(大阪大学大学院医学系研究科)  特別研究員(DC1) 
1999.04~1999.09 戦略的創造研究推進事業(高井生体時系プロジェクト)  博士研究員 
1999.10~2002.04 バンダービルト大学医学部(米国) 博士研究員 
2002.05~2005.03 ダナ・ファーバー癌研究所、ハーバード大学医学校(米国) 博士研究員 
2005.04~2008.12 株式会社 カン研究所 主幹研究員
2009.01~2013.03 大阪大学大学院医学系研究科 生化学・分子生物学講座 生化学分野  特任准教授(常勤)
2013.04~ 大阪大学大学院生命機能研究科 招へい准教授
2013.04~2013.07 学校法人・専門学校 大阪医専 非常勤講師
2015.04~2015.09 三重県立看護大学 非常勤講師
学術(芸術)賞
 
専門分野
分子生物学、細胞生物学、免疫組織化学、分子神経科学
現在の研究課題
中枢神経回路の形成機構
担当科目
組織学総論 組織学各論 分子医科学(分担) チュートリアル教育(分担)
主な業績等
Roles of afadin in the formation of the cellular architecture of the mouse hippocampus and dentate gyrus. 共著 2016.12 Molecular and Cellular Neuroscience 79, 34-44.

Localization of Nectin-2delta at Perivascular Astrocytic Endfoot Processes and Degeneration of Astrocytes and Neurons in Nectin-2 Knockout Mouse Brain. 共著 2016.10 Brain Research 1649(Pt A), 90-101.

Cooperative Roles of Nectins with Cadherins in Physiological and Pathological Processes. The cadherin superfamily: key regulators of animal development and physiology. 共著 2016 Springer Japan. pp115-156.

Dynamic change of polarity in primary cultured spheroids of human colorectal adenocarcinoma and its role in metastasis. 共著 2016.04 American Journal of Pathology 186(4), 899-911.

Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus. 共著 2016.01 Genes to Cells 21(1) 88-98.

Real-time histological imaging of kidneys stained with food dyes using multiphoton microscopy. 共著 2015.10 Microsc. Res. Tech. 78 (10) 847-858.

Nectin-1 Spots Regulate the Branching of Olfactory Mitral Cell Dendrites. 共著 2015.07 Mol. Cell. Neurosci. 68 143-150.

Nectin-1 Spots as a Novel Adhesion Apparatus that Tethers Mitral Cell Lateral Dendrites in a Dendritic Meshwork Structure of the Developing Mouse Olfactory Bulb. 共著 2015.08 J. Comp. Neurol. 523 (12) 1824-1839.

Development of bis-unsaturated ester aldehydes as amino-glue probes: Sequential double azaelectrocyclization as promising strategy for bioconjugation. 共著 2013.10 Organic & Biomolecular Chemistry 11 (42) 7326-7333.

A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration. 共著 2013.10 Biochemical and Biophysical Research Communications 440 (3) 359-363.

Inhibition of p53 transactivation functionally interacts with microtubule stabilization to suppress excitotoxicity-induced axon degeneration. 共著 2012.10 Biochemical and Biophysical Research Communications 427 (1) 100-106.

Cooperative effect of p150Glued and microtubule stabilization to suppress excitotoxicity-induced axon degeneration. 共著 2012.07 Biochemical and Biophysical Research Communications 424 (1) 82-88.

Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity. 共著 2012.07 Journal of Neurochemistry 122 (1) 162-174.

Cell surface biotinylation by azaelectrocyclization: easy-handling and versatile approach for living cell labeling. 共著 2012.03 Bioorganic & Medicinal Chemistry 20 (6) 1865-1868.

Hyaluronan–CD44 pathway regulates orientation of mitotic spindle in normal epithelial cells. 共著 2008.07 Genes to Cells 13 (7) 759-770.

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. 共著 2005.10 Nature 437 (7061) 1043-1047.

Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 共著 2002.10 Development 129 (20) 4685-4696.

Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 共著 2001.11 Proceedings of the National Academy of Sciences of the United States of America 98 (24) 13739-13744.

Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiae. 共著 2001.02 Molecular and Cellular Biology 21 (3) 827-839.

Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. 共著 2000.05 Biochemical and Biophysical Research Communications 271 (3) 626-629.

Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. 共著 1999.12 Molecular and Cellular Biology 19 (12) 8016-8027.

An FH domain-containing Bnr1p is multifunctional protein interacting with a variety of cytoskeletal proteins in Saccharomyces cerevisiae. 共著 1999.11 Oncogene 18 (50) 7046-7054.

Shs1p: A novel member of Septin that interacts with Spa2p, involved in polarized growth in Saccharomyces cerevisiae. 共著 1998.10 Biochemical and Biophysical Research Communications 251 (3) 732-736.

Rho1p-Bni1p-Spa2p interactions: Implication in localization of Bni1p at the bud site and regulation of the actin cytoskeleton in Saccharomyces cerevisiae. 共著 1998.05 Molecular Biology of the Cell 9 (5) 1221-1233.

Membrane localization, topology, and mutual stabilization of the rnfABC gene products in Rhodobacter capsulatus and implications for a new family of energy-coupling NADH Oxidoreductases. 共著 1997.05 Biochemistry 36 (18) 5509-5521.

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP-binding protein in Saccharomyces cerevisiae. 共著 1996.11 EMBO Journal 15 (22) 6060-6068.

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. 共著 1995.12 EMBO Journal 14 (23) 5931-5938.

Nucleotide sequence and genetic analysis of the region essential for functional expression of the gene for Ferredoxin I, fdxN, in Rhodobacter capsulatus: Sharing of one upstream activator sequence in opposite directions by two operons related to nitrogen fixation. 共著 1995.03 Plant and Cell Physiology 34 (2) 185-199.

低分子量G蛋白質と細胞の接着・運動 共著 1999.09 Biotherapy 13 (9) 909-921


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