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三重大学教員紹介

教員情報

職名
准教授
氏名
パク ウンゾン
朴 恩正
生年月
1967.11
所属
部局
医学系研究科
学科・専攻
生命医科学専攻
講座
基礎医学系講座
教育研究分野
 
TEL
059-231-6408
FAX
059-231-5209
E-mail
epark@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
 
学歴
1993 成均館大学校卒業 (学士)
1995 同大学校大学院卒業 (修士)
学位
2004 大阪大学 (医学博士)
所属学会
国際粘膜免疫学会
日本免疫学会
社会活動
Institutional Animal Care and Use Committee at Immune Disease Institute, Harvard Medical School (2009)
Blood Journal ad hoc reviewer (2010)
職歴
1994-1999 財団法人牧岩生命工学研究所 主任研究員
2004-2009 ハーバード大学医学部 博士研究員
2009-2011 ハーバード大学医学部 Instructor
2011-2012 東京大学医科学研究所 研究員
2012-2014 東京大学医科学研究所 特任助教
2014.10- 三重大学医学系研究科 准教授
学術(芸術)賞
2008 GSK-IDI Postdoctoral Fellowship Award
2013 (財)飯島記念食品科学振興財団学術研究助成
専門分野
粘膜免疫学
細胞接着・動態
分子病態学
現在の研究課題
老化における細胞動態機構の解明


担当科目
分子病態学
主な業績等
(original articles)
Fukuyama Y, Yuki Y, Katakai Y, Harada N, Takahashi H, Takeda S, Mejima M, Joo S, Kurokawa S, Sawada S, Shibata H, Park EJ, Fujihashi K, Briles DE, Yasutomi Y, Tsukada H, Akiyoshi K, Kiyono H. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunol. 2015 Feb 11

Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J. Biotechnol. 2014, 175:45-52

Dearling JL, Park EJ, Dunning P, Baker A, Fahey F, Treves ST, Soriano SG, Shimaoka M, Packard AB, Peer D. Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm. Bowel Dis. 2010, 16:1458-66

Park EJ, Peixoto A, Imai Y, Goodarzi A, Cheng G, Carman CV, von Andrian UH, Shimaoka M. Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood 2010, 115:1572-81

Imai Y, Park EJ, Peer D, Peixoto A, Cheng G, von Andrian UH, Carman CV, Shimaoka M. Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins. Blood 2008, 112:5007-15

Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 2008, 319:627-30

Park EJ, Mora JR, Carman CV, Chen J, Sasaki Y, Cheng G, von Andrian UH, Shimaoka M. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J. Clin. Invest. 2007, 117:2526-38

Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H. Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J. Immunol. 2006, 177:4276-80.

Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, Kiyono H. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J. Immunol. 2005, 174:4365-72

Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J. Immunol. 2004, 173:3337-47

Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki JI, Kiyono H. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J. Immunol. 2003, 171:4131-39

Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, Kiyono H. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J. Immunol. 2002, 169:6187-92

Kim JS, Chang JH, Park EJ, Chung SI, Yum JS. Evaluation of factors that can affect protective immune responses following oral immunization of recombinant Helicobacter pylori urease apoenzyme. J. Microbiol. Biotechnol. 2000, 10:865-872

Park EJ, Chang JH, Kim JS, Yum JS, Chung SI. The mucosal adjuvanticity of two nontoxic mutants of Escherichia coli heat-labile enterotoxin varies with immunization routes. Exp. Mol. Med. 2000, 32:72-8

Park EJ, Chang JH, Kim JS, Chung SI, Yum JS. Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin. Exp. Mol. Med. 1999, 31:101-7

Won J, Kim H, Park EJ, Hong Y, Kim SJ, Yun Y. Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy. Cancer Res. 1999, 59:1273-7

Kim JH, Park EJ, Lee TK, Lee WS. Genomic sequences of the soybean 24 kDa oleosin genes and initial analysis of their promoter sequences. Mol. Cells 1996, 6:393-399

(review articles, book chapters, patents)
Park EJ, Shimaoka M. Activation of Leukocyte Integrins. Curr. Top. Membr. Leukocyte Adhesion 64, 2009, 4:115-32

Shimaoka M, Park EJ. Advances in understanding sepsis. Eur J Anaesthesiol 2008, 42:146-53

高橋 一郎、朴 恩正、清野 宏. 粘膜免疫担当組織細胞の特殊性と炎症性腸疾患. Molecular Medicine, 2002, 39:1000-1007

Park EJ, Kim JS, Chang J, Yum JS, Chung SI. Detoxified mutants of Escherichia coli heat-labile enterotoxin. 2010, US7722887B1

Chang J, Kim JS, Park EJ, Yum JS, Chung SI. Nucleic Acid Encoding Angiogenesis inhibitor. 2006, US7118905B2

Chang J, Kim JS, Park EJ, Yum JS, Chung SI. Angiogenesis Inhibitor. 2004, US6743428B1


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