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三重大学教員紹介

教員情報

職名
准教授
氏名
おおいしこうし
大石晃嗣
生年月
1961.05
所属
部局
附属病院
学科・専攻
輸血・細胞治療部
講座
 
教育研究分野
 
TEL
 
FAX
 
E-mail
koishi@clin.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
 
学歴
金沢大学医学部 学士課程 (~1988年)
博士課程・博士後期課程 (~)
学位
1996.03 医学博士 三重大学
所属学会
内科学会
社会活動
 
職歴
1988.06~1989.08 三重大学医学部附属病院 医員・研修医
1989.09~1991.08 厚生連松阪中央総合病院内科 研修医
1991.09~1998.03 三重大学医学部附属病院 医員
1998.04~2002.04 Fred Hutchinson 癌センター Research associate
2002.05~2002.09 三重大学医学部附属病院 医員
2002.11~2006.10 宮川医療少年院 医務課長
2007.04~2007.10 三重大学医学部附属病院輸血部 助教
2007.11~ 三重大学医学部附属病院輸血部 部長 講師
2013.9~2017.3 三重大学医学部附属病院輸血部准教授
2017.4~ 三重大学医学部附属病院輸血部病院教授
学術(芸術)賞
 
専門分野
 
現在の研究課題
リンパ球分化と腫瘍化のメカニズムの解明
担当科目
骨髄増殖性腫瘍、貧血、輸血、HIV
主な業績等
1. Ohishi K, Katayama N, Itoh R, Mahmud N, Miwa H, Kita K, Minami N, Shirakawa S, Lyman SD, Shiku H. Accelerated cell-cycling of hematopoietic progenitors by the flt3 ligand that is modulated by transforming growth factor-. Blood 87:1718-27, 1996.
2. Ohishi K, Varnum-Finney B, Flowers D, Anasetti C, Myerson D, Bernstein ID. Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1. Blood 95:2847-2854, 2000.
3. Ohishi K, Varnum-Finney B, Serda R.E, Anasetti C, Bernstein ID. The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells. Blood 98:1402-1407, 2001.
4. Ohishi K, Katayama N, Mitani H, Araki H, Masuya M, Suzuki H, Hoshino N, Miyashita H, Nishii K, Kageyama S, Minami N, Shiku H. Efficient ex vivo generation of human dendritic cells from mobilized CD34+ peripheral blood progenitors. Int J Hematol 74:287-296, 2001.
5. Ohishi K, Varnum-Finney B, Bernstein I.D. Delta-1 enhances marrow and thymic repopulating ability of human CD34+CD38- cord blood cells. J Clin Invest 110:1165–1174, 2002.
6. Sakakura M, Ohishi K**, Nomura K, Katayama N, Nishii K, Masuya M, Nakase K, Shiku H. A Case of Chronic-Phase Chronic Myelogenous Leukemia With an Abdominal Hematopoietic Tumor of Leukemic Clone Origin. Am J Hematol 77:167-170, 2004.
7. Hoshino N, Katayama N, Shibasaki T, Ohishi K, Nishioka J, Masuya M, Miyahara Y, Hayashida M, Shimomura D, Kato T, Nakatani K, Nishii K, Kuribayashi K, Nobori T, Shiku H. A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes J Leukoc Biol 78(4):921-929, 2005.
8. Yamamura K, Ohishi K*,**, Katayama N, Yu Z, Kato K, Masuya M, Fujieda A, Sugimoto Y, Miyata E, Shibasaki T, Heike Y, Takaue Y, Shiku H. Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis. Br J Haematol 135: 242-253, 2006.
9. Suzuki K, Ohishi K**, Sekine T, Katayama N. Selective Blast Cell Reduction in Elderly Patients with Acute Myeloid Leukemia Secondary to Myelodysplastic Syndrome Treated with Methylprednisolone. Int J Hematol 85:344-9, 2007.
10. Yamamura K, Ohishi K*,**, Katayama N, Kato K, Shibasaki T, Sugimoto Y, Miyata E, Shiku H, Masuya M, Nishioka J, Nobori T, Nishikawa M, Inagaki Y, Hiramatsu H, Nakahata T. Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptor -positive and -negative human hematopoietic progenitors. Cancer Sci 98:1597-1603, 2007.
11. Yamamura K, Ohishi K**, Masuya M, Miyata E, Sugimoto Y, Nakamura S, Fujieda A, Araki H, Katayama N. Ex Vivo Culture of Human Cord Blood Hematopoietic Stem/Progenitor Cells Adversely Influences Their Distribution to Other Bone Marrow Compartments after Intra-bone Marrow Transplantation. Stem cells. 26:543-549, 2008. Ito-Habe N, Wada H, Matsumoto T, Ohishi K, Toyoda H, Ishikawa E, Nomura S, Komada Y, Ito M, Nobori T, Katayama N. Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome. Int H Hematol 93(1):47-52, 2010.
12. Tanaka Y, Ohishi K**, Yonekawa T, Yodoya N, Iwamoto S, Nishioka Y, Tatara Y, Matsumoto T, Masuya M. Effect of washing solution on platelet counts following transfusion with twice-washed platelets: a single-patient experience. Transfus Med. 20(5):358-360, 2010.
13. Nakamura A, Sugimoto Y, Ohishi K**, Sugawara Y, Fujieda A, Monma F, Suzuki K, Masuya M, Nakase K, Matsushima Y, Wada H, Katayama N, Nobori T. Diagnostic value of PCR analysis of bacteria and fungi from blood in empiric-therapy-resistant febrile neutropenia. J Clin Microbiol. 48(6):2030-2036, 2010.
14. Liu B, Ohishi K**, Yamamura K, Suzuki K, Monma F, Ino K, Nishii K, Masuya M, Sekine T, Heike Y, Takaue Y, Katayama N. A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis. Exp Hematol 38(8):685-695, 2010. Ito-Habe N, Wada H, Matsumoto T, Ohishi K, Toyoda H, Ishikawa E, Nomura S, Komada Y, Ito M, Nobori T, Katayama N. Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome. Int J Hematol. 93(1):47-52, 2011.
15. Suzuki K, Ono R,Ohishi K, Masuya M, Kataoka I, Liu B, Nakamori Y, Ino K, Monma F, Hamada H, Kitamura T, Katayama N, Nosaka T. IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells. Suzuki K, Ono R, Ohishi K. Int J Oncol 40(1):53-62, 2012.
16. Nakamori Y, Liu B, Ohishi K**, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N. Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis. Br J Haematol 157(6):674-686, 2012.
17. Liu B, Ohishi K**, Orito Y, Nakamori Y, Nishikawa H, Ino K, Suzuki K, Matsumoto T, Masuya M, Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N. Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy. Exp Hematol 41(4):367-376, 2013.
18. Sugimoto Y, Sada A, Shimokariya Y, Monma F, Ohishi K, Masuya M, Nobori T, Matsui T, Katayama N. A novel FOXP1-PDGFRA fusion gene in myeloproliferative neoplasm with eosinophilia. Cancer Genet 208(10):508-12, 2015.
19. Nagaharu K, Sugimoto Y, Hoshi Y, Yamaguchi T, Ito R, Matsubayashi K, Kawakami K, Ohishi K. Persistent symptomatic parvovirus B19 infection with severe thrombocytopenia transmitted by red blood cell transfusion containing low parvovirus B19 DNA levels. Transfusion. 2017 Jun;57(6):1414-1418, 2017
20. Minami H, Nagaharu K, Nakamori Y, Ohishi K**, Shimojo N, Kageyama Y, Matsumoto T, Sugimoto Y, Tawara I, Masuya M, Miwa H, Katayama N.  CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation. J Immunol. 1;199(7):2343-2355, 2017





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