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三重大学教員紹介

教員情報

職名
准教授
氏名
いとう ともひろ
伊藤 智広
生年月
1975.11
所属
部局
生物資源学研究科
学科・専攻
生物圏生命科学専攻
講座
海洋生命分子化学
教育研究分野
 
TEL
059-231-9675
FAX
059-231-9675
E-mail
titoh@bio. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ
学歴
 
学位
2005.09 博士(学術) 三重大学
所属学会
日本農芸化学会 日本栄養・食糧学会 日本薬学会 日本食品科学工学会 日本骨代謝学会 日本水産学会 日本分子生物学会 日本香粧品学会 日本食品化学会
社会活動
近畿大学,農学部 水産学科
職歴
1998.04~2006.03 井村屋製菓株式会社 中央研究所 研究員
2006.04~2011.03 財団法人岐阜県研究開発財団岐阜県国際バイオ研究所 健康有用物質研究部 専任研究員
2011.04~2015.03 学校法人 近畿大学 農学部 水産学科 講師
2015.04~2016.03 学校法人 近畿大学 農学部 水産学科 准教授
学術(芸術)賞
日本水産学会 奨励賞,藍藻類イシクラゲをはじめとする天然物に含まれる機能性成分に関する研究,2015.03,公益社団法人 日本水産学会
専門分野
食品機能学,生化学
現在の研究課題
天然動植物や食品加工残渣に含まれる低分子化合物の機能性探索,骨代謝におけるexosomeの役割,皮膚常在菌の膜小胞と皮膚細胞とのコミュニケーション機構,アンチエイジング海産物の開発,血管石灰化モデル動物の作製(ゼブラフィッシュモデル)
担当科目
化学実験 水圏生物利用学特論
主な業績等
Sentulic acid isolated from Sandoricum koetjape Merr attenuates lipopolysaccharide and interferon gamma co-stimulated nitric oxide production in murine macrophage RAW264 cells. 共著 2018.10. Bioorganic & Medicinal Chemistry Letters 28,2496-3501.

Phytol isolated from watermelon (Citrullus lanatus) sprouts induces cell death in human T-lymphoid cell line Jurkat cells via S-phase cell cycle arrest. 共著 2018.03. Food and Chemical Toxicology 115, 425-435.

OM-X®, a fermented vegetables extract, facilitates muscle endurance capacity in swimming exercise mice. 共著 2017.01 Natural Product Communications 12 111-114
冷凍カツオ肉の肉色保持技術に関する研究 共著 2018.01 日本水産学会誌 84 111-118.

Inhibitory effects of echinochrome A, isolated from shell of sea urchin Anthocidaris crassispina on antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells through the suppressing of Lyn activation. 共著 2016.09 Natural Products Communications 11 1303-1306 .

OM-X®, fermented vegetables extract suppresses antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous 共著 2015.09 Natural Products Communications 10 1597-1601 .

Muscle growth in full-cycle cultured Pacific bluefin tuna Thunnus orientalis from early larval to juvenile stage: histochemical, immunohistochemical and ultrastructural observation. 共著 2014.07 Fisheries Science 80 1009-1020.

Effects of additional cysteine in fish diet on mercury concentration. 共著 2014.03 Food Chemistry 147 340-345.

A synthesized nostocionone derivative potentiates programmed cell death in human T-cell leukemia Jurkat cells through mitochondria via the release of endonuclease G. 共著 2014.10 Nutrition and Cancer 66 1414-1423.

Regulation of the differentiation of osteoblast and osteoclast by a hot-water extracts of adzuki beans (Vigna angularis) . 共著 2014.04 Bioscience, Biotechnology, and Biochemistry 78 92-99.

Reduced scytonemin isolated from Nostoc commune suppresses LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by inducing hemeoxygenase-1 expression via the Nrf2/ARE pathway 共著 2014.07 Food and Chemical Toxicology 69 330-338.

Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes. 共著 2014.06 Anaerobe 27 56-63.

Improvement of red color development on the surface of Kuruma Prawn Marsupenaeus japonicus under various conditions. 共著 2014.02 Journal of Food Science 79 E202-E207.

Novel method for improving the antioxidative properties of fish meat by direct injection of sodium L-ascorbate into the blood vessels of live fish. 共著 2013.03 Fisheries Science 79 349-355.

Reduced scytonemin isolated from Nostoc commune induces autophagic cell death in Human T-lymphoid cell line Jurkat cells. 共著 2013.10 Food and Chemical Toxicology 60 76-82.

ラット好塩基球細胞株RBL-2H3 細胞における抗原刺激後脱顆粒に及ぼすタツノオトシゴ(Hippocampus kelloggi Jordan)エタノール抽出物の抑制効果 共著 2013.07 日本水産学会誌 79 683-693.

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through inhibiting JNK activation and CD36 expression in HepG2 cells. 共著 2013.05 Medical Gas Research 3 1-7.

A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells. 共著 2013.05 Pharmacology Research 71 34-43.

Assessment of concentrations of toxic elements in aquaculture food products in Malaysia. 共著 2012.08 Food Chemistry 133 1326-1332.

Muscle fiber types, growth and development in the whole myotome of cultured Pacific bluefin tuna Thunnus orientalis. 共著 2012.03 Fisheris Science 78 471-483.

Application of supercooling to long-term storage of fish meat. 共著 2012.03 Fisheris Science 78 451-461.

Immunomodulatory effects of heat-killed Enterococcus faecalis TH10 on murine macrophage cells. 共著 2012.12 MicrobiologyOpen 1 373-380.

Whisky congeners suppress LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by the inducing hemeoxygenase-1 expression. 共著 2012.12 Journal of Agricultural Food Chemistry 60 12491-12500.

Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on LPS/IFNγ-stimulated nitric oxide production in RAW264 cells. 共著 2012.06 Biological & Pharmaceutical Bulletin 35 963-966.

Expressions of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370. 共著 2012.06 FEBS Letters 586 1693-1701 .

Microvesicles released from hormone-refractory prostate cancer cells facilitate mouse pre-osteoblast differentiation. 共著 2012.10 Journal of Molecular Histology 43 509-515.

Structural and ultrastructural changes of full-cycle cultured Pacific bluefin tuna (Thunnus orientalis) muscle slices during chilled storage. 共著 2012.06 Journal of the Science of Food and Agriculture 92 1755-1764.

Hot water extract of adzuki (Vigna angularis) suppresses antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. 共著 2012.07 Phytotherapy Research 26 1003-1011.

Inhibitory effects of flavonoid glycosides isolated from the peel of japanese persimmon (Fuyu-kaki) on antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells. 共著 2011.05 Food Chemistry 126 289-294.

Molecular hydrogen inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production through modulation of signal transduction in macrophages. 共著 2011.07 Biochemical and Biophysical Research Communications 411 143-149.

Cisplatin-induced reactive oxygen species production NADPH oxidase in human prostate cancer cell lines. 共著 2011.09 Free Radical Resarch 45 1033-1039.

Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds. 共著 2011.03 Bioorganic & Medicinal Chemistry19 19 1956-1965.

Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. 共著 2011.02 Molecular Therapy 19 395-399.

Role of microRNA-143 and -145 in human colorectal tumors. 共著 2010.06 Cancer Gene Therapey  17 398-408.

SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts. 共著 2010.04 British Journal of Dermatology 163 689-694.

Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells. 共著 2010.10 Bioorganic & Medicinal Chemistry  18 7001-7008.

Chalcone glycosides isolated from aerial parts of Brassica rapa L. ‘hidabeni’ suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells. 共著 2010.10 Bioorganic & Medicinal Chemistry  18 7052-7057.

Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation. 共著 2010.08 Bioorganic &Medicinal Chemistry 18 5932-5937.

MicroRNA-208 modulates BMP-2-stimulated mouse pre-osteoblast differentiation by direct targeting V-ets erythroblastosis virus E26 oncogene homolog 1. 共著 2010.09 The Journal of Biological Chemistry 285 27745-27752.

Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. 共著 2010.06 Journal of Agricultural Food Chemistry 58 7149-7157.

A novel kavalactone derivative protects against:H2O2-induced PC12 cell death via Nrf2/ARE activation. 共著 2010.05 Bioorganic & Medicinal Chemistry 18 3133-3139 .

Inhibitory effect of flavonoid glycosides isolated from the peel of japanese persimmon (Fuyu-kaki) on melanin biosynthesis. 共著 2010.01 Inhibitory effect of flavonoid glycosides isolated from the peel of japanese persimmon (Fuyu-kaki) on melanin biosynthesis. 33 122-124.

Molecular hydrogen attenuates degranulation of mast cells through suppression of FcεRI-mediated signal transduction. 共著 2009.11 Biochemical and Biophysical Research Communications  389 651-656.

Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3. 共著 2009.08 Bioorganic & Medicinal Chemistry  17 5374-5379.

Effects of teaflavins on melanin biosynthesis in mouse B16 melanoma cells. 共著 2009.06 Bioscience, Biotechnology, and Biochemistry 73 1429-1431.

MicroRNA-141 and -200a are involved in bonemorphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5. 共著 2009.07 The Journal of Biological Chemistry 284 19272-19279.

Intracellular glutathione regulates sesquiterpene lactone-induced conversion of autophagy to apoptosis in human leukemia HL60 cells. 共著 2009.04 Anticancer Research 29 1449-1458.

Inhibitory effects of sesquiterpene lactones isolated from eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. 共著 2009.04 Bioorganic & Medicinal Chemistry 17 3189-3197.

Lowering serum cholesterol level by feeding hot-water extract of adzuki beans torat fed with high-fat cholesterol diet. 共著 2009.03 Nutrition 25 318-321.

Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells. 共著 2009.02 Biological & Pharmaceutical Bulletin 32 308-310.

Hypoglycemic effect of a hot-water extract from adzuki beans (Vigna angularis)on the blood glucose level in genetically diabetic KK-Ay mice. 共著 2009.02 Nutrition 25 134-141.

Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. 共著 2008.08 Bioorganic & Medicinal Chemistry 16 7592-7598.

Inhibitory effects of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. 共著 2008.04 Bioorganic & Medicinal Chemistry 46 4500-4508.

Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. 共著 2008.05 Bioorganic & Medicinal Chemistry 16 2803-2810.

Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation. 共著 2008.04 Biochemical and Biophysical Research Communications 368 948-954.

Eupalinin A isolated from Eupatrium chinense L. induces autophagocytosis in humanleukemia HL60 cells. 共著 2008.01 Bioorganic & Medicinal Chemistry 16 721-731.

Peroxyl and hydroxyl radical scavenging activities of raw and processed sea urchins measured by chemiluminescence and electron spin resonance methods. 共著 2008.01 Journal of Clinical Biochemistry and Nutrition 43 567-570.

The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium. 共著 2007.01 Bioorganic & Medicinal Chemistry 15 3667-3671.

アズキ熱水抽出物(アズキ煮汁)中に含まれるヒト胃癌細胞に対するアポトーシス誘導物質の同定 共著 2005.05 日本栄養・食糧学会誌 58 281-287.

アズキ熱水抽出物から得た新規テルペノイド配糖体Vignoside 共著 2005.07 日本食品科学工学会誌  52 319-323.

Hot-water extracts from adzuki beans (Vigna angularis) stimulated not only melanogenesis in cultured mouse B16 melanoma cells but also pigmentation of hair color in C3H mouse. 共著 2005.05 Bioscience, Biotechnology and Biochemistry 69 873-882.

Potential ability of hot water adzuki (Vigna angularis) extracts to inhibit the adhesion, invasion and metastasis of murine B16 melanoma cells. 共著 2005.03 Bioscience, Biotechnology and Biochemistry 69 448-454.

Suppressive effect of hot water extract of adzuki beans (Vigna angularis) on hyperglycemia after sucrose loading in mice and diabetic rats. 共著 2004.12 Bioscience, Biotechnology, and Biochemistry 68 2421-2426.

Hot-water extracts from adzuki beans (Vigna angularis) suppress not only the proliferation of KATOⅢ cells in culture but also benzo(a)pyrene-induced tumorigenesis in mouse forestomach. 共著 2004.05 Journal of Nutritional Science and Vitaminology 50 295-299.

ヒト胃癌細胞におけるアズキ熱水抽出物(アズキ煮汁)によるアポトーシス誘導 共著 2002.05 日本食品科学工学会誌  49 339-344.

Role of non biological processes associated with sediment in purification of coastal seawater. 単著 1999.01 Fisheries Science 65 36-41.


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