職名 准教授
氏名 かさはら こうすけ
笠原 広介
生年月 1978.07
所属 部局 医学系研究科
学科・専攻 生命医科学専攻
講座 基礎医学系講座
教育研究分野 分子生理学
TEL  
FAX  
E-mail kkasahara@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ  
学歴 2001.3 千葉大学薬学部 卒業
2003.3 千葉大学大学院医学薬学府総合修士課程 修了
2006.3 千葉大学大学院医学薬学府博士課程 修了

学位 博士(医薬学)
所属学会 日本癌学会 、日本分子生物学会
社会活動  
職歴 2006.4〜2007.3 日本学術振興会特別研究員PD
2007.4〜2017.9 愛知県がんセンター研究所 研究員
2011.4〜2017.9 名古屋市立大学薬学部腫瘍生物学 客員准教授
2017.10~ 三重大学医学系研究科分子生理学 准教授
学術(芸術)賞 2011 NAGOYOグローバルCOEリサーチアワード
2018 日本癌学会奨励賞
専門分野 細胞生物学、分子生物学、病態医化学
現在の研究課題 一次シリアによる細胞増殖制御機構の解明
担当科目 生理学2、人体機能学
主な業績等 Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain. 2004.06 The Journal of cell biology 165 641-52
Involvement of Golgi-associated Lyn tyrosine kinase in the translocation of annexin II to the endoplasmic reticulum under oxidative stress. 2006.04 Experimental cell research 312 1205-17
Src signaling regulates completion of abscission in cytokinesis through ERK/MAPK activation at the midbody. 2007.02 The Journal of biological chemistry 282 5327-39
Role of Src-family kinases in formation and trafficking of macropinosomes. 2007.04 Journal of cellular physiology 211 220-32
Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes. 2007.07 Experimental cell research 313 2651-66
Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells. 2007.10 Archives of biochemistry and biophysics 466 116-24
Nuclear localization of magphinins, alternative splicing products of the human trophinin gene. 2008.02 Journal of cellular biochemistry 103 765-77
v-Src and c-Src, nonpalmitoylated Src-family kinases, induce perinuclear accumulation of lysosomes through Rab7 in a kinase activity-independent manner. 2008.04 Cancer letters 262 19-27
Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface. 2008.06 Experimental cell research 314 2040-54
Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. 2008.11 Experimental cell research 314 3392-404
Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation. 2008.12 Biochemical and biophysical research communications 377 1227-31
[Regulation of mitosis by mitotic kinases]. 2009.03 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54 441-6
Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. 2009.04 Journal of cell science 122 965-75
Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. 2009.04 Experimental cell research 315 1117-41
Requirement of the SH4 and tyrosine-kinase domains but not the kinase activity of Lyn for its biosynthetic targeting to caveolin-positive Golgi membranes. 2009.10 Biochimica et biophysica acta 1790 1345-52
Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition. 2009.12 The Journal of biological chemistry 284 34223-30
Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. 2010.03 The Journal of biological chemistry 285 7657-69
14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. 2010.08 The EMBO journal 29 2802-12
Nuclear Chk1 prevents premature mitotic entry. 2011.07 Journal of cell science 124 2113-9
P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation. 2012.04 Molecular biology of the cell 23 1582-92
PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3ホウ and is required for metaphase-anaphase transition. 2013 Nature communications 4 1882-
Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. 2014.10 Nature communications 5 5081-
Current topics of functional links between primary cilia and cell cycle. 2015 Cilia 4 12-
Novel insights into Chk1 regulation by phosphorylation. 2015 Cell structure and function 40 43-50
Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis. 2015 PloS one 10 e0133399-
Phospho-Specific Antibody Probes of Intermediate Filament Proteins. 2016 Methods in enzymology 568 85-111
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. 2016.02 The Journal of cell biology 212 409-23
Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues. 2016.09 Biochemical and biophysical research communications 478 1323-9
Sphingosine 1-phosphate signaling through its receptor S1P(5) promotes chromosome segregation and mitotic progression. 2017.03 Science signaling 10
EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. 2018.02 Nature communications 9 758-
Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase. 2018.04 Biochemical and biophysical research communications 498 544-550
Tetraploidy in cancer and its possible link to aging. 2018.09 Cancer science 109 2632-2640
Intermediate filaments and IF-associated proteins: from cell architecture to cell proliferation. 2019 Proceedings of the Japan Academy. Series B, Physical and biological sciences 95 479-493
Primary Cilia as Signaling Hubs in Health and Disease. 2019.01 Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 1801138-
A novel CDK-independent function of p27(Kip1) in preciliary vesicle trafficking during ciliogenesis. 2020.06 Biochemical and biophysical research communications 527 716-722
Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer. 2020.08 International journal of molecular sciences 21