職名 教授
氏名 おかもと りゅうじ
岡本 隆二
生年月 1968.04
所属 部局 附属病院
学科・専攻 臨床研修・キャリア支援部
講座  
教育研究分野 内科、循環器内科
TEL 059-232-1111 内線5648
FAX 059-231-5201
E-mail ryuji@clin.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ  
学歴 1994年三重大学医学部卒
学位 2005年三重大学医学部大学院大学卒
所属学会 日本内科学会 日本循環器学会
社会活動 高血圧治療ガイドライン(2019年度改訂) システマティック・レビュー委員
肥大型心筋症患者を対象とした全国登録調査研究
【調査担当】 高知大学 2018年
難治性副腎疾患の診療に直結するエビデンス創出
【調査担当】 京都医療センター、AMED研究 2018年
狭心症・心筋梗塞 知っておくべき大切なこと あなたと家族を守るために
【講師】 みえ循環器・腎疾患ネットワーク 市民公開講座 2017年
日本循環器学会 慢性虚血性心疾患の診断と病態把握のための検査法の選択基準に関するガイドライン(2010年改訂版)協力員
職歴 1994年 三重大学附属病院   研修医
1995年 鈴鹿中央総合病院   研修医
1996年 茅ヶ崎徳州会総合病院 呼吸器内科医員
1996年 松阪中央総合病院   循環器内科医員 
1998年 三重大学附属病院 循環器内科大学院生
2002年   同    医員       
2005年   同    助手
2006年 米国ハーバード大学ブリガム&ウィメンズ病院循環器内科 リサーチフェロー
2009年 三重大学医学系研究科 循環器腎臓内科学 助教
2014年 三重大学医学部附属病院 循環器腎臓内科 講師、臨床研修・キャリア支援部 専門研修センター長
学術(芸術)賞 上原記念生命科学財団 海外留学助成リサーチフェローシップ,留学助成金,上原記念生命科学財団 
アメリカ心臓学会(AHA) 基礎心血管サイエンス旅費グラント,旅費グラント,アメリカ心臓学会(AHA) 
アメリカ心臓病学会(ACC) 若手研究者賞(YIA),YIA,アメリカ心臓病学会(ACC)
成人血管病研究振興財団 研究助成,研究助成金,成人血管病研究振興財団
三重県医師会 研究奨励賞,研究助成金,2016.12,三重県医師会
専門分野 循環器分子細胞生物学 心筋症、心肥大、高血圧、動脈硬化
現在の研究課題 分子細胞生物学を用いた循環器疾患の原因解明
担当科目 循環器疾患
主な業績等 Quantification of extracellular volume fraction by cardiac computed tomography for noninvasive assessment of myocardial fibrosis in hemodialysis patients
Yamada A, Kitagawa K, Nakamura S, Takafuji M, Goto Y, Okamoto R, Dohi K, Sakuma H.
Sci Rep. 10(1) 15367 2020年10月
Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish.
Okamoto R,Goto I,Nishimura Y,Kobayashi I,Hashizume R,Yoshida Y,Ito R,Kobayashi Y,Nishikawa M,Ali Y,Saito S,Tanaka T,Sawa Y,Ito M,Dohi K
PLoS One. 15(10) e0240129 2020年10月
Acute Pulmonary Thromboembolism in a Patient with Nutcracker Syndrome and Antiphospholipid Syndrome.
Ito T, Okamoto R, Matsuda A, Ogihara Y, Yamada N, Ito M.
Int Heart J 61(4) 856-858 2020年7月
Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism.
Kobayashi Y,Haze T,Yano Y,Tamura K,Kurihara I,Ichijo T,Yoneda T,Katabami T,Tsuiki M,Wada N,Ogawa Y,Kawashima J,Sone M,Inagaki N,Yamada T,Okamoto R,Fujita M,Kamemura K,Yamamoto K,Izawa S,Tanabe A,Naruse M,JPAS/JRAS,Study Group
Kidney Int Rep. 5(8) 1291-1297 2020年6月
Serial cardiac magnetic resonance imaging in wet beriberi.
Murakami H,Fujimoto N,Moriwaki K,Nakata K,Ishida M,Okamoto R,Ito M,Dohi K
J Cardiol Cases 22(3) 100-102 2020年6月
Obesity predicts persistence of resistant hypertension after surgery in patients with primary aldosteronism.
Nakamaru R, Yamamoto K, Rakugi H, Akasaka H, Kurihara I, Ichijo T, Takeda Y, Katabami T, Tsuiki M, Wada N, Ogawa Y, Kawashima J, Sone M, Yoshimoto T, Okamoto R, Fujita M, Kobayashi H, Tamura K, Kamemura K, Okamura S, Kakutani M, Tanabe A, Naruse M,JPAS/JRAS Study Group.
Clinical endocrinology 93(3) 229-237 2020年4月
Diabetes mellitus itself increases cardio-cerebrovascular risk and renal complications in primary aldosteronism.
Saiki A, Otsuki M, Tamada D, Kitamura T, Shimomura I, Kurihara I, Ichijo T, Takeda Y, Katabami T, Tsuiki M, Wada N, Yanase T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Yoshimoto T, Okamoto R, Takahashi K, Kobayashi H, Tamura K, Kamemura K, Yamamoto K, Izawa S, Kakutani M, Yamada M, Tanabe A, Naruse M.
The Journal of clinical endocrinology and metabolism 105(7) dgaa177 2020年4月
Nadir Aldosterone Levels After Confirmatory Tests Are Correlated With Left Ventricular Hypertrophy in Primary Aldosteronism.
Ohno Y, Sone M, Inagaki N, Kawashima A, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Ichijo T, Katabami T, Wada N, Sakamoto R, Ogawa Y, Yoshimoto T, Yamada T, Kawashima J, Matsuda Y, Kobayashi H, Kamemura K, Yamamoto K, Otsuki M, Okamura S, Izawa S, Okamoto R, Tamura K, Tanabe A, Naruse M,JPAS/JRAS Study Group.
Hypertension 75(6) 1475-1482 2020年4月
Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome.
Kobayashi H, Nakamura Y, Abe M, Kurihara I, Itoh H, Ichijo T, Takeda Y, Yoneda T, Katabami T, Tsuiki M, Wada N, Ogawa Y, Sakamoto R, Kawashima J, Sone M, Inagaki N, Yoshimoto T, Yamada T, Okamoto R, Matsuda Y, Fujita M, Watanabe M, Tamura K, Tanabe A, Naruse M,JPAS/JRAS Study Group.
European journal of endocrinology 182(3) 265-273 2020年3月
Basal Plasma Aldosterone Concentration Predicts Therapeutic Outcomes in Primary Aldosteronism.
Saiki A, Otsuki M, Mukai K, Hayashi R, Shimomura I, Kurihara I, Ichijo T, Takeda Y, Katabami T, Tsuiki M, Wada N, Ogawa Y, Kawashima J, Sone M, Inagaki N, Yoshimoto T, Okamoto R, Takahashi K, Kobayashi H, Tamura K, Kamemura K, Yamamoto K, Izawa S, Kakutani M, Yamada M, Tanabe A, Naruse M.
J Endocr Soc. 4(4) bvaa011. 2020年2月
Overlooked pericarditis complicated with cardiac tamponade due to an uncommon cause.
Fukuma T,Okamoto R,Nakata T,Hoshino K,Ito M
Eur Heart J Cardiovasc Imaging 21(1) 116 2020年1月
BNP as a Major Player in the Heart-Kidney Connection.
Okamoto R,Ali Y,Hashizume R,Suzuki N,Ito M
Int J Mol Sci. 20(14) 2019年7月
Angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in hypertensive patients with myocardial infarction or heart failure: a systematic review and meta-analysis
Ohtsubo T,Shibata R,Kai H,Okamoto R,Kumagai E,Kawano H,Fujiwara A,Kitazono T,Murohara T,Arima H
Hypertension Res 42(5) 641-649 2019年5月
Effects of lowering diastolic blood pressure to <80 mmHg on cardiovascular mortality and events in patients with coronary artery disease: a systematic review and meta-analysis.
Okamoto R,Kumagai E,Kai H,Shibata R,Ohtsubo T,Kawano H,Fujiwara A,Ito M,Fukumoto Y,Arima H
Hypertension Res 42(5) 650-659 2019年5月
Novel molecular mechanisms in the inhibition of adrenal aldosterone synthesis: action of Tolvaptan via vasopressin V2 receptor-independent pathway
Yusuf A,Dohi K,Okamoto R,Katayama K,Ito M
Br J Pharmacol. 176(9) 1315-1327 2019年5月
Effects of blood pressure lowering in patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis.
Kawano H, Fujiwara A, Kai H, Kumagai E, Okamoto R, Shibata R, Ohtsubo T, Tamura K, Maemura K, Arima H.
Hypertension research : official journal of the Japanese Society of Hypertension 42(4) 504-513 2019年4月
Predictors of confirmatory test results for the diagnosis of primary hyperaldosteronism in hypertensive patients with an aldosterone-to-renin ratio greater than 20. -The SHRIMP Study-
Okamoto R,Taniguchi M,Onishi Y,Kumagai N,Uraki J,Fujimoto N,Fujii E,Yano Y,Ogura T,Ito M
Hypertension Res 42(1) 40-51 2019年1月
On the Cover. What’s the diagnosis?
Oda K,Katayama K,Joh K,Ishikawa E,Okamoto R,Ito M
Clin J Am Soc Nephrol. 13(11) 2018年11月
Yellow Nail Syndrome Complicating Coronary Artery Bypass Graft Surgery.
Omori T,Okamoto R,Fujimoto H,Masuda J,Kobayashi T,Fujii E,Takei Y,Ito M
Circ J 82(10) 2678-2679 2018年10月
Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes.
Goto I,Okamoto R,Hashizume R,Suzuki N,Ito R,Yamanaka K,Saito H,Kiyonari H,Tawara I,Kageyama Y,Ogihara Y,Ali Y,Yamada N,Katayama N,Ito M
PLoS One 13(5) e0197078 2018年3月
不明熱の原因として、特発性後天性全身性無汗症と診断できた1例と文献的考察
坂野翔子,岡本隆二,鈴木康夫,山本彩人,中谷 仁,村田智博,洪 英在,藤井英太郎,山田典一,伊藤正明
日本内科学会雑誌 107(3) 564-569 2018年3月
Echocardiographic assessment of cardiac structural and functional abnormalities in patients with end-stage renal disease receiving chronic hemodialysis
Hiroshi Matsuo,Kaoru Dohi,Hirofumi Machida,Hideyuki Takeuchi,Toshikazu Aoki,Hiroyuki Nishimura,Masashi Yasutomi,Michiharu Senga,Takehiko Ichikawa,Kentaro Kakuta,Yasuhide Mizutani,Akiko Tanoue,Naoki Isaka,Kazuki Oosugi,Sukenari Koyabu,Masato Sakurai,Yoshihisa Fukui,Hitoshi Kakimoto,Tadafumi Sugimoto,Takahiro Ohnishi,Tomohiro Murata,Eiji Ishikawa,Ryuji Okamoto,Tomomi Yamada,Toru Ogura,Yuki Nishimura,Takashi Tanigawa,Shinsuke Nomura,Masakatsu Nishikawa,Masaaki Ito
Circulation Journal 82(2) 586-595 2018年
Tocilizumab for uncontrollable systemic inflammatory response syndrome complicating adult-onset Still disease Case report and review of literature
Asami Masui-Ito,Ryuji Okamoto,Kaoru Ikejiri,Mika Fujimoto,Muneyoshi Tanimura,Shiro Nakamori,Tomohiro Murata,Eiji Ishikawa,Norikazu Yamada,Hiroshi Imai,Masaaki Ito
MEDICINE 96(29) e7596 2017年7月
左冠動脈回旋枝起始異常を伴ったバルサルバ洞動脈瘤破裂の1例
森脇啓至,土肥 薫,世古哲哉,笠井篤信,岡本隆二,藤井英太郎,山田典一,伊藤正明
心臓 49(3) 268-273 2017年3月
Tracking isolated myocarditis in a young adult with acute rheumatic fever on cardiac magnetic resonance imaging
Keishi Moriwaki,Ryuji Okamoto,Haruno Sakuma,Yasuo Suzuki,Masaki Tanabe,Norikazu Yamada,Masaaki Ito
INTERNATIONAL JOURNAL OF CARDIOLOGY 222(16) 921-923 2016年11月
Hypertensive emergency preceding the progression of periaortitis and retroperitoneal fibrosis: case report and review of the literature
Takayasu Ito,Ryuji Okamoto,Masaya Taniguchi,Masaki Tanabe,Haruna Komatsubara,Norikazu Yamada,Masaaki Ito
BLOOD PRESSURE 25(5) 327-330 2016年10月
Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy
Shota Sasagawa,Yuhei Nishimura,Shiko Okabe,Soichiro Murakami,Yoshifumi Ashikawa,Mizuki Yuge,Koki Kawaguchi,Reiko Kawase,Ryuji Okamoto,Masaaki Ito,Toshio Tanaka
FRONTIERS IN PHARMACOLOGY 7(7) 162 2016年6月
Severely Calcified and Dilated Meandering Mesenteric Artery Complicating Abdominal Aorta Stenosis
Takayasu Ito,Ryuji Okamoto,Takashi Tanigawa,Tatsuya Kawaguchi,Hideo Mizutani,Eitaro Fujii,Norikazu Yamada,Masaaki Ito
CIRCULATION JOURNAL 80(5) 1267-1268 2016年5月
Detrimental Impact of Vasopressin V2 Receptor Antagonism in a SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial Hypertension
Itaru Goto,Kaoru Dohi,Yoshito Ogihara,Ryuji Okamoto,Norikazu Yamada,Yoshihide Mitani,Masaaki Ito
CIRCULATION JOURNAL 80(4) 989-+ 2016年4月
巻頭総説 心肥大及び心不全における,心筋ミオシン軽鎖の リン酸化制御機構について
岡本 隆二,伊藤正明
血管 39(2) 57-61 2016年2月
Tracking Angina Pectoris on the Coronary Fractional Flow Reserve
Shusuke Fukuoka,Ryuji Okamoto,Takashi Tanigawa,Masaaki Ito
INTERNAL MEDICINE 55(16) 2311-2312 2016年
New Isoform of Cardiac Myosin Light Chain Kinase and the Role of Cardiac Myosin Phosphorylation in α1-Adrenoceptor Mediated Inotropic Response.
Taniguchi M,Okamoto R,Ito M,Goto I,Fujita S,Konishi K,Mizutani H,Dohi K,Hartshorne DJ,Itoh T
PLoS One 10(10) e0141130 2015年10月
心臓MRIと18F-FDG PET/CTが心筋生検部位決定および確定診断に有用であった心サルコイドーシスの2例
武内 哲史郎,土肥 薫,大森 拓,中森 史朗,藤本 直紀,岡本 隆二,藤井 英太郎,山田 典一,伊藤 正明
日本心臓病学会学術集会抄録 63回 1307-1307 2015年9月
Effects of cardiac resynchronization therapy on left ventricular mechanical dyssynchrony induced by right ventricular pacing in a patient with heart failure and preserved ejection fraction
Tetsushiro Takeuchi,Kaoru Dohi,Naoto Kumagai,Shiro Nakamori,Naoki Fujimoto,Ryuji Okamoto,Eitaro Fujii,Tetsuya Kitamura,Norikazu Yamada,Mashio Nakamura,Masayuki Hamada,Masaaki Ito
INTERNATIONAL JOURNAL OF CARDIOLOGY 177(3) 1069-1072 2014年12月
Resveratrol sensitizes HepG2 cells to TRAIL-induced apoptosis
Masahiko Tameda,Kazushi Sugimoto,Katsuya Shiraki,Yuji Inagaki,Suguru Ogura,Chika Kasai,Misao Yoneda,Ryuji Okamoto,Norihiko Yamamoto,Yoshiyuki Takei,Masaaki Ito,Tsutomu Nobori
ANTI-CANCER DRUGS 25(9) 1028-1034 2014年10月
Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility
Masahiko Tameda,Kazushi Sugimoto,Katsuya Shiraki,Norihiko Yamamoto,Ryuji Okamoto,Masanobu Usui,Masaaki Ito,Yoshiyuki Takei,Tsutomu Nobori,Takahiro Kojima,Hideaki Suzuki,Masako Uchida,Kazuhiko Uchida
INTERNATIONAL JOURNAL OF ONCOLOGY 45(2) 541-548 2014年8月
Persistent Release of IL-1s from Skin Is Associated with Systemic Cardio-Vascular Disease, Emaciation and Systemic Amyloidosis: The Potential of Anti-IL-1 Therapy for Systemic Inflammatory Diseases
Keiichi Yamanaka,Takehisa Nakanishi,Hiromitsu Saito,Junko Maruyama,Kenichi Isoda,Ayumu Yokochi,Kyoko Imanaka-Yoshida,Kenshiro Tsuda,Masato Kakeda,Ryuji Okamoto,Satoshi Fujita,Yoichiro Iwakura,Noboru Suzuki,Masaaki Ito,Kazuo Maruyama,Esteban C. Gabazza,Toshimichi Yoshida,Motomu Shimaoka,Hitoshi Mizutani
PLOS ONE 9(8) e104479 2014年8月
Fulminant myocarditis in a patient with severe coronary artery disease.
Satoshi Fujita,Ryuji Okamoto,Takeshi Takamura,Hiroshi Nakajima,Masaki Tanabe,Shiro Nakamori,Kaoru Dohi,Takashi Tanigawa,Mashio Nakamura,Masaaki Ito
Journal of cardiology cases 9(1) 15-17 2014年1月
A case of aortic thrombosis and embolism preceding the progression of early esophageal cancer
Itaru Goto,Ryuji Okamoto,Toshiki Sawai,Akihiro Takasaki,Tetsushiro Takeuchi,Hiroshi Matsuo,Masatoshi Miyahara,Mashio Nakamura,Masaaki Ito
Journal of Cardiology Cases 7(5) e123-e125 2013年5月
Identification of bovine hibernation-specific protein complex and evidence of its regulation in fasting and aging
Satoshi Fujita,Ryuji Okamoto,Masaya Taniguchi,Tomomi Ban-Tokuda,Katsuhisa Konishi,Itaru Goto,Yasunari Yamamoto,Kazushi Sugimoto,Nobuhiko Takamatsu,Mashio Nakamura,Katsuya Shiraki,Christa Buechler,Masaaki Ito
JOURNAL OF BIOCHEMISTRY 153(5) 453-461 2013年5月
FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2
Ryuji Okamoto,Yuxin Li,Kensuke Noma,Yukio Hiroi,Ping-Yen Liu,Masaya Taniguchi,Masaaki Ito,James K. Liao
FASEB JOURNAL 27(4) 1439-1449 2013年4月
FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2
Ryuji Okamoto,Yuxin Li,Kensuke Noma,Yukio Hiroi,Ping-Yen Liu,Masaya Taniguchi,Masaaki Ito,James K. Liao
FASEB Journal 27(4) 1439-1449 2013年4月
Marked improvement of renal failure and severe hypertension after renal artery stenting in the solitary functioning kidney
Toshiki Sawai,Masatoshi Miyahara,Ryuji Okamoto,Kaoru Dohi,Takashi Tanigawa,Norikazu Yamada,Mashio Nakamura,Masaaki Ito
Journal of Cardiology Cases 7(3) e82-e85 2013年3月
Notch1 in Bone Marrow-Derived Cells Mediates Cardiac Repair After Myocardial Infarction
Yuxin Li,Yukio Hiroi,Soeun Ngoy,Ryuji Okamoto,Kensuke Noma,Chao-Yung Wang,Hong-Wei Wang,Qian Zhou,Freddy Radtke,Ronglih Liao,James K. Liao
CIRCULATION 123(8) 866-U83 2011年3月
Overexpression of Myosin Phosphatase Reduces Ca2+ Sensitivity of Contraction and Impairs Cardiac Function
Hideo Mizutani,Ryuji Okamoto,Nobuyuki Moriki,Katsuhisa Konishi,Masaya Taniguchi,Satoshi Fujita,Kaoru Dohi,Katsuya Onishi,Noboru Suzuki,Shinji Satoh,Naoki Makino,Takeo Itoh,David J. Hartshorne,Masaaki Ito
CIRCULATION JOURNAL 74(1) 120-128 2010年1月
Statins inhibit Rho kinase activity in patients with atherosclerosis
Anju Nohria,Adnan Prsic,Ping-Yen Liu,Ryuji Okamoto,Mark A. Creager,Andrew Selwyn,James K. Liao,Peter Ganz
ATHEROSCLEROSIS 205(2) 517-521 2009年8月
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor.
Miyata M,Ogita H,Komura H,Nakata S,Okamoto R,Ozaki M,Majima T,Matsuzawa N,Kawano S,Minami A,Waseda M,Fujita N,Mizutani K,Rikitake Y,Takai Y
J Cell Sci 122 4319-4329 2009年
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
Kensuke Noma,Yoshiyuki Rikitake,Naotsugu Oyama,Guijun Yan,Pilar Alcaide,Ping-Yen Liu,Hongwei Wang,Daniela Ahl,Naoki Sawada,Flyuji Okamoto,Yukio Hiroi,Koichi Shimizu,Francis W. Luscinskas,Jianxin Sun,James K. Liao
JOURNAL OF CLINICAL INVESTIGATION 118(5) 1632-1644 2008年5月
High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-kappa B activation in bovine aortic endothelial cells
Hitoshi Iwasaki,Ryuji Okamoto,Shinya Kato,Katsuhisa Konishi,Hideo Mizutam,Norikazu Yamada,Naoki Isaka,Takeshi Nakano,Masaaki Ito
ATHEROSCLEROSIS 196(1) 22-28 2008年1月
Big mitogen-activated protein kinase: A new player in vascular remodeling
Hideo Mizutani,Ryuji Okamoto,Masaaki Ito
HYPERTENSION RESEARCH 30(11) 1015-1016 2007年11月
Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart
Ryuji Okamoto,Takaaki Kato,Akira Mizoguchi,Nobuaki Takahashi,Tetsuya Nakakuki,Hideo Mizutani,Naoki Isaka,Kyoko Imanaka-Yoshida,Kozo Kaibuchi,Zhaojiang Lu,Katsuhide Mabuchi,Terenc Tao,David J. Hartshorne,Takeshi Nakano,Masaaki Ito
CELLULAR SIGNALLING 18(9) 1408-1416 2006年9月
Rho/Rho-kinase pathway contributes to C-reactive protein-induced plasminogen activator inhibitor-1 expression in endothelial cells
T Nakakuki,M Ito,H Iwasaki,Y Kureishi,R Okamoto,N Moriki,M Kongo,S Kato,N Yamada,N Isaka,T Nakano
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 25(10) 2088-2093 2005年10月
The targeted disruption of the MYPT1 gene results in embryonic lethality
R Okamoto,M Ito,N Suzuki,M Kongo,N Moriki,H Saito,H Tsumura,K Imanaka-Yoshida,K Kimura,A Mizoguchi,D Hartshorne,T Nakano
TRANSGENIC RESEARCH 14(3) 337-340 2005年6月
RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
N Moriki,M Ito,T Seko,Y Kureishi,R Okamoto,T Nakakuki,M Kongo,N Isaka,K Kaibuchi,T Nakano
HYPERTENSION RESEARCH 27(4) 263-270 2004年4月
Addition of angiotensin II receptor antagonist to an ACE inhibitor in heart failure improves cardiovascular function by a bradykinin-mediated mechanism
T Koji,K Onishi,K Dohi,R Okamoto,M Tanabe,T Kitamura,M Ito,N Isaka,T Nobori,T Nakano
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 41(4) 632-639 2003年4月
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle
T Seko,M Ito,Y Kureishi,R Okamoto,N Moriki,K Onishi,N Isaka,DJ Hartshorne,T Nakano
CIRCULATION RESEARCH 92(4) 411-418 2003年3月
Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase
K Yamawaki,M Ito,H Machida,N Moriki,R Okamoto,N Isaka,H Shimpo,A Kohda,K Okumura,DJ Hartshorne,T Nakano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 285(4) 1040-1045 2001年7月
Molecular cloning and analysis of the 5 '-flanking region of the human MYPT1 gene
H Machida,M Ito,R Okamoto,K Shiraki,N Isaka,DJ Hartshorne,T Nakano
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1517(3) 424-429 2001年2月
Detection of doxorubicin cardiotoxicity by using iodine-123 BMIPP early dynamic SPECT: Quantitative evaluation of early abnormality of fatty acid metabolism with the Rutland method
K Saito,K Takeda,S Okamoto,R Okamoto,K Makino,Y Tameda,Y Nomura,H Maeda,T Ichihara,T Nakano
JOURNAL OF NUCLEAR CARDIOLOGY 7(6) 553-561 2000年11月
Aorto-coronary dissection during angioplasty in a patient with myxedema
R Okamoto,K Makino,K Saito,M Miyahara,S Okamoto,T Kouji,N Isaka,T Nakano
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION 64(4) 316-320 2000年4月
Acute myocardial infarction in a patient with anomalous left coronary artery origin and primary antiphospholipid syndrome
R Okamoto,K Saito,M Miyahara,S Okamoto,K Makino,R Hirano,M Kimura,T Ohi,A Kouji,N Isaka,T Nakano
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION 64(3) 214-217 2000年3月
急性後下壁心筋梗塞発症5日目に生じた完全房室ブロック に対し,血管形成術が有効であった1例
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