職名 医学部附属病院長 教授
氏名 いさじ しゅうじ
伊佐地 秀司
生年月 1953.05
所属 部局 附属病院
学科・専攻  
講座  
教育研究分野 消化器外科学
TEL 059-232-1111(PHS7521)
FAX 059-232-7498
E-mail isaji-s@clin.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ  
学歴 三重大学医学部 学士課程 (~1979年)
三重大学大学院医学研究科 博士課程・博士後期課程 (~1985年) 卒業・修了
学位 1985.07 医学博士 三重大学
所属学会 日本外科学会 日本消化器外科学会 日本消化器病学会 日本膵臓学会 日本胆道学会 日本肝臓学会 日本肝胆膵外科学会 日本臨床外科学会 日本移植学会 日本内視鏡外科学会 日本癌治療学会 日本腹部救急医学会
社会活動  
職歴 1985. 8 三重大学医学部附属病院 助手
1987.8~88.8 カリフォルニア大学ディビス校外科 研究員
1991.5 三重大医学部附属病院 講師
1994.8 山田赤十字病院外科
1996.10 三重大学医学部附属病院 講師 
1999.10 三重大学医学部 助教授
2006.5 三重大学医学部附属病院 病院教授
2007.12 三重大学大学院医学系研究科 教授
2019.3 定年退職
2019.10 三重大学医学部附属病院病院長(専任)
学術(芸術)賞  
専門分野 研究分野:急性膵炎の病態生理に基づいた治療法の開発,膵広範切除  後の膵再生,膵機能温存手術の開発,肝切除後の肝障害と対策,  消化器癌の悪性度と発癌機序
専門領域:肝胆膵領域の外科治療,生体部分肝移植手術
現在の研究課題  
担当科目  
主な業績等 Experiences and problems preoperative anti-CD20 monoclonal antibody infusion therapy with splenectomy and plasma exchange for ABO-incompatible living-donor liver transplantation 共著 2007.02 Clin Transplant 21 24-31
Use of an interpositional venous graft posterior to the pancreas for LDLT patients with portal vein thrombosis. 共著 2007.03 Hepatogastroenterology 54 541-544
Timing of ischaemia/reperfusion before hepatectomy without inflow occlusion determines liver damage in rats: role of heat shock protein 70. 共著 2007.12 Liver Int 27 1323-1332
Maximizing venous outflow after right hepatic living donor liver transplantation with a venous graft patch. 共著 2008.02 Dig Surg. 25 67-73
Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice. 共著 2008.03 Gut 57 365-373
Survival rates according to the Cancer of the Liver Italian Program scores of 345 hepatocellular carcinoma patients after multimodality treatments during a 10-year period in a retrospective study. 共著 2008.03 J Gastroenterol Hepatol. 23 482-490
Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy. 共著 2008.04 Radiology. 247 260-266
Focal nodular hyperplasia in biliary atresia patient after Kasai hepatic portoenterostomy. 共著 2008.05 Pediatr Surg Int. 24 609-612
Successful laparoscopic splenectomy after living-donor liver transplantation for thrombocytopenia caused by antiviral therapy. 共著 2008.07 World J Gastroenterol. 14 4245-4248
Primary non-Hodgkin's lymphoma of the gallbladder diagnosed by laparoscopic cholecystectomy. 共著 2008.11 J Hepatobiliary Pancreat Surg. 15 659-663
Regulatory mechanisms of C4b-binding protein (C4BP)alpha and beta expression in rat hepatocytes by lipopolysaccharide and interleukin-6. 共著 2008.11 J Thromb Haemost. 6 1858-1867
Assessment of liver graft function and regeneration by galactosyl-human serum albumin (99mTc-GSA) liver scintigraphy in adult living-donor liver transplantation. 共著 2009.04 Clin Transplant. 23 271-277
Stent placement for portal venous stenosis following major abdominal surgery. 共著 2009.04 Hepatogastroenterology. 56 407-410
The impact of total bilirubin on plasma micafungin levels in living-donor liver transplantation recipients with severe liver dysfunction. 共著 2009.04 Biol Pharm Bull. 32 750-754
Tissue factor expression demonstrates severe sinusoidal endothelial cell damage during rejection after living-donor liver transplantation. 共著 2009.04 J Hepatobiliary Pancreat Surg. 16 513-520
Surgical treatment of type IV choledochal cysts. 共著 2009.05 J Hepatobiliary Pancreat Surg. 16 684-687
The effectiveness of measuring for fragmented red cells using an automated hematology analyzer in patients with thrombotic microangiopathy. 共著 2009.05 Clin Appl Thromb Hemost. 15 257-262
Liver retransplantation with external biliary diversion for progressive familial intrahepatic cholestasis type 1: a case report. 共著 2009.08 Pediatr Transplant. 13 611-614
Aggressive surgical resection after neoadjuvant chemoradiation therapy for locally advanced intrahepatic cholangiocarcinoma. 共著 2009.10 Clin J Gastroenterol. 2 351-354
Decreased ADAMTS13 levels in patients after living donor liver transplantation. 共著 2009.11 Thromb Res. 124 541-545
Intraductal papillary neoplasm of bile duct detected on fluorodeoxyglucose-positron emission tomography performed for cancer scanning. 共著 2009.12 Clin Gastroenterol Hepatol. 7 e71-e71
Cutting-edge information for the management of acute pancreatitis. 共著 2010.01 J Hepatobiliary Pancreat Sci. 17 3-12
The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats. 共著 2010.01 Liver Transpl. 16 1-11
Subphrenic versus nonsubphrenic hepatocellular carcinoma: combined therapy with chemoembolization and radiofrequency ablation. 共著 2010.02 AJR Am J Roentgenol. 194 530-535
Development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: proposal of a postoperative NAFLD scoring system. 2010.05 J Hepatobiliary Pancreat Sci. 17 296-304
Prospective study on the outcome of patients with hepatocellular carcinoma registered for living donor liver transplantation: how long can they wait?: 共著 2010.05 Transplantation. 89 650-654
Total vascular hepatic exclusion for tumor resection: a new approach to the intrathoracic inferior vena cava through the abdominal cavity by cutting the diaphragm vertically without cutting the pericardium. 共著 2010.05 J Hepatobiliary Pancreat Sci. 17 197-201
Elevated fibrin-related markers in patients with malignant diseases suspected of having thrombotic disorders. 共著 2010.06 Clin Appl Thromb Hemost. 16 266-272
Therapeutic intervention and surgery of acute pancreatitis. 共著 2010.06 J Hepatobiliary Pancreat Sci. 17 53-59
Treatment strategy for acute pancreatitis. 共著 2010.06 J Hepatobiliary Pancreat Sci. 17 79-86
A standardized technique for safe pancreaticojejunostomy: Pair-Watch suturing technique. 共著 2010.08 World J Gastrointest Surg. 2 260-264
Chemopreventive anti-cancer agent acyclic retinoid suppresses allogeneic immune responses in rats. 共著 2010.08 Int Immunopharmacol. 10 985-989
Has the Partington procedure for chronic pancreatitis become a thing of the past? A review of the evidence. 単著 2010.11 J Hepatobiliary Pancreat Sci. 17 763-769
Indocyanine green (ICG) fluorescence imaging-guided cholangiography for donor hepatectomy in living donor liver transplantation. 共著 2010.12 Am J Transplant. . 10 2725-2726
Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation. 共著 2011.01 Thromb Haemost. 105 40-44
Effect of a prostaglandin I(2) analog on the expression of thrombomodulin in liver and spleen endothelial cells after an extensive hepatectomy. 共著 2011.02 Surg Today. 41 230-236
Monitoring peripheral blood CD4+ adenosine triphosphate activity after living donor liver transplantation: impact of combination assays of immune function and CYP3A5 genotype. 共著 2011.03 J Hepatobiliary Pancreat Sci. 18 226-232
Radiofrequency ablation combined with chemoembolization: treatment of recurrent hepatocellular carcinomas after hepatectomy. 共著 2011.04 AJR Am J Roentgenol. 197 488-494
Nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: association of pancreatic exocrine deficiency and infection. 共著 2011.08 Clin J Gastroenterol. 4 242-248
Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients. 共著 2011.12 Ann Transplant. 16 55-62
Education and imaging. Hepatobiliary and Pancreatic: Aberrant hepatic arteries and pancreatic surgery. 共著 2012.02 J Gastroenterol Hepatol. 27 415-415
Effect of portal haemodynamics on liver graft and intestinal mucosa after small-for-size liver transplantation in swine.:: 共著 2012.03 Eur Surg Res. 48 163-170
Intracellular interferon-γ staining analysis of donor-specific T-cell responses in liver transplant recipients. 共著 2012.03 Transplant Proc. 44 548-554
Living donor liver transplantation for the patients with portal vein thrombosis: use of an interpositional venous graft passed posteriorly to the pancreatic parenchyma without using jump graft. 共著 2012.03 Transplant Proc. 44 356-359
Postoperative liver dysfunction in living donors after left-sided graft hepatectomy: portal venous occlusion of the medial segment after lateral segmentectomy and hepatic venous congestion after left lobe hepatectomy. 共著 2012.03 Transplant Proc. 44 332-337
Stented pancreaticojejunostomy (with video). 共著 2012.03 J Hepatobiliary Pancreat Sci. 19 116-124
Donor age affects liver regeneration during early period in the graft liver and late period in the remnant liver after living donor liver transplantation. 共著 2012.05 World J Surg. 36 1102-1111
Pancreaticoduodenectomy with resection of the splenic artery and splenectomy for pancreatic double cancers after total gastrectomy. Preservation of the pancreatic function via the blood supply from the posterior epiploic artery: report of a case. 共著 2012.05 Surg Today. 42 482-488
Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy. 共著 2012.07 J Hepatobiliary Pancreat Sci. 19 413-425
Impact of histological response after neoadjuvant chemoradiotherapy on recurrence-free survival in UICC-T3 pancreatic adenocarcinoma but not in UICC-T4.: 共著 2012.07 Pancreas. 41 130-136
Is it possible to predict the development of an incisional surgical site infection and its severity after biliary tract surgery for benign disease? 共著 2012.07 J Hepatobiliary Pancreat Sci. 19 389-396
Tumor enucleation with preoperative endoscopic transpapillary stenting for pediatric insulinoma. 共著 2012.07 Pediatr Surg Int. 28 707-709
Dual cytoprotective effects of splenectomy for small-for-size liver transplantation in rats. 共著 2012.11 Liver Transpl. 2012 Nov;18(11):1361-70. 18 1361-1370
Proposal for a morphological classification of intraductal papillary neoplasm of the bile duct (IPN-B). 共著 2013.02 J Hepatobiliary Pancreat Sci. 20 165-172
Behavior of ADAMTS13 and Von Willebrand factor levels in patients after living donor liver transplantation.: 共著 2013.03 Thromb Res. 13 225-229
Combination assays for evaluation of immune function and CYP3A5 genotype to identify the risk of infectious complications and mortality in living donor liver transplant patients. 共著 2013.07 Ann Transplant. 18 349-357
Clinical features and treatment outcome of borderline resectable pancreatic head/body cancer: a multi-institutional survey by the Japanese Society of Pancreatic Surgery. 共著 2013.08 J Hepatobiliary Pancreat Sci. 20 601-610
Randomized, multicenter trial comparing tacrolimus plus mycophenolate mofetil to tacrolimus plus steroids in hepatitis C virus-positive recipients of living donor liver transplantation. 共著 2013.08 Liver Transpl. . 19 896-906
An approach to the intra-thoracic inferior vena cava through the abdominal cavity preparing for total hepatic vascular exclusion by sagittal diaphragmotomy. 共著 2013.09 Hepatogastroenterology. 60 1409-1412
Immunological aspects in late phase of living donor liver transplant patients: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity. 共著 2013.09 Clin Dev Immunol. 2013 982163.-
Immune response following liver transplantation compared to kidney transplantation: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity and cytochrome P450 3A5 genotype assay. 共著 2013.12 Clin Dev Immunol. 2013 936063-
Margin-negative limited resection of metastatic pancreatic tumors from rectal cancer preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsies: report of two cases. 共著 2014.02 Surg Today. 44 366-372
The long-term effects of splenectomy and subsequent interferon therapy in patients with HCV-related liver cirrhosis. 共著 2014.02 Mol Med Rep. 9 487-492
Usefulness of monitoring cell-mediated immunity for predicting post-kidney transplantation viral infection. 共著 2014.02 Transplant Proc. 46 552-555
Biliary complications in 108 consecutive recipients with duct-to-duct biliary reconstruction in living-donor liver transplantation. 共著 2014.04 Transplant Proc. 46 850-855
Gemcitabine-based chemoradiotherapy followed by surgery for borderline resectable and locally unresectable pancreatic ductal adenocarcinoma: significance of the CA19-9 reduction rate and intratumoral human equilibrative nucleoside transporter 1 expression. 共著 2014.04 Pancreas. 43 350-360
Hypertension and hepatitis C virus infection are strong risk factors for developing late renal dysfunction after living donor liver transplantation: significance of renal biopsy. 共著 2014.04 Transplant Proc. 46 804-810
Negative prognostic impact of renal replacement therapy in adult living-donor liver transplant recipients: preoperative recipient condition and donor factors. 共著 2014.04 Transplant Proc. 46 716-720
Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of splenectomy: the significance of ADAMTS13 and graft function [corrected]. 共著 2014.04 Int J Hematol. 99 418-428
Thrombomodulin administration attenuates ischemia-reperfusion injury of the remnant liver after 70% hepatectomy in rats: simulated model of small-for-size graft in living donor liver transplantation. 共著 2014.05 Transplant Proc. 46 1107-1111
Anterior approach to the superior mesenteric artery by using nerve plexus hanging maneuver for borderline resectable pancreatic head carcinoma. 2014.07 J Gastrointest Surg. 18 1209-1215
Incarcerated left diaphragmatic hernia following left hepatectomy for living donor liver transplantation. 共著 2014.07 Transpl Int. 27 e65-e67
A new surgical technique of pancreaticoduodenectomy with splenic artery resection for ductal adenocarcinoma of the pancreatic head and/or body invading splenic artery: impact of the balance between surgical radicality and QOL to avoid total pancreatectomy. 共著 2014.08 Biomed Res Int. 2014 219038-
Clinicopathological factors affecting survival and recurrence after initial hepatectomy in non-B non-C hepatocellular carcinoma patients with comparison to hepatitis B or C virus. 共著 2014.08 Biomed Res Int. 2014 975380-
Laparoscopy assisted middle-segment-preserving pancreatectomy for multiple pancreatic neuroendocrine tumors: report of a case. 共著 2014.08 Asian J Endosc Surg. 7 271-274
Paradoxical impact of the remnant pancreatic volume and infectious complications on the development of nonalcoholic fatty liver disease after pancreaticoduodenectomy. 共著 2014.08 J Hepatobiliary Pancreat Sci. 21 562-572
Benefit of technetium-99m galactosyl human serum albumin scintigraphy instead of indocyanine green test in patients scheduled for hepatectomy. 共著 2014.10 Hepatol Res. 44 E118-E128
Transdiaphragmatic extrapericardial approach of the inferior vena cava. 共著 2014.11 J Am Coll Surg. 219 1096-
Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus-associated liver cirrhosis. 共著 2014.12 Hepatol Res. 44 E376-E385
Early prophylactic antibiotics administration for acute necrotizing pancreatitis: a meta-analysis of randomized controlled trials. 共著 2015.04 J Hepatobiliary Pancreat Sci. 22 316-321
Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. 共著 2015.06 Biomed Res Int. 2015 635041-
Hepatology: Atypical images for multiple focal nodular hyperplasia. 共著 2015.06 J Gastroenterol Hepatol. 30 969-969
Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015. 共著 2015.06 J Hepatobiliary Pancreat Sci. 22 405-432
Revised Japanese guidelines for the management of acute pancreatitis 2015: revised concepts and updated points. 共著 2015.06 J Hepatobiliary Pancreat Sci. 22 433-435
Spontaneous Rupture of an Intrasplenic Aneurysm After Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma. 共著 2015.06 J Emerg Med. 48 729-730
Portal Venous Stent Placement for Malignant Portal Venous Stenosis or Occlusion: Who Benefits? 共著 2015.12 Cardiovasc Intervent Radiol. 38 1515-1522
An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis. 共著 2016.01 Clin Appl Thromb Hemost. 2016 1076029616654263-
Evaluation of the Diagnostic Criteria for the Basic Type of DIC Established by the Japanese Society of Thrombosis and Hemostasis. 共著 2016.01 Clin Appl Thromb Hemost. 2016 1076029616672582-
The efficacy of the administration of recombinant human soluble thrombomodulin in patients with DIC. 共著 2016.02 Int J Hematol. 103 173-179
Factor Analysis Influencing Postoperative Hospital Stay and Medical Costs for Patients with Definite, Suspected, or Unmatched Diagnosis of Acute Cholecystitis according to the Tokyo Guidelines 2013. 共著 2016.04 Gastroenterol Res Pract. 2016 7675953-
Long-Term Results of Stent Placement in Patients with Outflow Block After Living-Donor-Liver Transplantation. 共著 2016.04 Cardiovasc Intervent Radiol. 39 566-574
Discontinuation of Hepatitis B Immunoglobulin by Long-term Hepatitis B Vaccine Inoculation in Preventing Hepatitis B Recurrence After Liver Transplantation. 共著 2016.05 Transplant Proc. 1179 1183-
D-MELD, the Product of Donor Age and Preoperative MELD, Predicts Surgical Outcomes After Living Donor Liver Transplantation, Especially in the Recipients With HCV-positive and Smaller Grafts. 共著 2016.05 Transplant Proc. 48 1025-1031
Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy. 共著 2016.05 Pancreas. 45 761-771
Impact of Splenectomy Just Before Partial Orthotopic Liver Transplantation Using Small-for-Size Graft in Rats. 共著 2016.05 Transplant Proc. 48 1304-1308
Influence of Angiotensin-converting Enzyme Genetic Polymorphism on Late Renal Dysfunction After Adult-to-adult Living-donor Liver Transplantation.:Matsui T, Usui M, Fujinaga K, Nakatani K, Iizawa Y, Kato H, Tanemura A, 共著 2016.05 Transplant Proc. 48 1184-1189
Living Donor Liver Transplantation for Biliary Atresia With Severe Preduodenal Portal Vein Stricture: Success and Pitfall of Portal Vein Reconstruction. 共著 2016.05 Transplant Proc. 48 1218-1220
Long-Term Influence of CYP3A5 Gene Polymorphism on Pharmacokinetics of Tacrolimus and Patient Outcome After Living Donor Liver Transplantation. 共著 2016.05 Transplant Proc. 48 1087-1094
Outcomes of Living Donor Liver Transplantation Alone for Patients on Maintenance Renal Replacement Therapy in Japan: Results of a Nationwide Survey. 共著 2016.05 Transplant Direct. 2 e74-
Pre-operative Assessment of Psychological Characteristics and Mood States in Living Donor Kidney and Liver Transplantation. 2016.05 Transplant Proc. 48 1018-1021
Technical Feasibility and Clinical Outcomes of Interventional Endovascular Treatment for Hepatic Artery Thrombosis After Living-donor Liver Transplantation. 共著 2016.05 Transplant Proc. 48 1142-1148
Clinical utility of radiofrequency ablation following transarterial injection of miriplatin-iodized oil suspension in small hepatocellular carcinoma. 共著 2016.09 Jpn J Radiol. 34 640-646
A Novel Predictor of Posttransplant Portal Hypertension in Adult-To-Adult Living Donor Liver Transplantation: Increased Estimated Spleen/Graft Volume Ratio. 共著 2016.10 Transplantation. 100 2138-2145
Negative Impact of Biliary Candidiasis on Early and Late Postoperative Complications After Pancreatoduodenectomy Usefulness of the CHROMagar Candida Plate for Identification. 共著 2016.10 Pancreas. 45 e45-e47
Mesopancreas is a misnomer: time to correct the nomenclature. 共著 2016.12 J Hepatobiliary Pancreat Sci. 23 745-749
Percutaneous drainage of pancreatic fistula following pancreatectomy with CT-fluoroscopic guidance. 共著 2017.01 Diagn Interv Imaging. 98 43-50
Pretransplant Serum Hyaluronic Acid Can Be a Biomarker as a Prognostic Predictor in Adult-to-Adult Living Donor Liver Transplantation. 共著 2017.02 Transplant Proc. 49 102-108
Role of spleen in hepatic ischemia reperfusion injury: Splenic congestion during ischemia accelerates leukocyte infiltration within the liver after reperfusion. 共著 2017.03 Hepatol Res. 47 E132-E141
Transhepatic Hilar Approach for Perihilar Cholangiocarcinoma: Significance of Early Judgment of Resectability and Safe Vascular Reconstruction. 共著 2017.03 J Gastrointest Surg. 21 590-599
Elevated Soluble Platelet Glycoprotein VI Levels in Patients After Living Donor Liver Transplantation. 共著 2017.04 Clin Appl Thromb Hemost. 23 274-281
Role of curative treatment in patients with intermediate-stage hepatocellular carcinoma.:: 共著 2017.05 Jpn J Radiol. 35 254-261
Significance of Simultaneous Splenic Artery Resection in Left-Sided Portal Hypertension After Pancreaticoduodenectomy with Combined Portal Vein Resection. 共著 2017.08 World J Surg. 41 2111-2120
Superiority of stapled side-to-side gastrojejunostomy over conventional hand-sewn end-to-side gastrojejunostomy for reducing the risk of primary delayed gastric emptying after subtotal stomach-preserving pancreaticoduodenectomy. 共著 2017.08 Surg Today. 47 1007-1017