職名 教授
氏名 はちやいわお
八谷 巌
生年月 1968.06
所属 部局 工学研究科
学科・専攻 分子素材工学専攻
講座 分子設計化学
教育研究分野  
TEL 059-231-9414
FAX 059-231-9413
E-mail hachiya@chem. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ  
学歴 東京理科大学理学部第一部応用化学科 学士課程 (~1991年)
東京理科大学大学院理学研究科化学専攻 博士課程・博士後期課程 (~1996年) 卒業・修了
学位 1996.03 博士(理学) 東京理科大学
所属学会 日本化学会 有機合成化学協会 アメリカ化学会 近畿化学協会 石油学会 ヨウ素学会
社会活動  
職歴 1996.04~1998.03 日本学術振興会 海外特別研究員
1998.04~2000.03 東京理科大学総合研究所基礎科学研究部門 助手
学術(芸術)賞 2001年度有機合成化学協会明治製菓研究企画賞,新規多官能性シクロブテノン合成反応とそれを鍵反応とするβ-ラクタム系抗生物質の合成に関する研究,社団法人有機合成化学協会
2006年度有機合成化学協会東海支部奨励賞,活性メチン化合物のアルキニルイミンおよびケトンへの共役付加反応を用いる新規合成反応,社団法人有機合成化学協会東海支部
有機合成化学奨励賞,アルキニルイミンへの共役付加反応を経る新規へテロ環合成法の開発,社団法人有機合成化学協会
平成30年度長瀬研究振興賞,新規化学種チタンイミドイルヨージドの創製と応用,2018.04,公益財団法人長瀬科学技術振興財団
専門分野 有機合成化学
現在の研究課題 反応集積化による高効率含窒素中分子合成反応の開発
担当科目 化学Ⅱ 精密合成化学演習Ⅰ 精密合成化学演習Ⅱ 精密反応化学演習Ⅰ 精密反応化学演習Ⅱ 精密反応化学特論 分子素材工学特別研究Ⅰ 分子素材工学特別研究Ⅱ 分子素材工学特別研究Ⅲ 分子素材工学特別研究Ⅳ 有機化学B 有機合成化学
主な業績等 Novel 2-Pyrone Synthesis via the Nucleophilic Addiition of Active Methine Compounds to 2-Alkynone 共著 2003.03 Tetrahedron Letters 44 2061-2063
Double Nucleophilic Addition of Ketene Silyl (Thio)acetals and Trimethylsilyl Cyanide to a,b-Unsaturated Aldimines Promoted..... 共著 2003.07 Chemistry Letters 32 606-607
5-Acetyl-2-pyridone Synthesis via Nucleophilic Addition of β-Ketoesters to Alkynyl Imines 共著 2004.06 Synthesis 1349-1352
Stereodivergent Synthesis of (2R)-2,3-Diricinolein by Lipase-catalyzed Hydrolysis of Triricinolein 共著 2004.08 Tetrahedron: Asymmetry 15 2451-2454
3,4,6-Trisubstituted-2-pyrone Synthesis via the Nucleophilic Addition of 2-Alkyl Meldrum’s Acid to Alkynyl Ketone 共著 2004.10 Letters in Organic Chemistry 1 349-352
A Cation-exchange Resin Promoted Imino Aldol Reaction, Leading to the Synthesis of 2-Isocephem and 2-Oxa-isocephem 共著 2004.10 Chemistry Letters 33 1394-1395
Double Nucleophilic Addition of Trimethylsilyl Cyanide to α,β-Unsaturated Aldimines Promoted by Aluminum Chloride: Preparation of 2-Aminopentanedinitrile 共著 2005.10 Chemistry Letters 34 1456-1457
A Cation-exchange Resin Promoted Imino Aldol Reaction of Chiral Alkoxy Ketene Silyl Acetals with α,β-Unsatureted Imines, Leading to a Facile Synthesis of β-Lactams 共著 2005.12 Heterocycles 66 75-80
3,4,5,6-Tetrasubstituted-2-pyridone Synthesis via Nucleophilic Addition of Active Methine Compounds to Dialkynyl Imines Directed to the Synthesis of (-)-A58365A 共著 2006 Heterocycles 69 43-48
Ring Expansion Reaction of Cyclic -Keto Esters or -Cyano Ketones via Conjugate Addition to Alkynyl Imines: The Synthesis of Functionalized Medium-Sized Carbocycles 共著 2006 Synlett 3271-3274
Titanium Tetraiodide Mediated Reductive Opening of Aziridines, Leading to the Aldol and Mannich-Type Reactions 共著 2006 Heterocycles 70 57-64
Synthesis of Bicyclic Compounds Containing a 2-Pyridone Structure by Addition of Malonic Esters to Alkynylpyridines, Pyrimidine, and Thiazoles 共著 2006.01 Heterocycles 67 523-528
活性メチン化合物のアルキニルイミンおよびケトンへの共役付加反応を用いる新規合成反応 共著 2006.03 有機合成化学協会誌 2006
Remarkable Effects of Additives to Facilitate Aza-Mannich Type Reaction: A Rapid Access to -Amino Ketone O-Alkyl Oximes 共著 2006.07 Synlett 1687-1690
Diastereoselective Approach to an HIV Protease Inhibitor Intermediate using a Cation-Exchange Resin Mediated Mannich-Type Reaction 共著 2007 Heterocycles 73 191-195
Diastereoselective Reduction of a-Imino Esters with Tris(trimethylsilyl)aluminum 共著 2007 Heterocycles 72 127-132
Stereodivergent Synthesis of Both (2S)- and (2R)-1-Monoricinolein Derivatives by Lipase-catalyzed Hydrolysis or Transesterification Directed to New Ferroelectric Liquid Crystals 共著 2007 Tetrahedron: Asymmetry 18 915-918
Titanium Tetraiodide Promoted Reductive Opening of 2-(1-Benzyloxyimino- 共著 2007 Heterocycles 74 177-183
Aza-Prins Reaction Promoted by Titanium Tetraiodide and Iodine 共著 2007.01 Chemistry Letters 36 12-13
Regioselective Double Nucleophilic Addition Reaction Leading to the Synthesis of β-Lactams 共著 2008 Heterocycles 76 203-208
Synthesis of N-Allylideneamines and Their Use for the Double Nucleophilic Addition of Ketene Silyl (Thio)acetals and Trimethylsilyl Cyanide 共著 2008 Organic Letters 10 3977-3980
3-Iodo-3-trimethylsilylpropenal as a Useful Unit for Pinacol Coupling and Subsequent Functional Group Transformations 共著 2008.01 Chemistry Letters 37 28-29
Synthesis of Multi-substituted 2-Iminopyridine Using Conjugate Addition of Ethyl Cyanoacetate Derivatives to Alkynyl Imines 共著 2008.03 European Journal of Organic Chemistry 1411-1417
Conjugate Imines and Iminium Salts as Versatile Acceptors of Nucleophile 共著 2009 Chemical Communications 874-889
Titanium Tetraiodide Induced Cyclization of 2-(2-Cyanoalk-1-enyl) β-Keto Esters into 2-Iodopyridines, 共著 2009.04 Heterocycles 79 365-371
N-Allylideneamines Derived from Acrolein: Synthesis and Use as Acceptors of Two Nucleophiles 共著 2009.08 European Journal of Organic Chemistry 4073-4084
Stereodivergent Synthesis of β-Lactams Using Thermal Rearrangement of Aminocyclobutenones 共著 2009.08 Organic Letters 11 3266-3268
A New Method for the Synthesis of Multisubstituted Pyrroles of Biological Interest by Double Nucleophilic Addition to α,β-Unsaturated Imines 共著 2010.01 European Journal of Organic Chemistry 191-200
A New Method for the Synthesis of Multisubstituted Pyrroles of Biological Interest by Double Nucleophilic Addition to α,β-Unsaturated Imines 共著 2010.03 Chemistry-an Asian Journal 5 473-477
Facile Synthesis and Ring-Opening of 4-(Tributylstannyl)pyrrolidine-2-carboxylates 共著 2010.03 Heterocycles 80 773-778
Use of N-Allylidene-1,1-diphenylethanamine as a Latent Acrolein Synthon in the Double Nucleophilic Addition Reaction of Ketene Silyl (Thio)acetals and Allylborolanes 共著 2010.08 Organic Letters 12 3571-3573
Titanium Tetraiodide-promoted Tandem Prins Reaction of Alkynes with Acetals: Synthesis of (Z,Z)-1,5-Diiodo-1,3,5-triarylpenta-1,4-dienes 共著 2010.10 Chemistry Letters 39 1052-1054
α,β-不飽和イミンへの共役付加反応を用いる新規合成反応 共著 2010.10 有機合成化学協会誌 68 1006-1016
Synthesis of 3,4-Ethylenedioxythiophene (EDOT) from (Z)-But-2-ene-1,4-diol or But-3-yne-1,4-diol 共著 2010.12 Heterocycles 82 449-460
Titanium Tetraiodide-Promoted Reductive Enolate Formation of α-Tosyloxy Ketone Derivatives and Aldol Reaction with Aldehydes 共著 2011.04 Bulletin of the Chemical Society of Japan 84 419-421
Double Nucleophilic Addition to Acrolein with Ketene Silyl Acetals and Allylborolanes Catalyzed by Proline 共著 2011.08 Chemistry Letters 40 862-863
Reductive Aminopropylation of Ketene Silyl (Thio)Acetals Leading to The Synthesis of δ-Amino Esters, 共著 2011.10 Tetrahedron Letters 52 5388-5391
Regioselective Ring-Opening Reaction of 2-Mono-Substituted Azetidin-3-ones Promoted by the Combined Use of Titanium Tetraiodide and Its Chloro or Bromo Counterpart 共著 2012.01 Heterocycles 84 301-307
Synthesis of Nitrogen-containing Heterocycles Using Conjugate Addition Reactions of Nucleophiles to α,β-Unsaturated Imines 共著 2012.05 Heterocycles 85 993-1016
Synthesis of α-Amino Ketones and O-Alkyloximes by Titanium Tetrahalide Promoted Ring-Opening Reaction of 2-Mono-Substituted Azetidin-3-ones and Their O-Alkyloximes 共著 2012.12 Heterocycles 86 1187-1210
Diastereoselective Iodoaldol Reaction of γ-Alkoxy-α,β-Alkynyl Ketone Derivatives Promoted by Titanium Tetraiodide 共著 2013.10 Asian Journal of Organic Chemistry 2 931-934
Two-Step Synthesis of 3,4-Ethylenedioxythiophene (EDOT) from 2,3-Butanedione 共著 2014.01 Heterocycles 88 607-612
Chemoselective reductions and iodinations using titanium tetraiodide 共著 2014.04 Tetrahedron Letters 55 2781-2787
Chiral β-Lactam Synthesis through the Enantioselective Reduction of Iminocyclobutenones and the Thermal Rearrangement of Aminocyclobutenones 共著 2014.05 Asian Journal of Organic Chemistry 3 614-618
Titanium Tetraiodide Mediated Organic Reactions 共著 2014.09 Arabian Journal for Science and Engineering 39 6599-6616
2-Aryl-4-quinolone Synthesis Using the Thermal Rearrangement of Iminocyclobutenones 共著 2015.01 Heterocycles 90 97-103
Synthesis of (±)-muscopyridine analogue using ring-expansion reaction of cyclic β-keto ester via conjugate addition to alkynyl imine 共著 2015.09 Tetrahedron 71 5824-5829
Titanium Tetraiodide-Mediated Diastereoselective Iodo-Aldol and Mannich Reactions of β-Alkoxy-α,β-Alkynyl Ketone Derivatives 共著 2016.10 Tetrahedron 72 6875-6885
Titanium Tetraiodide Induced Cyclization of Cyanoketones into 3-Aryl-1-Iodoisoquinolines 共著 2016.11 Heterocycles 92 2032-2046
Synthesis of 2-Aminopyridinium Salts from 2-Iminopyridines as a Starting Material 共著 2017.12 Heterocycles 94 2215-2221
四ヨウ化チタンの ヨードチタン化能力を活用する 新規合成反応 共著 2017.12 有機合成化学協会誌 75 1226-1237
Synthesis of α-Carbolines Using Palladium-Catalyzed Intramolecular Amination of 3-(2-Chlorophenyl)-2-Aminopyridines 共著 2019.01 ChemistrySelect 4 469-472
第5版実験化学講座 18 共著 2004.09 丸善株式会社
Encyclopedia of Reagents for Organic Synthesis 2008 Wiley
使える有機合成反応241実践ガイド 共著 2010.04 化学同人
ヨウ素の化学と最新応用技術 共著 2011.07 シーエムシー出版
PEDOTの材料物性とデバイス応用 共著 2012.03 サイエンス&テクノロジー