職名 教授
氏名 やまなかけいいち
山中 恵一
生年月 1969.01
所属 部局 医学系研究科
学科・専攻 生命医科学専攻
講座 臨床医学系講座
教育研究分野  
TEL 059-231-5025
FAX 059-231-5206
E-mail yamake@clin.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ  
学歴 三重大学医学部 学士課程 (~1993年)
三重大学大学院医学研究科 博士課程・博士後期課程 (~2000年) 満了
学位 2000.07 医学博士 三重大学
所属学会 日本皮膚科学会 日本研究皮膚科学会 日本乾癬学会 米国研究皮膚科学会 日本熱傷学会 日本アレルギー学会
社会活動  
職歴  
学術(芸術)賞  
専門分野 皮膚科学 アレルギー性炎症 Caspase family
現在の研究課題  
担当科目  
主な業績等 Scleroderma renal crisis complicated by hemolytic uremic syndrome in a case of elderly onset systemic sclerosis. 共著 1997.03 The Journal of dermatology 24 3 184-8
Intradermal transfer of caspase-1 (CASP1) DNA into mouse dissects: role of CASP1 in interleukin-1beta associated skin inflammation and apoptotic cell death. 共著 1999.09 Journal of dermatological science 21 1 49-58
Cassiopeia flap: modification of Limberg flap for saving normal skin. 共著 2000.03 The Journal of dermatology 27 3 217-9
A case of acute graft-versus-host disease following autologous peripheral blood stem cell transplantation. 共著 2000.07 The Journal of dermatology 27 7 446-9
Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. 2000.07 Journal of immunology (Baltimore, Md. : 1950) 165 2 997-1003
IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. 2000.08 Nature immunology 1 2 132-7
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. 共著 2002.08 Proceedings of the National Academy of Sciences of the United States of America 99 17 11340-5
Bilateral scalp necrosis with giant cell arteritis. 共著 2003.03 The Journal of dermatology 30 3 210-5
Animal models of psoriasis and pustular psoriasis. 共著 2003.04 Archives of dermatological research 295 Suppl 1 0-8
Persistent secretion of IL-18 in the skin contributes to IgE response in mice. 共著 2003.05 International immunology 15 5 611-21
Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. 共著 2003.12 Blood 102 12 4059-66
Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis. 共著 2004.09 The Journal of dermatology 31 9 731-6
Extra nodal NK/T-cell lymphoma nasal type that responded to DeVIC combination chemotherapy. 2005.03 The Journal of dermatology 32 3 204-9
Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma. 共著 2005.08 Clinical cancer research : an official journal of the American Association for Cancer Research 11 16 5748-55
Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy. 共著 2005.09 European journal of dermatology : EJD 15 5 411-3
Human skin cells support thymus-independent T cell development. 共著 2005.11 The Journal of clinical investigation 115 11 3239-49
Activation of neutrophils in cutaneous T-cell lymphoma. 共著 2005.12 Clinical cancer research : an official journal of the American Association for Cancer Research 11 23 8243-9
Basic fibroblast growth factor treatment for skin ulcerations in scleroderma. 共著 2005.12 Cutis; cutaneous medicine for the practitioner 76 6 373-6
Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. 共著 2006.01 Clinical cancer research : an official journal of the American Association for Cancer Research 12 2 376-82
Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma. 2006.03 Blood 107 6 2440-5
The vast majority of CLA+ T cells are resident in normal skin. 共著 2006.04 Journal of immunology (Baltimore, Md. : 1950) 176 7 4431-9
A novel method for the isolation of skin resident T cells from normal and diseased human skin. 共著 2006.05 The Journal of investigative dermatology 126 5 1059-70
Cytokeratin expression in subungual squamous cell carcinoma. 2006.07 The Journal of international medical research 34 4 441-3
Topical suplatast tosilate (IPD) ameliorates Th2 cytokine-mediated dermatitis in caspase-1 transgenic mice by downregulating interleukin-4 and interleukin-5. 共著 2006.07 The British journal of dermatology 155 1 27-32
Cutaneous dermoid cyst: cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland. 2006.08 Oncology reports 16 2 295-9
Cytokeratin expression in trichilemmal carcinoma suggests differentiation towards follicular infundibulum. 共著 2006.09 In vivo (Athens, Greece) 20 5 583-5
A novel acoustic evaluation system of scratching in mouse dermatitis: rapid and specific detection of invisibly rapid scratch in an atopic dermatitis model mouse. 2006.10 Life sciences 79 22 2144-50
The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. 共著 2006.10 Journal of immunology (Baltimore, Md. : 1950) 177 7 4488-94
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. 共著 2006.12 Journal of immunology (Baltimore, Md. : 1950) 177 12 8315-9
Pinkus tumor may originate from intraepidermal eccrine ducts and proliferate in the dermis. 2007.01 Oncology reports 17 1 49-54
Pilonidal sinus of the supra-auricle area. 共著 2007.02 Journal of the European Academy of Dermatology and Venereology : JEADV 21 2 257-8
Cytokeratin and filaggrin expression in nevus comedonicus. 共著 2007.04 Journal of cutaneous pathology 34 4 338-41
Filaggrin expression and the pathogenesis of epidermal cysts. 共著 2007.08 The British journal of dermatology 157 2 415-6
Cytokeratin expression in squamous cell carcinoma arising from hidradenitis suppurativa (acne inversa). 共著 2007.09 Journal of cutaneous pathology 34 9 675-8
Magnetic resonance (MR) imaging-induced deep second-degree burns of lower extremities by conducting loop. 共著 2007.09 Journal of the European Academy of Dermatology and Venereology : JEADV 21 8 1140-1
A case of Adamantiades-Behcet disease with ischemic optic neuritis (posterior optic neuropathy). 共著 2007.11 Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 5 11 1010-4
Necrobiotic xanthogranuloma with paraproteinemia; an atypical case. 共著 2008.01 Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 6 1 40-3
Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression. 共著 2008.01 The Journal of allergy and clinical immunology 121 1 148-157000
Keratin and filaggrin expression in keratoacanthoma. 共著 2008.03 Journal of the European Academy of Dermatology and Venereology : JEADV 22 3 353-5
Protective role of interleukin-18 against Fas-mediated liver injury. 共著 2008.07 International journal of molecular medicine 22 1 43-8
Enhanced production and secretion of glial cell line-derived neurotrophic factor and nerve growth factor from the skin in atopic dermatitis mouse model. 共著 2008.08 Archives of dermatological research 300 7 343-52
Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells. 共著 2009.02 Archives of dermatological research 301 2 151-7
Folliculosebaceous cystic hamartoma differentiates toward the infundibulum, sebaceous duct and sebaceous cells: immunohistochemical study of keratins and filaggrin. 共著 2009.02 The British journal of dermatology 160 2 454-6
IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis. 共著 2009.06 The British journal of dermatology 160 6 1172-9
Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease. 共著 2009.07 Journal of dermatological science 55 1 47-52
Induction of IL-10-producing regulatory T cells with TCR diversity by epitope-specific immunotherapy in pollinosis. 共著 2009.08 The Journal of allergy and clinical immunology 0-0
Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge. 共著 2009.08 Experimental dermatology 18 8 734-7
Leg ulcer caused by Mycobacterium ulcerans ssp. shinshuense infection. 共著 2009.12 International journal of dermatology 48 12 1330-3
Immunohistochemical study of cytokeratin expression in nevus sebaceous. 共著 2010.04 International journal of dermatology 49 4 402-5
1,24-Dihydroxyvitamin D (tacalcitol) prevents skin T-cell infiltration. 共著 2010.06 The British journal of dermatology 162 6 1206-15
Granzyme B is a novel interleukin-18 converting enzyme. 共著 2010.08 Journal of dermatological science 59 2 129-35
Possible case for false-positive reaction in serum 5-S-cysteinyldopa levels in a patient with malignant melanoma by ingestion of Agaricus blazei Murrill extract. 共著 2010.08 The Journal of dermatology 37 8 773-5
Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma. 共著 2010.08 Archives of dermatological research 302 6 453-9
Epidermal cyst with pilomatricoma (follicular hybrid cyst): immunohistochemical study with epithelial keratins and filaggrin. 共著 2010.10 The Journal of dermatology 37 10 922-5
Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses. 共著 2011 PloS one 6 12 29020-0
The role of cytokines/chemokines in the pathogenesis of atopic dermatitis. 単著 2011 Current problems in dermatology 41 80-92
High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma. 共著 2011.02 Blood 117 6 1966-76
Propionibacterium acnes vaccination induces regulatory T cells and Th1 immune responses and improves mouse atopic dermatitis. 共著 2011.02 Experimental dermatology 20 2 157-8
SLIT improves cedar pollinosis by restoring IL-10 production from Tr1 and Monocytes approximately IL-10 productivity is critical for becoming allergic approximately . 共著 2011.03 Allergology international : official journal of the Japanese Society of Allergology 60 1 45-51
Treatment of cloth with a fabric softener ameliorates skin dryness. 共著 2011.07 The Journal of dermatology 38 7 685-92
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokine-producing mature T cells. 共著 2012 PloS one 7 2 31465-0
Single step modified ink staining for Tzanck test: quick detection of herpetic giant cells in Tzanck smear. 共著 2012.02 The Journal of dermatology 39 2 138-40
Complete remission of advanced extramammary Paget's disease treated with docetaxel: a case report. 共著 2012.03 Clinical and experimental dermatology 37 2 194-5
Intratumoral injection of OK-432 suppresses metastatic squamous cell carcinoma lesion inducing interferon-gamma and tumour necrosis factor-alpha. 共著 2012.03 Clinical and experimental dermatology 37 2 193-4
Heat-killed bacillus Calmette-Guerin and Mycobacterium kansasii antigen 85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells. 共著 2012.05 The British journal of dermatology 166 5 953-63