| 教員紹介トップページへ | 三重大学トップページへ |
| 職名 | 教授 | |||||||||
| 氏名 | いまなか－よしだきょうこ 今中－吉田 恭子 |
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| imanaka@doc.medic. (末尾に mie-u.ac.jp を補ってください) | ||||||||||
| 個人のホームページ | http://www.medic.mie-u.ac.jp/pathol_matrix | |||||||||
| 学歴 | 三重大学医学部 学士課程 (～1984年)
三重大学大学院医学研究科 博士課程・博士後期課程 (～1988年) 卒業・修了 |
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| 学位 | 1988 医学博士
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| 所属学会 | 日本病理学会、日本循環器学会、日本細胞生物学会、American Society for Cell Biology | |||||||||
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| 学術（芸術）賞 | ||||||||||
| 専門分野 | 循環器病理学 細胞生物学 発生生物学 | |||||||||
| 現在の研究課題 | 心血管組織リモデリングの分子機序の解明 | |||||||||
| 担当科目 | 生命医科学特論 病理学各論 病理学総論 分子医科学 分子生命体科学 | |||||||||
| 主な業績等 | Binding of alphavbeta1 and alphavbeta6 integrins to tenascin-C induces epithelial-mesenchymal transition-like change of breast cancer cells. 共著 2013 Oncogenesis 2 e65-
New insights into the developmental mechanisms of coronary vessels and epicardium. 共著 2013 International review of cell and molecular biology 303 263-317 Atrial natriuretic peptide exerts protective action against angiotensin II-induced cardiac remodeling by attenuating inflammation via endothelin-1/endothelin receptor A cascade. 共著 2013.01 Heart and vessels 14C-Methionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion. 共著 2013.03 Journal of nuclear medicine : official publication, Society of Nuclear Medicine 54 431-6 Pitavastatin Regulates Helper T-Cell Differentiation and Ameliorates Autoimmune Myocarditis in Mice. 共著 2013.05 Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Preliminary study of serum tenascin-C levels as a diagnostic or prognostic biomarker of type B acute aortic dissection. 共著 2013.06 International journal of cardiology Rats with metabolic syndrome resist the protective effects of N-acetyl l-cystein against impaired spermatogenesis induced by high-phosphorus/zinc-free diet. 共著 2013.06 Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie Tenascin-C induces prolonged constriction of cerebral arteries in rats. 2013.07 Neurobiology of disease 55 104-9 Arrhythmogenic right ventricular cardiomyopathy in a 20-year-old woman with systemic sclerosis. 共著 2014 Internal medicine (Tokyo, Japan) 53 973-7 Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases. 2014 PloS one 9 e104479- Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system. 共著 2014 Frontiers in physiology 5 283- Tenascin C protects aorta from acute dissection in mice. 共著 2014.02 Scientific reports 4 4051- Tenascin-C in development and disease of blood vessels. 共著 2014.09 Anatomical record (Hoboken, N.J. : 2007) 297 1747-57 Gellan sulfate core platinum coil with tenascin-C promotes intra-aneurysmal organization in rats. 共著 2014.10 Translational stroke research 5 595-603 Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation. 共著 2014.12 Journal of the American Heart Association 3 e001052- Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion. 共著 2015 EJNMMI research 5 21- Effects of tenascin-C on early brain injury after subarachnoid hemorrhage in rats. 共著 2015 Acta neurochirurgica. Supplement 120 69-73 Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats. 共著 2015 PloS one 10 e0118655- Tenascin-C and integrins in cancer. 共著 2015 Cell adhesion & migration 9 96-104 Tenascin-C is a possible mediator between initial brain injury and vasospasm-related and -unrelated delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. 共著 2015 Acta neurochirurgica. Supplement 120 117-21 Vasoconstrictive effect of tenascin-C on cerebral arteries in rats. 共著 2015 Acta neurochirurgica. Supplement 120 99-103 JNK is critical for the development of Candida albicans-induced vascular lesions in a mouse model of Kawasaki disease. 共著 2015.01 Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 24 33-40 Angiotensin II type 1 receptor blockers suppress neointimal hyperplasia after stent implantation in carotid arteries of hypercholesterolemic rabbits. 共著 2015.02 Neurological research 37 147-52 Effect of tenascin-C on the repair of full-thickness osteochondral defects of articular cartilage in rabbits. 2015.04 Journal of orthopaedic research : official publication of the Orthopaedic Research Society 33 563-71 Impact of serum tenascin-C on the aortic healing process during the chronic stage of type B acute aortic dissection. 共著 2015.07 International journal of cardiology 191 97-9 Anti-Vascular Endothelial Growth Factor Treatment Suppresses Early Brain Injury After Subarachnoid Hemorrhage in Mice. 共著 2015.08 Molecular neurobiology Recurrent inflammatory aortic aneurysms in chronic mucocutaneous candidiasis with a gain-of-function STAT1 mutation. 共著 2015.10 International journal of cardiology 196 88-90 Tenascin-C may accelerate cardiac fibrosis by activating macrophages via the integrin alphaVbeta3/nuclear factor-kappaB/interleukin-6 axis. 共著 2015.10 Hypertension 66 757-66 Extracellular Matrix Remodeling in Vascular Development and Disease 単著 2016 221-226 The Role of Matricellular Proteins in Brain Edema after Subarachnoid Hemorrhage. 共著 2016 Acta neurochirurgica. Supplement 121 151-6 Aneurysm Organization Effects of Gellan Sulfate Core Platinum Coil with Tenascin-C in a Simulated Clinical Setting and the Possible Mechanism. 共著 2016.04 Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 25 771-80 Deficiency of tenascin-C and attenuation of blood-brain barrier disruption following experimental subarachnoid hemorrhage in mice. 共著 2016.06 Journal of neurosurgery 124 1693-702 Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats. 共著 2016.07 Brain research 1642 436-44 Anti-Vascular Endothelial Growth Factor Treatment Suppresses Early Brain Injury After Subarachnoid Hemorrhage in Mice. 共著 2016.09 Molecular neurobiology 53 4529-38 Serum Tenascin-C as a Novel Predictor for Risk of Coronary Artery Lesion and Resistance to Intravenous Immunoglobulin in Kawasaki Disease- A Multicenter Retrospective Study. 共著 2016.10 Circulation journal : official journal of the Japanese Circulation Society 80 2376-2381 Depletion of Neural Crest-Derived Cells Leads to Reduction in Plasma Noradrenaline and Alters B Lymphopoiesis. 共著 2017.01 Journal of immunology 198 156-169 Effects of Tenascin-C Knockout on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice. 共著 2017.02 Molecular neurobiology Fulminant Myocarditis With Prolonged Active Lymphocytic Infiltration After Hemodynamic Recovery. 共著 2017.04 International heart journal 58 294-297 Role of Periostin in Early Brain Injury After Subarachnoid Hemorrhage in Mice. 共著 2017.04 Stroke 48 1108-1111 A Survival Case of Fulminant Right-Side Dominant Eosinophilic Myocarditis. 共著 2017.05 International heart journal 58 459-462 Native T1 Mapping and Extracellular Volume Mapping for the Assessment of Diffuse Myocardial Fibrosis in Dilated Cardiomyopathy. 共著 2018.01 JACC. Cardiovascular imaging 11 48-59 Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models. 共著 2018.01 Cartilage 9 80-88 Effects of Tenascin-C Knockout on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice. 共著 2018.03 Molecular neurobiology 55 1951-1958 Multiple Roles of Tenascins in Homeostasis and Pathophysiology of Aorta. 共著 2018.06 Annals of vascular diseases 11 169-180 Tenascin-C in brain injuries and edema after subarachnoid hemorrhage: Findings from basic and clinical studies. 共著 2018.09 Journal of neuroscience research A case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization. 共著 2018.11 Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 37 54-57 Deficiency of Tenascin-C Alleviates Neuronal Apoptosis and Neuroinflammation After Experimental Subarachnoid Hemorrhage in Mice. 共著 2018.11 Molecular neurobiology 55 8346-8354 Expression of tenascin C in cardiovascular lesions of Kawasaki disease. 共著 2019.01 Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 38 25-30 Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C. 共著 2019.01 International heart journal 60 151-158 Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization. 共著 2019.03 Cardiovascular research 115 614-624 Influenza-associated septic shock accompanied by septic cardiomyopathy that developed in summer and mimicked fulminant myocarditis. 共著 2019.04 Acute medicine & surgery 6 192-196 Tenascin-C promotes the repair of cartilage defects in mice. 共著 2019.04 Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association Tenascin-C-coated platinum coils for acceleration of organization of cavities and reduction of lumen size in a rat aneurysm model. 共著 2005.10 Journal of neurosurgery 103 681-6 Method of cell transplantation promoting the organization of intraarterial thrombus. 共著 2005.08 Circulation 112 0-6 The targeted disruption of the MYPT1 gene results in embryonic lethality. 共著 2005.06 Transgenic research 14 337-40 Expression of matrix metalloproteinase-3 in mouse endometrial stromal cells during early pregnancy: regulation by interleukin-1alpha and tenascin-C. 共著 2005.08 Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 21 111-8 Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. 共著 2005.07 The American journal of pathology 167 71-80 MMP-2 expression is associated with rapidly proliferative arteriosclerosis in the flexor tenosynovium and pain severity in carpal tunnel syndrome. 共著 2005.03 The Journal of pathology 205 443-50 Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis. 共著 2005.03 The Journal of pathology 205 460-7 Tenascin-C is an essential factor for neointimal hyperplasia after aortotomy in mice. 共著 2005.02 Cardiovascular research 65 737-42 Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse. 共著 2006.12 European journal of immunology 36 3334-45 Development of a new method for endovascular aortic repair: combination therapy of cell transplantation and stent grafts with a drug delivery system. 共著 2006.07 Circulation 114 0-83 Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. 共著 2006.12 Oncogene 25 7673-9 In vitro model for mouse coronary vasculogenesis. 共著 2006.07 The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 288 714-22 Serum tenascin-C might be a novel predictor of left ventricular remodeling and prognosis after acute myocardial infarction. 共著 2006.06 Journal of the American College of Cardiology 47 2319-25 Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome. 共著 2006.05 Histology and histopathology 21 511-8 Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. 共著 2006.09 Cellular signalling 18 1408-16 Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation. 共著 2006.01 Developmental dynamics : an official publication of the American Association of Anatomists 235 94-104 A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy. 共著 2006.01 Nature medicine 12 128-32 Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse:involvement of tenascin-C induce by aldosterone-mediated inflammation 共著 2007.05 J Cardiovasc Pharmacol 49 261-268 Tenascin-C synthesized in both donor grafts and recipients accelerates artery graft stenosis 共著 2007.03 Cardiovasc Res 74 366-376 Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C. 共著 2007.04 Journal of hepatology 46 664-73 Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy. 共著 2007.03 Circulation journal : official journal of the Japanese Circulation Society 71 327-30 Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice. 共著 2007.01 The Journal of pathology 211 86-94 Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis 共著 2007 J Autoimmun 29 146-153 A Nuclear Factor-{kappa}B Inhibitor Pyrrolidine Dithiocarbamate Ameliorates Pulmonary Hypertension in Rats. 共著 2007.10 Chest 132 1265-1274 Locally applied cilostazol suppresses neointimal hyperplasia and medial thickening in a vein graft model. 共著 2007.10 Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of A 13 322-30 Fate of the "opened" arterial duct: Lessons learned from bilateral pulmonary artery banding for hypoplastic left heart syndrome under the continuous infusion of prostaglandin E1 共著 2007.05 J Thorac Cardiovasc Surg 133 1653-1654 Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation. 共著 2008.12 Developmental biology 324 310-9 Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111 In Fab fragment of monoclonal antibody specific for tenascin-C. 共著 2008.07 International heart journal 49 481-92 Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: a canine model experiment. 共著 2008.11 Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascu 48 1306-14 Atrial natriuretic peptide gene transfection with a novel envelope vector system ameliorates pulmonary hypertension in rats. 共著 2008.07 The Journal of thoracic and cardiovascular surgery 136 142-9 Cerebrospinal fluid tenascin-C increases preceding the development of chronic shunt-dependent hydrocephalus after subarachnoid hemorrhage. 共著 2008.05 Stroke; a journal of cerebral circulation 39 1610-2 High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty: expression of tenascin C as a possible marker for inflammation. 共著 2009.07 Human pathology 40 1015-22 T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. 共著 2009.11 Proceedings of the National Academy of Sciences of the United States of America 106 18604-9 Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure. 共著 2009.12 Journal of cardiac failure 15 898-905 Dynamic expression of tenascin-C after myocardial ischemia and reperfusion: assessment by 125I-anti-tenascin-C antibody imaging. 共著 2010.07 Journal of nuclear medicine : official publication, Society of Nuclear Medicine 51 1116-22 Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. 2010.03 American journal of physiology. Heart and circulatory physiology 298 0-8 Conventional therapy with an ACE inhibitor diminishes left ventricular dyssynchrony during the progression of heart failure. 共著 2010.04 International journal of cardiology 140 48-54 Deficiency of tenascin-C delays articular cartilage repair in mice. 共著 2010.06 Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 18 839-48 Tenascin-C is induced in cerebral vasospasm after subarachnoid hemorrhage in rats and humans: a pilot study. 共著 2010.03 Neurological research 32 179-84 Tenascin-C enhances crosstalk signaling of integrin alphavbeta3/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells. 共著 2011.07 Journal of cellular physiology 226 2617-2624 Cerebrospinal fluid tenascin-C in cerebral vasospasm after aneurysmal subarachnoid hemorrhage. 共著 2011.10 Journal of neurosurgical anesthesiology 23 310-7 Developmental defects of coronary vasculature in rat embryos administered bis-diamine. 共著 2011.02 Birth defects research. Part B, Developmental and reproductive toxicology 92 10-16 Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C. 共著 2011.12 Analytical chemistry 83 9123-30 Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process. 共著 2011.10 Pathology international 61 559-64 Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development. 共著 2011.06 Differentiation; research in biological diversity 81 299-306 Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. 共著 2011.02 The American journal of pathology 178 754-63 Imatinib mesylate prevents cerebral vasospasm after subarachnoid hemorrhage via inhibiting tenascin-C expression in rats. 共著 2012.04 Neurobiology of disease 46 172-9 Prognostic value of serum tenascin-C levels on long-term outcome after acute myocardial infarction. 共著 2012.06 Journal of cardiac failure 18 480-6 Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis. 共著 2012.08 Journal of immunology 189 2043-53 Tenascin-C in cardiovascular tissue remodeling. 単著 2012.10 Circulation journal : official journal of the Japanese Circulation Society 76 2513-20 循環器疾患の最新医療 共著 2012.10 寺田国際事務所／先端医療技術研究所 目でみる循環器シリーズ 心筋症 共著 2007.03 メジカルビュー 先天性心疾患を理解するための臨床心臓発生学 共著 2007.10 メジカルビュー 研修医のための病理マニュアル 2008.05 診断と治療社 ますます重要になる細胞周辺環境（細胞ニッチ）の最新科学技術 共著 2009.03 メディカルドゥ Annual Review 循環器 共著 2011.01 中外医学社 厚生労働省難治性克服研究事業 特発性心筋症に関する調査研究 共著 厚生労働省難治性疾患等克服研究事業 炎症性動脈瘤形成症候群の新規診断法の確立に関する研究 統括・分担報告書 共著 厚生労働省難治性疾患等克服研究事業 特発性心筋症に関する調査研究 共著 厚生労働省難治性疾患等政策研究事業 炎症性動脈瘤形成症候群の病態診断及び治療法選択に関する研究総括報告書 単著 厚生労働省難治性疾患等克服研究事業 特発性心筋症に関する調査研究 共著 厚生労働省難治性疾患等克服研究事業 特発性心筋症に関する調査研究 共著 心筋線維化分子機構の解明とテネイシンCを標的とした線維化予防法の開発 単著 心臓冠動脈発生における心臓該細胞の関与-先天性心疾患モデルラット全胚培養での検討 共著 テネイシンCを分子標的とした心筋梗塞後リモデリング治療法開発のための基礎的研究 単著 厚生労働省難治性克服研究事業 特発性心筋症に関する調査研究 共著 厚生労働省難治性克服研究事業 特発性心筋症に関する調査研究 共著 厚生労働省難治性克服研究事業 特発性心筋症に関する調査研究 共著 肥大心の間質線維化病変の可逆性に関する基礎的研究と治療法の開発 単著 厚生労働省難治性克服研究事業 特発性心筋症に関する調査研究 共著 厚生労働省国際医療研究委託費研究報告書 21指118 共著 厚生労働省国際医療研究委託費研究報告書 21指117 共著 厚生労働省難治性克服研究事業 特発性心筋症に関する調査研究 共著 厚生労働省難治性克服研究事業 特発性心筋症に関する調査研究 共著 心筋リモデリング時の間質細胞の動態を制御する分子機構に関する基礎的研究 単著 厚生労働省難治性克服研究事業 炎症性動脈瘤形成症候群の新規バイオマーカー開発と診断基準の作成に関する研究 統括・分担報告書 共著 |
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