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職名 |
教授 | |
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氏名 |
にしむらゆうへい 西村 有平 | |
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生年月 |
1968 | |
所属 |
部局 |
医学系研究科 |
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学科・専攻 |
生命医科学専攻 | |
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講座 |
基礎医学系講座 | |
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教育研究分野 |
統合薬理学 | |
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TEL |
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FAX |
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E-mail |
yuhei@doc.medic. (末尾に mie-u.ac.jp を補ってください) | |
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個人のホームページ |
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学歴 |
三重大学医学部 学士課程 (1987年04月～1993年03月) 卒業・修了
三重大学大学院医学研究科 博士課程・博士後期課程 (1995年04月～) 満了 | |
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学位 |
1993.03 医学士 三重大学
2002.03 医学博士 三重大学 | |
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所属学会 |
日本薬理学会 日本心脈管作動物質学会 日本毒性学会 日本ケミカルバイオロジー学会 日本先天異常学会 日本神経化学会 日本分子生物学会 北米神経科学学会 日本オミックス医療学会 日本眼薬理学会 日本循環薬理学会 | |
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社会活動 |
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職歴 |
1993.06～1995.03 東京逓信病院 内科系研修医
1998.04～2002.04 三重大学 文部科学教官教育職 助手 2002.05～2014.07 三重大学 文部科学教官教育職 講師 2014.08～2017.01 三重大学 文部科学教官教育職 准教授 2004.09～2007.08 UCLA自閉症研究治療センター 客員研究員 | |
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学術（芸術）賞 |
第75回日本薬理学会年会優秀発表賞,トランスクリプトーム解析による転写因子NFIL3/E4BP4のカルシウム依存性遺伝子発現制御と機能解析,2002.03,日本薬理学会
Young Investigator Award,Identification of candidate genes for autism spectrum disorder,2005,Cure Autism Now Foundation 三重大学医学部・大学院医学系研究科教育貢献賞,2016 Congenital Anomalies Award,Zebrafish as a systems toxicology model for DNT,2018.07,The Japanese Teratology Society | |
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専門分野 |
薬理学、毒性学、ケミカルバイオロジー、バイオインフォマティクス | |
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現在の研究課題 |
情報科学とモデル生物を用いた統合薬理学 | |
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担当科目 |
薬理学 | |
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主な業績等 |
Editorial: Drug Repositioning: Current Advances and Future Perspectives. 共著 2018.10 Frontiers in pharmacology 9 1068-
Tetraploidy in cancer and its possible link to aging. 共著 2018.06 Cancer science EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. 共著 2018.02 Nature communications 9 758- Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch. 共著 2017.11 Scientific reports 7 16128- Overcoming Obstacles to Drug Repositioning in Japan. 共著 2017.10 Frontiers in pharmacology 8 729- Using zebrafish in drug discovery for nervous system disorders. 単著 2017.08 Nihon yakurigaku zasshi. Folia pharmacologica Japonica 150 88-91 New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae. 共著 2017.07 Documenta ophthalmologica. Advances in ophthalmology Oxidative Stress in Retinal Diseases. 共著 2017.03 Oxidative medicine and cellular longevity 2017 4076518- Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. 共著 2017.03 Heliyon 3 e00266- Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases. 共著 2016.12 Oxidative medicine and cellular longevity 2016 2370252- Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish. 共著 2016.07 Frontiers in pharmacology 7 206- Downregulation of GSTK1 is a common mechanism underlying hypertrophic cardiomyopathy 共著 2016.06 FRONT PHARMACOL 7 162- Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish 共著 2016.06 J PHARMACOL SCI Comparative transcriptome analysis identifies CCDC80 as a novel gene associated with pulmonary arterial hypertension 共著 2016.05 FRONT PHARMACOL 7 142- EP300 protects from light-induced retinopathy in zebrafish 共著 2016.05 FRONT PHARMACOL 7 126- E2F4 promotes neuronal regeneration and functional recovery after spinal cord injury in zebrafish 共著 2016.05 FRONT PHARMACOL 7 119- DNA damage response is involved in the developmental toxicity of mebendazole in zebrafish retina. 共著 2016.03 FRONT PHARMACOL 7 57- Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs 共著 2016.03 Fundam. Toxicol. Sci. 3 79-87 In vivo detection of mitochondrial dysfunction induced by clinical drugs and disease-associated genes using a novel dye ZMJ214 in zebrafish. 共著 2016.01 ACS CHEM BIOL 11(2) 381- Using zebrafish in systems toxicology for developmental toxicity testing. 共著 2016.01 CONGENIT ANOM 56(1) 18- Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. 共著 2016.01 TRANSL RES 170 89- Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers. 共著 2015.11 FRONT PHARMACOL 6 257- Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. 共著 2015.09 FRONT PHARMACOL 6 199- Repeated Blood Collection for Blood Tests in Adult Zebrafish. 共著 2015.08 Journal of visualized experiments : JoVE e53272- E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. 共著 2015.05 NUTR METAB 12 17- In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3). 共著 2015.06 BIOMATERIALS 52 14- Repeated blood collection for blood tests in adult zebrafish. 共著 2015.08 JOVE-J VIS EXP 102 e53272- Zebrafish as a systems toxicology model for developmental neurotoxicity testing 共著 2015.02 CONGENIT ANOM 55(1) 1-16 Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity 共著 2015.02 TOXICOL SCI 143(2) 374-384 In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion. 共著 2014.12 STROKE 45(12) 3698-3703 Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR. 共著 2014.10 MOL PSYCHIATR Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors 共著 2014.12 TUMOR BIOL 35(12) 11861-11869 Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression 共著 2014.09 FEBS LETT 588(18) 3409-3416 Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. 共著 2014.08 INT J OBESITY 38(8) 1053-1060 Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation 共著 2014.01 PLOS ONE 9(1) e85439- Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. 共著 2014.01 SCI REP-UK 4 3708- Zebrafish-based systems pharmacology of cancer metastasis. 共著 2014 Methods Mol Biol. 1165 223-238 S-nitrosylation regulates mitochondrial quality control via activation of parkin 共著 2013.07 SCI REP-UK Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models. 共著 2013.05 ACS CHEM NEUROSCI Fluorescent-based methods for gene knockdown and functional cardiac imaging in zebrafish. 共著 2013.05 MOL BIOTECHNOL A novel method for repeated blood collection from adult zebrafish 共著 2013.05 ZEBRAFISH A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. 共著 2012.12 PLOS ONE 7(12) e52549- SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells. 共著 2012.09 INVEST OPHTH VIS SCI 53(10) 6729-6737 In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. 共著 2012.08 BMC NEUROSCI 16;13: 101.- Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. 共著 2012.08 NUTR METAB 9(1) 73- Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. 共著 2011.12 NUTR METAB 8: 88.- In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. 共著 2010 BMC NEUROSCI 11 116-0 Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. 共著 2010 BMC physiology 10 21-0 Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. 共著 2009.10 GENE 446 18-27 Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. 共著 2008.02 BMB REP 41 139-145 Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. 共著 2008.05 J PHARMACOL SCI 107 8-14 Heterogeneous dysregulation of microRNAs across the autism spectrum. 共著 2008.07 NEUROGENETICS 9 153-161 Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. 共著 2007.07 HUM MOL GENET 16 1682-1698 Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. 共著 2006.12 BIOCHEM BIOPH RES CO 351 185-191 Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage 共著 2004.04 CIRCULATION 110 1839-1846 Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene 共著 2002.10 BIOCHEM BIOPH RES CO 297 1253-1258 Molecular cloning of novel mouse and human putative citrate lyase beta-subunit 共著 2001.12 BIOCHEM BIOPH RES CO 289 1282-1286 Calcium-dependent activation of nuclear factor regulated by interleukin 3/adenovirus e4 promoter-binding protein gene expression 共著 2001.06 J BIOL CHEM 276 19921-19928 Pharmacogenomics and therapeutic target validation in cerebral vasospasm. 共著 2000 J CARDIOVASC PHARM 36 1-4 Transcriptional and post-transcriptional regulation of monocyte chemoattractant protein-3 gene expression in human endothelial c 共著 2000.04 IMMUNOLOGY 99 561-568 Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associate 共著 1999.01 BIOCHEM BIOPH RES CO 254 21-26 眼薬理（ゼブラフィッシュによるシステムズ眼薬理学） 共著 2015 生体の科学（cAMP/cGMPシグナル） 共著 2015 実験医学 （システムズ薬理学を用いた次世代創薬） 共著 2012.08 羊土社 心と体のクロストークから解く精神・神経疾患 実験医学別冊(トランスクリプトーム解析を用いた精神疾患のトランスレーショナルリサーチ) 共著 2012.06 羊土社 図説 分子細胞生物学事典(シグナル伝達) 共著 2012.12 みみずく舎 血管生物医学事典(カルモデュリンとカルモデュリン依存性プロテインキナーゼ) 共著 2011.12 朝倉書店 血管生物医学事典(PKC) 共著 2011.12 朝倉書店 医科薬理学(血管平滑筋作用薬) 共著 2005 南山堂 生物薬科学実験講座７ 情報伝達物質Ⅱ 2005 廣川書店 | |