職名 産学官連携講座教授
氏名 みぞぐち あきら
溝口 明
生年月 1953.08
所属 部局 医学系研究科
TEL 059-231-5687
FAX 059-231-5263
E-mail amizomie@doc.medic. (末尾に mie-u.ac.jp を補ってください)
学歴 神戸大学医学部 学士課程 (~1980年)
神戸大学医学部大学院 博士課程・博士後期課程 (~1984年) 卒業・修了
学位 1984.03 医学博士 神戸大学
所属学会 日本解剖学会 日本組織細胞化学会 日本神経科学学会 日本電子顕微鏡学会 日本生化学学会
社会活動 岐阜大学医学部,非常勤講師
職歴 1984.12~1989.09 神戸大学医学部 助手
1989.10~1996.07 神戸大学医学部 講師 講師
1996.08~2001.01 京都大学大学院医学研究科 助教授
2001.02~2019.03 三重大学医学部 教授 教授
学術(芸術)賞 三重大学知的財産優秀出願賞,平成26年度三重大学知的財産表彰,2015.01
専門分野 電子顕微鏡(解剖学)
担当科目 組織学各論 組織学実習各論 組織学実習総論 組織学総論
主な業績等 1. Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway. 共著 2020.10 Kidney Int. 98 1179-1192
2. Cryo-EM structure of a Ca2+-bound photosynthetic LH1-RC complex containing multipleαβ-polypeptides. 共著 2020.10 Nat Commun. 11 4955-
3. A novel CDK-independent function of p27 Kip1 in preciliary vesicle trafficking during ciliogenesis 共著 2020.06 Biochem Biophys Res Commun. 527 716-722
4. A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis. 共著 2020.04 Nat Commun. 11 1539—
5. Inhibition of SNAT5 Induces Incretin Responsive State From Incretin Unresponsive State in Pancreatic β-cells: Study of β-cell Spheroid Clusters as a Model. 共著 2018.09 Diabetes. 67 1795-1806
6. A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II. 共著 2018.05 Mol Ther. 26 1366-1374
7. EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. 共著 2018.02 Nat Commun. 9 758.
8. Nectin-1 Spots Regulate the Branching of Olfactory Mitral Cell Dendrites. 共著 2015.09 Mol Cell Neurosci. 68 143-150
9. Real-time histological imaging of kidneys stained with food dyes using multiphoton microscopy. 共著 2015.08 Microsc Res Tech. 78 847-858
10. Imaging neutrophil extracellular traps in the alveolar space and pulmonary capillaries of a murine sepsis model by multiphoton microscopy. 共著 2015.05 Am J Respir Crit Care Med. 191 1088-1089
11. Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity. 共著 2015.05 Nat Neurosci. 18 698-707
12. In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion. 共著 2014.10 Stroke 45 3698-3703
13. Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion. 共著 2014.10 Cell Reports 9 661-673
14. In vivo optical pathology of paclitaxel efficacy on the peritoneal metastatic xenograft model of gastric cancer using two-photon laser scanning microscopy. 共著 2014.01 Gastric Cancer. 18 109-118.
15. Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. 共著 2014.01 Development. 141 399-409
16. Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues. 共著2012.11 Cell Structure and Function 37 155-175
17. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. 共著2012.10 J Cell Biol. 199 331-345
18. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. 共著2011.12 Human molecular genetics 20 4666-83
19. Intravital three-dimensional dynamic pathology of experimental colitis in living mice using two-photon laser scanning microscopy. 共著 2011.10 Journal of gastrointestinal surgery 15 1842-1850
20. Rim2alpha Determines Docking and Priming States in Insulin Granule Exocytosis. 共著2010.08 Cell Metab. 12 117-129
21. Triple N-glycosylation in the long S5-P loop regulates the activation and trafficking of the Kv12.2 potassium channel. 共著2009.11 J Biol Chem. 284 33139-33150
22. Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis 共著 2009.04 Genes Cells. 14 445-456
23. Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7. 共著 2009.02 Cancer Sci. 100 608-616
24. Establishment of cell polarity by afadin during the formation of embryoid bodies. 共著 2008.01 Genes Cells 13 79-90
25. Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. 共著2007.11 Neuron 56 456-471
26. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. 共著2007.03 J Neurosci. 27 2472-2482
27. Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer. 共著2007.02 Nat Biotechnol 25 233-237
28. Protruding disordered loop of gC1qR is specifically exposed and related to antiapoptotic property in germ cell lineage. 共著2006.12 Histochem Cell Biol. 126 665-677
29. Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus. 共著2006.02 Mol Cell Neurosci. 31 315-325
30. Implications of the Aquaporin-4 Structure on Array Formation and Cell Adhesion. 共著2006.01 J Mol Biol. 355 628-639
31. Choroid plexus ependymal cells host neural progenitor cells in the rat. 共著2006.01 Glia. 53 32-42
32. The targeted disruption of the MYPT1 gene results in embryonic lethality. 共著 2005.06 Transgenic Res. 14 337-340
33. Nectin-like molecule-1/TSLL1/ SynCAM3:a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. 共著2005.05 J Cell Sci. 118 1267-1277
34. A novel mode of action of an ArfGAP, AMAP2/PAG3/Papalpha, in Arf6 function. 共著 2004.07 J Biol Chem. 279 37677-37684
35.The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. 共著2004.01 J Neurosci. 24 43-52
36. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. 共著2003.12 Nat Med. 9 1477-1483
37. Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for neural stem/progenitor cells. 共著 2003.09 J Biol Chem. 278 35491-35500
38. Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. 共著 2003.04 Proc Natl Acad Sci U S A. 100 4132-4137
39. A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. 共著 2002.10 Proc Natl Acad Sci U S A. 99 14536-14541
40. Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors. 共著 2002.07 EMBO Rep. 3 674-681
41. Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes. 共著 2002.07 Stroke. 33 1911-1915
42. Cadherin regulates dendritic spine morphogenesis. 共著 2002.07 Neuron 35 77-89
43. Nectin: an adhesion molecule involved in formation of synapses. 共著 2002.02 J Cell Biol. 156 555-565
44. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. 共著 2001.12 Cell 107 789-800
45. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. 共著 2001.09 Proc Natl Acad Sci U S A. 98 11674-11679
46. Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. 共著 2001.05 Mol Biol Cell. 12 1421-1430
47. An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. 共著 2001.03 Mol Biol Cell. 645-662
48. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. 共著 2001.01 Science. 291 319-322
49. Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. 共著2000.12 J Comp Neurol. 428 62-78
50. Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina. 共著2000.12 Invest Ophthalmol Vis Sci. 41 4268-4274
51. Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission. 共著 2000.10 Proc Natl Acad Sci U S A. 97 11587-11592
52. Localization of l-afadin at puncta adhaerentia-like junctions between the mossy fiber terminals and the dendritic trunks of pyramidal cells in the adult mouse hippocampus. 共著 2000.08 J Comp Neurol. 424 297-306
53. Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments. 共著 2000.05 Genes Cells. 5 203-210
54. Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. 共著 2000.04 J Biol Chem. 275 10291-10299
55. Prostaglandin D2 as a mediator of allergic asthma. 共著 2000.03 Science. 287 2013-2017
56. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. 共著 2000.01 J Cell Sci. 113 103-112