| 教員紹介トップページへ | 三重大学トップページへ |
| 職名 | 教授 | |||||||||
| 氏名 | こばやし てつ 小林 哲 |
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| ktetsu@med. (末尾に mie-u.ac.jp を補ってください) | ||||||||||
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| 学歴 | 三重大学医学部 学士課程 (～1991年)
三重大学医学部大学院 博士課程・博士後期課程 (～) |
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| 学位 | 2000.07 医学博士 三重大学
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| 所属学会 | 日本内科学会総合内科専門医
日本呼吸器学会指導医 日本呼吸器内視鏡学会指導医 日本ｱﾚﾙｷﾞｰ学会指導医 がん治療認定医機構認定医 日本結核病学会結核・抗酸菌症指導医 日本医師会認定産業医 インフェクションコントロールドクター（ICD） 日本学術振興会 科学研究費委員会専門委員（2012/12/1～2014/11/30、2021/11/1～2023/10/31） 米国胸部学会誌(ATS) Editorial board (2015年～) 日本呼吸器学会東海支部長(2020年5月～2022年4月) 日本呼吸器学会理事（2022年4月～） 日本結核・非結核性抗酸菌症学会理事（2021年6月～） 日本サルコイドーシス/肉芽腫性疾患学会理事（2024年10月～） 日本肺癌学会評議員（2018年12月～） 日本呼吸器内視鏡学会評議員（2015年4月～） 日本アレルギー学会代議員（2024年10月～） |
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| 職歴 | 1991 三重大学医学部附属病院第３内科
1992~ 国立津病院内科,公立紀南病院内科,岡波総合病院内科,松阪市民病院内科,三重大学医学部附属病院 2000~2005 米国University of Nebraska Medical Center呼吸器内科部門 2006~ 三重大学医学部附属病院呼吸器内科 2015/4~ 同 診療科長 2015/12~ 同 病院教授 2021/7~三重大学大学院医学系研究科臨床医学系講座 呼吸器内科学分野/代謝内分泌内科学分野 教授 |
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| 学術（芸術）賞 | 第19回臨床喘息研究会学術講演会 優秀演題賞（2011/11/19大阪）
第84回閉塞性肺疾患研究会 優秀演題賞（2012/1/28東京） 第85回閉塞性肺疾患研究会 優秀演題賞（2012/7/21東京） 第20回臨床喘息研究会学術講演会 優秀演題賞（2012/10/6金沢） 平成27年度公益信託岡本敏記念肺線維症研究基金受賞（2015/8/22東京） |
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| 専門分野 | 呼吸器内科学 | |||||||||
| 現在の研究課題 | RNAiを用いた創薬
Drug repositioningの研究 呼吸器疾患におけるmicrobiomeの研究 組織リモデリングの制御 肺癌発生の制御 抗がん剤耐性機構の制御を用いた創薬 |
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| 担当科目 | 結核
呼吸器内科領域 呼吸機能検査 |
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| 主な業績等 | Inhibiting Invariant Natural Killer T-Cell Activation: A Promising Strategy against Pulmonary Fibrosis.
Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T. Am J Respir Crit Care Med.2024 Nov15;210(10):1278. Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis. Fujimoto H, D'Alessandro-Gabazza CN, Yasuma T, Gabazza EC, Hataji O, Kobayashi T. Am J Respir Crit Care Med. 2024 Aug 15;210(4):527-528. Role of microbiota-derived corisin in coagulation activation during SARS-CoV-2 infection. Tsuruga T, Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Ito T, Tomaru A, Saiki H, Okano T, Alhawsawi MAB, Takeshita A, Nishihama K, Takei R, Kondoh Y, Cann I, Gabazza EC, Kobayashi T. J Thromb Haemost. 2024 Jul;22(7):1919-1935. Adenine Nucleotide Translocases and Cellular Senescence in Idiopathic Pulmonary Fibrosis. Kobayashi T, Fujimoto H, D'Alessandro-Gabazza CN, Yasuma T, Gabazza EC. Am J Respir Cell Mol Biol. 2024 Mar;70(3):226. Epoprostenol and Treprostinil: Differential Effects on Regulatory T-Cell Generation in Patients with Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2023 Dec 1;208(11):1248. Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions. Sci Rep. 2023 Sep 7;13(1):14724. Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury. Am J Pathol. 2023 Jun;193(6):740-754. Inflammation during Pregnancy Predisposes to Childhood Asthma by Altering Long Noncoding RNA Expression. Am J Respir Cell Mol Biol. 2023 Jun;68(6):599-600. Next-generation sequencing clarified why first-line treatment with osimertinib was ineffective in an autopsied case of EGFR-mutated lung squamous cell carcinoma. Thorac Cancer. 2023 Mar;14(7):709-713. Risk factors for disease progression in fibrotic hypersensitivity pneumonitis. Eur Respir J. 2023 Jan 27;61(1):2201706. Is the Urokinase Plasminogen Activator/Plasminogen Activator Inhibitor-1 Ratio a Marker of Sonographic Septations in Pleural Infection? Am J Respir Crit Care Med. 2023 Apr 1;207(7):949. Is Helicobacter pylori infection inversely correlated with atopic, skin, and autoimmune diseases? Allergy. 2022 Oct;77(10):3165-3166. Efficacy and Safety of Amrubicin in Small Cell Carcinoma Previously Treated with Immune Checkpoint Inhibitors and Chemotherapy. Cancers (Basel). 2022 Aug 16;14(16):3953. Microbial Burden-associated Cytokine Storm May Explain Nonresolving Acute Respiratory Distress Syndrome in Patients with COVID-19. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1182-1183. Is the Efficacy of Adding Ramucirumab to Docetaxel Related to a History of Immune Checkpoint Inhibitors in the Real-World Clinical Practice? Cancers (Basel). 2022 Jun 16;14(12):2970. The Need for a CYFRA 21-1 Cutoff Value to Predict Clinical Progression of IPF in Clinical Practice. Am J Respir Crit Care Med. 2022 Sep 1;206(5):648-649. Correlation of total serum HDL particles with a predictor of mortality risk in idiopathic pulmonary fibrosis. Eur Respir J. 2022 Apr 14;59(4):2103175. Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis. Nat Commun. 2022 Mar 23;13(1):1558. The Clinical Relevance of Infection and Its Treatment in Microscopic Polyangiitis With or Without Interstitial Lung Disease. Chest. 2021 Dec;160(6):e682-e683. Response of Lung Microbiota to Changes of Pulmonary Innate Immunity Under Healthy Conditions. Am J Respir Crit Care Med. 2022 Feb 15;205(4):477. The Clinical Relevance of Infection and Its Treatment in Microscopic Polyangiitis With or Without Interstitial Lung Disease. Chest. 2021 Dec;160(6):e682-e683. Role of activation of the coagulation system in the pathogenesis of urticaria. Allergy. 2021 Oct;76(10):3243-3244. The role of cigarette smoking-derived pollutants in the risk of mortality in idiopathic pulmonary fibrosis. Eur Respir J. 2021 Sep 9;58(3):2101372. No Strong Evidence for Ruling Out the Role of Coagulation in Long-Term Disability after Critical Illness. Am J Respir Crit Care Med. 2021 Sep 1;204(5):613. Second-line therapy with first- or second-generation tyrosine kinase inhibitors in EGFR-mutated non-small cell lung cancer patients with T790M-negative or unidentified mutation. Thorac Cancer. 2021 Apr;12(7):1067-1073. Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis. Front Pharmacol. 2020 Nov 27;11:593620. De Novo T790M Mutation in an L858R Epidermal Growth Factor Receptor Mutant-Associated Lung Adenocarcinoma. Cancers (Basel). 2020 Oct 21;12(10):3074. Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway. Kidney Int. 2020 Nov;98(5):1179-1192. A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis. Nat Commun. 2020 Mar 24;11(1):1539. Too Premature to Deny the Potential of Thrombomodulin-alfa in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 Jun 1;201(11):1449-145 Protein S protects against allergic bronchial asthma by modulating Th1/Th2 balance. Allergy. 2020 Sep;75(9):2267-2278. Factors leading to failure to diagnose pulmonary malignant tumors using endobronchial ultrasound with guide sheath within the target lesion. Respir Res. 2019 Sep 12;20(1):207. Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma. Front Immunol. 2019 Aug 2;10:1795. Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis. Int J Mol Sci. 2019 Mar 2;20(5). Retrospective Comparison of the Clinical Efficacy of Gefitinib, Erlotinib, and Afatinib in Japanese Patients With Non-Small Cell Lung Cancer. Oncol Res. 2018Aug 23;26(7):1031-1036. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus. Metabolism. 2018 May;82:88-99. Efficacy of osimertinib in a patient with non-small cell lung cancer harboring epithelial growth factor receptor exon 19 deletion/T790M mutation, with poor performance status. Mol Clin Oncol. 2018Feb;8(2):246-249. Mice overexpressing latent matrix metalloproteinase-2 develop lung emphysema after short-term exposure to cigarette smoke extract. Biochem Biophys Res Commun. 2018 Feb 26;497(1):332-338. Risks of Treating Idiopathic Pulmonary Fibrosis with a TAM Receptor Kinase Inhibitor. Am J Respir Crit Care Med. 2018 Oct 1;198(7):970-971. Comparable immunoreactivity rates of PD-L1 in archival and recent specimens from non-small cell lung cancer. Thorac Cancer. 2018Nov;9(11):1476-1482. Renal Injury during Long-Term Crizotinib Therapy. Int J Mol Sci. 2018 Sep 25;19(10). Identification of Halophilic Microbes in Lung Fibrotic Tissue by Oligotyping. Front Microbiol. 2018 Aug 30;9:1892. Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling. Front Immunol. 2018Sep 20;9:2163. Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis. Gene Ther. 2017 Nov;24(11):706-716. Inhibition of Cell Apoptosis and Amelioration of Pulmonary Fibrosis by Thrombomodulin. Am J Pathol. 2017 Oct;187(10):2312-2322. Recent studies move closer to answering questions about sequential therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer. J Thorac Dis. 2017 Sep;9(9):2847-2851. Β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells. Respir Res. 2017 May 2;18(1):79. Sequential Therapy with Crizotinib and Alectinib in ALK-Rearranged Non-Small Cell Lung Cancer-A Multicenter Retrospective Study. J Thorac Oncol. 2017 Feb;12(2):390-396. Sequential Use of ALK Inhibitors: An Optional Approach. J Thorac Oncol. 2016Dec;11(12):e153-e154. Efficacy of crizotinib in ALK fusion variants. J Thorac Dis. 2016 Oct;8(10):E1381-E1383. Pseudoprogression of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. J Thorac Oncol. 2016 Oct;11(10):e117-9. Protein S is protective in pulmonary fibrosis. J Thromb Haemost. 2016 Aug;14(8):1588-99. Amelioration of Diabetes by Protein S. Diabetes. 2016 Jul;65(7):1940-51. Activated protein C modulates the proinflammatory activity of dendritic cells. J Asthma Allergy. 2015 May 7;8:29-37. Matrix metalloproteinase-9 activates TGF-ß1 and stimulates fibroblast contraction of collagen gels. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1006-15. Thrombin-Activatable Fibrinolysis Inhibitor Protects Against Acute Lung Injury by Inhibiting the Complement System. Am J Respir Cell Mol Biol. 2013 Oct;49(4):646-53. Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells. PLoS One. 2013；8(5):e64281. Efficacy of a novel class of RNA interference therapeutic agents. PLoS One. 2012;7(8):e42655. Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis. Am J Respir Cell Mol Biol. 2012 Mar;46(3):397-406. Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells. Am J Respir Crit Care Med. 2011;183(1):31-42. Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents: double blind, randomised and placebo controlled trial. BMJ. 2010 Mar 8;340:c1004. PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009;296(6):L959-69. NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract. Respir Res. 2008;9:66. A prospective comparison of nursing home-acquired pneumonia with hospital-acquired pneumonia in non-intubated elderly. Respir Med. 2008;102(9):1287-95. Prostacyclin analogs stimulate VEGF production from human lung fibroblasts in culture. Am J Physiol Lung Cell Mol Physiol. 2008;294(6):L1226-32. . Role of thrombin in interleukin-5 expression from basophils. Biochem Biophys Res Commun. 2008;368(1):116-20. Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor. Am J Respir Cell Mol Biol. 2008;39(3):356-63. PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. Biochem Biophys Res Commun. 2008;369(4):1199-203. The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6. Am J Respir Cell Mol Biol. 2007;37(1):121-8. Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway. Am J Respir Cell Mol Biol. 2007;37(1):113-20. Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradation. Am J Respir Cell Mol Biol. 2006;35(6):714-21. Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure. Proc Natl Acad Sci U S A. 2006;103(24):9250-5. Reactive nitrogen species augment fibroblast-mediated collagen gel contraction, mediator production, and chemotaxis. Am J Respir Cell Mol Biol. 2006;34(5):592-9. Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblasts. Biochem Biophys Res Commun. 2006;339(1):290-5. TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels. Respir Res. 2005 Dec 2;6:141. Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2005 Aug;33(2):121-9. Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts. Biochem Biophys Res Commun. 2005 Feb 11;327(2):393-8. Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon. Eur Respir J. 2004 Dec;24(6):918-24. Cells derived from the circulation contribute to the repair of lung injury. Am J Respir Crit Care Med. 2004 Dec 1;170(11):1158-63. Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts. Am J Respir Cell Mol Biol. 2004 Nov;31(5):483-90. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads. Am J Respir Cell Mol Biol. 2004 Jun;30(6):816-22. TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids. J Allergy Clin Immunol. 2003 Jun;111(6):1307-18. Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction. Am J Respir Cell Mol Biol. 2003 Jan;28(1):111-21. Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase. Am J Respir Cell Mol Biol. 2002 Oct;27(4):487-94. PGD(2) modulates fibroblast-mediated native collagen gel contraction. Am J Respir Cell Mol Biol. 2002 Sep;27(3):375-81. Prostacyclin analogs inhibit fibroblast migration. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L428-32. Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L409-17. Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma. Am J Respir Cell Mol Biol. 2002 Apr;26(4):484-90. Long-term inhalation of high-dose nitric oxide increases intraalveolar activation of coagulation system in mice. Am J Respir Crit Care Med. 2001 Jun;163(7):1676-82. Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse. Am J Respir Crit Care Med. 2001 Jun;163(7):1660-8. Type I collagen metabolites as tumor markers in patients with lung carcinoma. Cancer. 1999 May 1;85(9):1951-7. Protein C anticoagulant system in patients with interstitial lung disease. Am J Respir Crit Care Med. 1998 Jun;157:1850-4. Arterial endothelin-1 level in pulmonary emphysema and interstitial lung disease. Relation with pulmonary hypertension during exercise. Eur Respir J. 1997 Sep;10(9):2055-60. The effect of low-dose inhalation of nitric oxide in patients with pulmonary fibrosis. Eur Respir J. 1997 Sep;10(9):2051-4. Prognostic significance of plasma D-dimer levels in patients with lung cancer. Thorax. 1997 Jun;52(6):563-5. Combined inhalation of nitric oxide and oxygen in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1997 Feb;155(2):526-9. |
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