職名 講師
氏名 さわだ ひろふみ
澤田 博文
生年月 1968.05
所属 部局 医学系研究科
学科・専攻 生命医科学専攻
講座 臨床医学系講座
教育研究分野  
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学歴  
学位 2007.09 医学博士 三重大学
所属学会 日本小児科学会, 日本小児循環器学会, 日本循環器学会, 日本周産期新生児医学会, 日本新生児成育医学会, 日本肺高血圧肺循環学会、日本川崎病学会、日本小児保健協会、 American Heart Association, American Thoracic Society
社会活動  
職歴 1993.05~1993.06 三重大学医学部付属病院 研修医
1993.07~1994.01 国立津病院 小児科研修医
1994.01~1994.06 国立三重病院 小児科研修医
1994.07~1995.06 三重大学医学部付属病院 医員
1995.07~1996.04 三重県立総合医療センター 専門診療医
1996.05~1999.04 国立循環器病センター レジデント
1999.05~1999.06 三重大学医学部付属病院 医員
1999.07~2002.06 国立三重中央医療センター 医師
2002.07~2003.03 三重大学医学部付属病院 医員
2003.04~2005.06 三重大学医学部付属病院 助手
2005.07~2006.06 尾鷲総合病院 医長
2006.07~2007.08 山田赤十字病院 副部長
2007.08~2010.09 スタンフォード大学 ポストドクトラルフェロー
2010.10~2014.01 三重大学大学院医学系研究科 助教
学術(芸術)賞  
専門分野 小児科学、小児循環器学、新生児学、血管生物学、肺高血圧
現在の研究課題  
担当科目 教養教育:Medical English、小児の疾患と障害-子どもの命を守るために- 
医学部:小児循環器学 小児後天性心疾患
主な業績等 1. Sawada H, Tsuda E, Ono Y, Arakaki Y, Echigo S, Kamiya T, Kida K, Umemoto M, Miyahara M, Kawaguchi H. Two cases with severe mitral regurgitation due to ruptured chordae tendineae with Kawasaki disease. (Japanese). Progress in Medicine, 17: 1729-34 1997
2. Azuma E, Kojima S, Kato K, Matsuyama T, Yamada Y, Kondo N, Sawada H, Hanada M, Shibata T, Tabata N, Watanabe M, Shimono Y, Deguchi T, Umemoto M, Higashikawa M, Kawasaki H, Komada Y, Sakurai M. Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia. Bone Marrow Transplant, 19:1085-7 1997
3. Sawada H, Echigo S, Ono Y, Arakaki, Tsukano S, Ohuchi H, Kamiya T, Stent implantation for the coarctation of aorta in a pediatric patient with severe cardiac dysfunction. (Japanese). 日本小児循環器学会雑誌, 16:85-91 2000
4. Wakutani Y, Nakayasu H, Takeshima T, Adachi M, Kawataki M, Kihira K, Sawada H, Bonno M, Yamamoto H, Nakashima K. Mutational analysis of carbamoylphosphate synthetase I deficiency in three Japanese patients. J Inherit Metab Dis., 27:787-8. 2004
5. Mitani Y, Sawada H, Hayakawa H, Aoki K, Ohashi H, Matsumura M, Kuroe K, Shimpo H, Nakano M, Komada Y. Elevated levels of high-sensitivity C-reactive protein and serum amyloid-A late after Kawasaki disease: association between inflammation and late coronary sequelae in Kawasaki disease. Circulation. 111:38-43 2005
6. Ashida Y, Miyahara H, Sawada H, Mitani Y, Maruyama K. Anesthetic management of a neonate with vein of Galen aneurysmal malformations and severe pulmonary hypertension. Paediatr Anaesth. 215:525-8. 2005
7. Takabayashi S, Ito H, Shimpo H, Sawada H, Mitani Y, Komada Y. Emergent permanent pacemaker implantation in a premature 1,502 g neonate. Jpn J Thorac Cardiovasc Surg. 53:176-9. 2005
8. Takabayashi S, Shimpo H, Miyake Y, Onoda K, Sawada H, Mitani Y. Performance of the Fontan procedure using extra-cardiac direct anastomosis on patients treated for penicillin-resistant Streptococcus pneumoniae endocarditis. Jpn J Thorac Cardiovasc Surg. 53:176-9. 2005
9. Sawada H, Mitani Y, Ohashi H, Hayakawa H, Ikeyama Y, Takabayashi S, Shimpo H, Maruyama K, Komada Y. Reversal of increased pulmonary arterial pressure associated with systemic venous collaterals after tonsillectomy in a Fontan candidate after Glenn procedure: Impact of obstructive sleep apnea on Fontan circulation. J Thorac Cardiovasc Surg. 133: 1371-3 2007
10. Mitani Y, Takabayashi S, Sawada H, Ohashi H, Hayakawa H, Ikeyama Y, Imanaka-Yoshida K, Maruyama K, Shimpo H, Komada Y. Fate of the ‘opened’ arterial duct: Lessons learned from bilateral pulmonary artery banding for hypoplastic left heart syndrome under the continuous infusion of prostaglandin E1. J Thorac Cardiovasc Surg. 133: 1653-4 2007
11. Sawada H, Mitani Y, Maruyama J, Jiang BH, Ikeyama Y, Dida FA, Yamamoto H, Imanaka-Yoshida K, Shimpo H, Mizoguchi A, Maruyama K, Komada Y A nuclear factor-kB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats. Chest. 132: 1265-74. 2007
12. Mitani Y, Maruyama J, Jiang BH, Sawada H, Shimpo H, Imanaka-Yoshida K, Kaneda Y, Komada Y, Maruyama K. ANP gene transfection with a novel envelope vector system ameliorates pulmonary hypertension in rats. J Thorac Cardiovasc Surg. 136:142-9,2008
13. Kamada N, Mitani Y, Kihira K, Iwao A, Sinoki T, Ikeyama Y, Sawada H, Deguchi T, Takabayashi S, Shimpo H, Komada Y. Images in cardiovascular medicine. Fatal pulmonary lymphangiectasia manifesting after repeated surgeries for intractable chylopericardium and chylothorax in a 20-month-old girl. Circulation. 117:1894-6 2008
14. Iwasa T, Mitani Y, Sawada H, Takabayashi S, Shimpo H, Matsubayashi N, Komada Y. Persistent lung shadow in an infant with ventricular septal defect and partial anomalous pulmonary venous connection associated with pulmonary venous obstruction. Pediatr Int. 50:397-9 2008
15. Mitani Y, Ohashi H, Sawada H, Ikeyama Y, Hayakawa H, Takabayashi S, Maruyama K, Shimpo H, Komada Y. In Vivo Plaque Composition and Morphology in Coronary Artery Lesions in Adolescents and Young Adults Long After Kawasaki Disease. A Virtual Histology-Intravascular Ultrasound Study. Circulation. 119: 2829-36 2009
16. Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M. Tie2-Mediated Loss of Peroxisome Proliferator-Activated Receptor-{gamma} in Mice Causes PDGF-Receptor{beta}-Dependant Pulmonary Arterial Muscularization. Am J Physiol Lung Cell Mol Physiol. 297: L1082-90 2009
17. Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M. BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol. 192(1):171-88 2011
18. Lee SJ, Smith A, Guo L, Alastalo TP, Li M, Sawada H, Liu X, Chen ZH, Ifedigbo E, Jin Y, Feghali-Bostwick C, Ryter SW, Kim HP, Rabinovitch M, Choi AM. Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 183(5):649-58 2011
19. Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira C, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M. Neutrophil Elastase is Produced by Pulmonary Artery Smooth Muscle Cells and is Linked to Neointimal Lesions. American Journal of Pathology, 179:1560-72 2011
20. Alastalo TP, Li M, Perez VA, Pham D, Sawada H, Wang JK, Koskenvuo M, Wang L, Chang HY, Marlene Rabinovitch. One Morphogenetic Protein Induces a PPARgamma-betaCatenin Transcription Factor Complex Targeting Apelin to Prevent Pulmonary Hypertension. J Clin Invest, 121: 3735-46 2011
21. Razavi H, Zarafshar SY, Sawada H, Taylor CA, Feinstein JA. Quantitative characterization of postnatal growth trends in proximal pulmonary arteries in rats by phase-contrast magnetic resonance imaging. Am J Physiol Lung Cell Mol Physiol. 301: L368-79 2011
22. de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M. Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans. Circ Res. 11:1551-64 2012
23. Razavi H, Stewart SE, Xu C, Sawada H, Zarafshar SY, Taylor CA, Rabinovitch M, Feinstein JA. Chronic effects of pulmonary artery stenosis on hemodynamic and structural development of the lungs. Am J Physiol Lung Cell Mol Physiol. 304: L17-28 2013
24. Mitani Y, Ohta K, Yodoya N, Otsuki S, Ohashi H, Sawada H, Nagashima M, Sumitomo N, Komada Y. Public access defibrillation improved the outcome after out-of-hospital cardiac arrest in school-age children: a nationwide, population-based, Utstein registry study in Japan. Europace. 15:1259-66 2013
25. Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest. 123:3600-13. 2013
26. Sawada H, Saito T, Nickel NP, Alastalo TP, Glotzbach JP, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai YJ, Perez Vde J, Kim YM, Wang L, Chen PI, Spiekerkoetter E, Mitani Y, Gurtner GC, Sarnow P, Rabinovitch M. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med, 211:263-80 2014
27. Yamada Y, Maruyama J, Zhang E, Okada A, Yokochi A, Sawada H, Mitani Y, Hayashi T, Suzuki K, Maruyama K. Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension. J Anesth. 28:26-33. 2014
28. Iwasa T, Ohashi H, Kihira K, Koike Y, Otake K, Inoue M, Sawada H, Toyoda H, Komada Y. 10-year-old girl with life-threatening idiopathic systemic capillary leak syndrome: a case report. BMC Pediatr. 14:137 2014
29. Iwashita Y, Zhang E, Maruyama J , Yokochi A, Yamada Y, Sawada H, Mitani Y, Imai H, Suzuki K, Maruyama K. Thrombomodulin protects against lung damage created by high level of oxygen with large tidal volume mechanical ventilation in rats. Journal of Intensive Care. 2:57 2014
30. Shinohara T, Sawada H, Otsuki S, Yodoya N, Kato T, Ohashi H, Zhang E, SaitohS, Shimpo H, Maruyama K, Komada Y, Mitani Y. Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis. Am J Physiol Lung Cell Mol Physiol.2015 Mar 15;308(6): L523-38. doi: 10.1152/ajplung.00129.2014. Epub 2014 Dec 24. PubMed PMID: 25539851.
31. Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Imanaka-Yoshida K, Shimpo H, Maruyama K, Komada Y, Mitani Y. Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats. PLoS One. 2015 Feb 25;10(2):e0118655. doi: 10.1371/journal.pone.0118655. eCollection 2015. PubMed PMID: 25714834; PubMed Central PMCID: PMC4340876.
32. Zhang E, Maruyama J, Yokochi A, Mitani Y, Sawada H, Nishikawa M, Ma N, Maruyama K. Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. J Anesth. 2015 Oct;29(5):715-23. doi: 10.1007/s00540-015-2015-y. Epub 2015 May 1. PubMed PMID: 25931318.
33. Yaoita M, Niihori T, Mizuno S, Okamoto N, Hayashi S, Watanabe A, Yokozawa M, Suzumura H, Nakahara A, Nakano Y, Hokosaki T, Ohmori A, Sawada H, Migita O, Mima A, Lapunzina P, Santos-Simarro F, Garcテュa-Miテアaテコr S, Ogata T, Kawame H, Kurosawa K, Ohashi H, Inoue S, Matsubara Y, Kure S, Aoki Y. Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. Hum Genet. 2016 Feb;135(2):209-22. doi: 10.1007/s00439-015-1627-5. Epub 2015 Dec 29. PubMed PMID: 26714497.
34. Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP. Loss of PPAR in endothelial cells leads to impaired angiogenesis. J Cell Sci. 2016 Feb 15;129(4):693-705. doi: 10.1242/jcs.169011. Epub 2016 Jan 7. PubMed PMID: 26743080.
35. Nishimura Y, Sasagawa S, Sawada H, ZhangE, Murakami S, Ashikawa Y, Yuge M, Okabe S, Kawaguchi K, Kawase R, Mitani Y, Maruyama K, TANAKA T. Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension. Front. Pharmacol., 07 June 2016. | http://dx.doi.org/10.3389/fphar.2016.00142
36. Clinical factors associated with in-hospital death in pediatric surgical patients admitted to the neonatal intensive care unit: a 15-year single tertiary center experience.
Otake K, Uchida K, Kubo M, Yamamoto A, Nagano Y, Uratani R, Hashimoto K, Matsushita K, Inoue M, Sawada H, Kusunoki M.
J Pediatr Surg. 2018 Mar;53(3):499-502.
37. Sumitomo N, Baba R, Doi S, Higaki T, Horigome H, Ichida F, Ishikawa H, Iwamoto M, Izumida N, Kasamaki Y, Kuga K, Mitani Y, Musha H, Nakanishi T, Yoshinaga M, Abe K, Ayusawa M, Hokosaki T, Kato T, Kato Y, Ohta K, Sawada H, Ushinohama H, Yoshiba S, Atarashi H, Hirayama A, Horie M, Nagashima M, Niwa K, Ogawa S, Okumura K, Tsutsui H; Japanese Circulation Society and the Japanese Society of Pediatric Cardiology and Cardiac Surgery of Joint Working.Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) - Digest Version. Circ J. 2018 Aug 24;82(9):2385-2444. doi: 10.1253/circj. CJ-66-0153. Epub 2018 Aug 11.
38. Sawada H, Mitani Y, Nakayama T, Fukushima H, Kogaki S, Igarashi T, Ichida F, Ono Y, Nakanishi T, Doi S, Ishikawa S, Matsushima M, Yamada O, Saji T. Detection of Pediatric Pulmonary Arterial Hypertension by School Electrocardiography Mass Screening
Am J Respir Crit Care Med. 2019 Jun1; 199(11): 1397-1406. doi: 10.1164/rccm.201802-0375OC.

図書
(1)澤田博文、駒田美弘、 脈管系の良性腫瘍
ネルソン小児科学、17版(エルゼビアジャパン)1751-2 2005

(2)澤田博文、三谷義英、 心内膜炎
小児科診断治療指針(中山書店)2012年、630-5 2012

(3)Maruyama J, Yokochi A, Zhang E, Sawada H, Maruyama K Chapter4 Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension
Pulmonary Hypertension (INTECH)ISBN 978-953-51-1165-8

(4)澤田博文、三谷義英、 ガス療法の使い方 小児科診療(診断と治療社)2016年 7巻 共著146 (p103-109)

(5)澤田博文、 Eisenmenger 症候群
今日の小児治療指針第16版(医学書院)2015年 共著1006 (p511-513)

(6)澤田博文、大橋啓之、三谷義英、 心疾患に合併する睡眠障害、日常診療における子どもの睡眠障害(診断と治療社)2015年 共著243 (p103-107)

(7)澤田博文、三谷義英、 小児循環器領域における薬物療法 特殊性と治療の実際 医学のあゆみ 循環器薬物療法UPDATE(医歯薬出版株式会社)2016年 259巻、14号 共著146 (p1365-70)

(8)澤田博文、総説 肺高血圧領域における実験的動物モデルの利用:得られた知見と課題
血管2017 Vol 40, No4, 145-159

(9)澤田博文、三谷義英、 新生児遷延性肺高血圧 基礎知識、循環器診療 ザ・ベーシック 肺高血圧症(株式会社メジカルビュー社)2018年3月20日 共著171 (p100-107)

(10)澤田博文、三谷義英、 新生児遷延性肺高血圧 実践、循環器診療 ザ・ベーシック 肺高血圧症(株式会社メジカルビュー社)2018年3月20日 共著171 (p108-115)

(11)澤田博文、 手術をした先天性心疾患の児童・生徒に対する管理指導について教えてください 学校検診実践マニュアルQ&A 日本小児循環器学会編 (診断と治療社) 2018年7月12日 共著 (p)

(12)澤田博文、 日本循環器学会 学校検診ガイドライン

(13)白石淳、今西洋介、豊島勝昭、佐藤義明、北村創矢、加藤太一、澤田博文
「新生児肺高血圧の遠隔期治療」 新生児成育学会雑誌2019年

(14)澤田博文 <総説> 肺高血圧の基礎研究:小児肺高血圧に関連の深い実験モデル:
- 肺動脈性肺高血圧・気管支肺異形成・先天性横隔膜ヘルニア –
小児循環器学会雑誌35(2): 99-111, 2019 

(15)Maruyama K, Maruyama J, Sawada H. Endogenous and Inhaled Nitric Oxide for the Treatment of Pulmonary Hypertension. IntechOpen
DOI: 10.5772/intechopen.89381