| 教員紹介トップページへ | 三重大学トップページへ |
| 職名 | 准教授 | |||||||||
| 氏名 | パク ウンゾン 朴 恩正 |
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| 生年月 | 1967.11 | |||||||||
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| TEL | 059-231-6408 | |||||||||
| FAX | 059-231-5209 | |||||||||
| epark@med. (末尾に mie-u.ac.jp を補ってください) | ||||||||||
| 個人のホームページ | https://www.medic.mie-u.ac.jp/molpath/staff/page2.html | |||||||||
| 学歴 | 1993 成均館大学校卒業 (学士)
1995 同大学大学院卒業 (修士) |
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| 学位 | 2004 医学博士 大阪大学大学院医学系研究科
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| 所属学会 | 日本免疫学会
日本血栓止血学会 日本ショック学会 |
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| 社会活動 | ||||||||||
| 職歴 | 1994.12-1999 財団法人牧岩生命工学研究所 主任研究員
2004-2009 ハーバード大学医学部 博士研究員 2009-2011 同大学医学部 インストラクター 2012-2014 東京大学医科学研究所 特任助教 2014.10-現在 三重大学大学院医学系研究科 准教授 |
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| 学術（芸術）賞 | 2008 GSK-IDI Research Fellowship Award
2013 飯島記念食品科学振興財団 学術研究助成 2016 三重県健康管理事業センター がん研究助成 2019 三重大学医学部・医学系研究科 教育貢献賞 |
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| 専門分野 | 粘膜免疫学
分子病態学 |
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| 現在の研究課題 | 白血球に由来する細胞外小胞による粘膜免疫組織内の微小環境リモデリングの分子機構の探求
老化に伴う腸管上皮バリア機能障害の分子基盤の解明 炎症免疫疾患の誘導や制御の分子病態学的理解 |
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| 担当科目 | 分子医学実習
分子病態学 分子生命医学 生命医科学特論 |
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| 主な業績等 | Kim JH, Park EJ, Lee TK, Lee WS. Genomic sequences of the soybean 24 kDa oleosin genes and initial analysis of their promoter sequences. Molecules and Cells. 1996, 6:393-399
Won J, Kim H, Park EJ, Hong Y, Kim SJ, Yun Y. Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor-beta receptor therapy. Cancer Research. 1999, 59:1273-1277. Park EJ, Chang JH, Kim JS, Chung SI, Yum JS. Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin. Experimental & Molecular Medicine. 1999, 31:101-107 Park EJ, Chang JH, Kim JS, Yum JS, Chung SI. The mucosal adjuvanticity of two nontoxic mutants of Escherichia coli heat-labile enterotoxin varies with immunization routes. Experimental & Molecular Medicine. 2000, 32:72-78 Kim JS, Chang JH, Park EJ, Chung SI, Yum JS. Evaluation of factors that can affect protective immune responses following oral immunization of recombinant Helicobacter pylori urease apoenzyme. Journal of Microbiology and Biotechnology. 2000, 10:865-872 Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, Kiyono H. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. Journal of Immunology. 2002, 169(11):6187-6192 Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki JI, Kiyono H. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. Journal of Immunology. 2003, 171(8):4131-4139 Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. Journal of Immunology. 2004, 73(5):3337-3347 Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, Kiyono H. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. Journal of Immunology. 2005, 174(7):4365-4372 Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H. Cutting Edge: Uniqueness of lymphoid chemokine receptor requirement for the initiation and maturation of NALT organogenesis. Journal of Immunology. 2006, 177(7):4276-4280 Park EJ, Mora JR, Carman CV, Chen JF, Sasaki Y, Cheng G, von Andrian UH, Shimaoka M. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. Journal of Clinical Investigation. 2007, 117(9):2526-2538 Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA targeting revealing cyclin D1 as an anti-inflammatory target. Science. 2008, 319(5863):627-630 Shimaoka M, Park EJ. Advances in understanding sepsis. European Journal of Anaesthesiology Suppl. 2008, 25:146-153 Imai Y*, Park EJ*, Peer D, Peixoto A, Cheng G, von Andrian UH, Carman CV, Shimaoka M. Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha4 integrins. Blood. 2008, 112(13):5007-5015 Park EJ, Shimaoka M. Activation of Leukocyte Integrins. Leukocyte Adhesion in Current Topics in Membranes (Klaus Ley). 2009, 64:115-132 Park EJ*, Peixoto A*, Imai Y, Goodarzi A, Cheng G, Carman CV, von Andrian UH, Shimaoka M. Distinct roles for LFA-1 affinity regulation during T cell adhesion, diapedesis, and interstitial migration in lymph nodes . Blood. 2010, 115(8):1572-1581 Dearling JL, Park EJ, Dunning P, Baker A, Fahey F, Treves ST, Soriano SG, Shimaoka M, Packard AB, Peer D. Detection of intestinal inflammation by microPET imaging using a 64Cu-labeled anti-beta7 integrin antibody. Inflammatory Bowel Disease. 2010, 16(9):1458-1466 Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. A rice-based soluble form of a TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. Journal of Biotechnology. 2014, 175:45-52. Park EJ#, Yuki Y, Kiyono H, Shimaoka M. Structural basis of blocking integrin activation and deactivation for anti-inflammation. Journal of Biomedical Science. 2015, 22:51 Fukuyama Y, Yuki Y, Katakai Y, Harada N, Takahashi H, Takeda S, Mejima M, Joo S, Kurokawa S, Sawada S, Shibata H, Park EJ, Fujihashi K, Briles DE, Tsukada H, Yasutomi Y, Tsukada H, Akiyoshi K, Kiyono H. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunology. 2015, 8(5):1144-1153 Lee J*, Park EJ*, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Scientific Reports. 2015, 5:18174 Lee J, Park EJ, Kiyono H. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. BMB Reports. 2016, 49(5):263-269 Park EJ, Shimaoka M, Kiyono H. MicroRNA-mediated dynamic control of mucosal immunity. International Immunology. 2017, 29(4):157-163 Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunology. 2017, 10(4):901-911 Okamoto T, Kawamoto E, Takagi Y, Akita N, Hayashi T, Park EJ, Suzuki K, Shimaoka M. Gap junction-mediated regulation of endothelial cellular stiffness. Scientific Reports. 2017, 7(1):6134 Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H. Development of immune and microbial environment is independently regulated in the mammary gland. Mucosal Immunology. 2018, 11(3):643-653 Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Science Translational Medicine. 2018, 10(429). pii: eaan0333 Okamoto T, Takagi Y, Kawamoto E, Park EJ, Usuda H, Wada K, Shimaoka M. Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor-g expression. Experimental Cell Research. 2018, 367(2):264-273 Park EJ*,#, Prajuabjinda O*, Soe ZY, Darkwah S, Appiah MG, Kawamoto E, Momose F, Shiku H, Shimaoka M#. Exosomal regulation of lymphocyte homing to the gut. Blood Advances. 2019, 3(1):1-11 Shimaoka M, Kawamoto E, Gaowa A, Okamoto T, Park EJ. Connexins and Integrins in Exosomes. Cancers (Basel). 2019, 11(1). pii: E106 Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui-Ito A, Sakakura Y, Akama Y, Soe ZY, Prajuabjinda O, Darkwah S, Appiah MG, Myint PK, Obeng G, Park EJ, Imai H, Shimaoka M. Anti-adhesive effects of human soluble thrombomodulin and its domains. Biochemical and Biophysical Research Communications. 2019, 511(2):312-317 Soe ZY, Prajuabjinda O, Myint PK, Gaowa A, Kawamoto E, Park EJ#, Shimaoka M#. Talin-2 regulates integrin functions in exosomes . Biochemical and Biophysical Research Communications. 2019, 512(3):429-434 Kawamoto E, Masui-Ito A, Eguchi A, Soe ZY, Prajuabjinda O, Darkwah S, Park EJ, Imai H, Shimaoka M. Integrin and PD-1 ligand expression on circulating extracellular vesicles in systemic inflammatory response syndrome and sepsis. Shock. 2019, 52(1):13-22 Samuel D, Nago N, Appiah MG, Myint PK, Kawamoto E, Shimaoka M, Park EJ#. Differential roles of dendritic cells in expanding CD4 T cells in sepsis. Biomedicines. 2019, 7(3):52 Park EJ#, Appiah MG, Myint PK, Gaowa A, Kawamoto E, Shimaoka M#. Exosomes in Sepsis and Inflammatory Tissue Injury. Current Pharmaceutical Design. 2019, 25(42):4486-4495 Park EJ, Kawamoto E, Shimaoka M. Mucosal Immunity for Inflammation: Regulation of gut-specific lymphocyte migration by integrins. Mucosal Vaccines (Hiroshi Kiyono): Innovation for Preventing Infectious Diseases. 2nd Edition. 2020, 85-99 Nago N, Yoneda M, Darkwah S, Kawamoto E, Park EJ, Shimaoka M. Micro-MRI-based detection of tissue damage in the liver, pancreas, and kidney during the early phases of an LPS and D-galactosamine-induced hepatic injury model in mice. Diagnostic Pathology Open. 2020, 5(1):161 Myint PK, Park EJ, Gaowa A, Kawamoto E, Shimaoka M. Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins. Diagnostic Pathology. 2020, 15(1):38 Park EJ, Darkwah S, Appiah MG, Shimaoka M, Kiyono H. The mucosal immune system as a control mechanism of septic shock. Shock (JSS). 2020, 34(2):44-64 Prajuabjinda O, Soe ZY, Park EJ#. Integrin-mediated tissue-specific homing of lymphocytes and exosomes to the gut. Shock (JSS). 2020, 34(2):37-42 Yan Q, Gaowa A, Kawamoto E, Park EJ, Shimaoka. Intestinal epithelial organoids: A platform for discovering mucosal healing drug candidates for the treatment of IBDs. Diagnostic Pathology Open. 2020, 5(2):166 Akama Y, Satoh-Takayama N, Kawamoto E, Ito A, Gaowa A, Park EJ, Imai H, Shimaoka M. The role of innate lymphoid cells in the regulation of immune homeostasis in sepsis-mediated lung inflammation. Diagnostics (Basel). 2020, 10(10):808 Park EJ#, Myint PK, Ito A, Samuel D, Appiah MG, Kawamoto E, Shimaoka M#. Integrin-irisin interactions in health and diseases. Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights into the Multifaceted Roles of an Emerging Ligand Irisin. Frontiers in Cell and Developmental Biology. 2020, 8:588066 Appiah MG*, Park EJ*,#, Samuel D, Kawamoto E, Akama Y, Gaowa A, Kalsan M, Ahmad, S, Shimaoka M#. Intestinal Epithelium-Derived Luminally Released Extracellular Vesicles in Sepsis Exhibit the Ability to Suppress TNF-a and IL-17A Expression in Mucosal Inflammation. International Journal of Molecular Sciences. 2020, 21:8445 Kawamoto E, Park EJ, Shimaoka M. Methods to study integrin functions on exosomes. Methods in Molecular Biology. 2021, 2217:265-281 Darkwah S, Park EJ, Myint PK, Ito A, Appiah MG, Obeng G, Kawamoto E, Shimaoka M. Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Tumor Microenvironment. Frontiers in Cell and Developmental Biology. 2021, 9:634853 Nakamori Y, Park EJ, Shimaoka M. Immune deregulation in sepsis and septic shock: reversing immune paralysis by targeting PD-1/PD-L1 pathway. Frontiers in Immunology. 2021, 11:624279 Park EJ*,#, Myint PK*, Appiah MG, Worawattananutai P, Inprasit J, Prajuabjinda O, Soe ZY, Gaowa A, Kawamoto E, Shimaoka M#. Ligand-competent fractalkine receptor is expressed on exosomes. Biochemistry and Biophysics Reports. 2021, 26:100932 Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui-Ito A, Akama Y, Darkwah S, Appiah MG, Myint PK, Obeng G, Ito A, Caidengbate S, Esumi R, Yamaguchi T, Park EJ, Imai H, Shimaoka M. The lectin-like domain of thrombomodulin inhibits β1 integrin-dependent binding of human breast cancer-derived cell lines to fibronectin. Biomedicines. 2021. 9(2):162 Yamaguchi T, Kawamoto E, Gaowa A, Park EJ, Shimaoka M. Remodeling of bone marrow niches and roles of exosomes in leukemia. International Journal of Molecular Sciences. 2021, 22:1881 Soe ZY, Park EJ, Shimaoka M. Integrin Regulation in Immunological and Cancerous Cells and Exosomes. International Journal of Molecular Sciences. 2021, 22:2193 Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto E, Darkwah S, Appiah MG, Myint PK, Imai H, Shimaoka M. Sepsis induces dysregulation of IL-13 production and PD-1 expression in lung group 2 innate lymphoid cells. Shock. 2021, 55(3):357-370 Myint PK, Ito A, Appiah MG, Obeng G, Darkwah S, Kawamoto E, Gaowa A, Park EJ, Shimaoka M. Irisin supports integrin-mediated cell adhesion of lymphocytes. Biochemistry and Biophysics Reports. 2021, 26:100977. Lee J, Mohsen A, Banerjee A, McCullough LD, Mizuguchi K, Shimaoka M, Kiyono H, Park EJ#. Distinct age-specific miRegulome profiling of isolated small and large intestinal epithelial cells in mice. International Journal of Molecular Sciences. 2021, 22:3544 Park EJ#, Myint PK, Appiah MG, Darkwah S, Caidengbate S, Ito A, Matsuo E, Kawamoto E, Gaowa A, Shimaoka M#. The spike glycoprotein of SARS-CoV-2 binds to β1 integrins expressed on the surface of lung epithelial cells. Viruses. 2021, 13:645 Okamoto T*, Park EJ*, Kawamoto E, Usuda H, Wada K, Taguchi A, Shimaoka M. Endothelial Connexin-Integrin Crosstalk in Vascular Inflammation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2021, 166168 和文総説、書籍、特許等 高橋 一郎、朴 恩正、清野 宏. 粘膜免疫担当組織細胞の特殊性と炎症性腸疾患. Molecular Medicine. 2002, 39(9):1000-1007 Chang J, Kim JS, Park EJ, Yum JS, Chung SI. Angiogenesis Inhibitor. 2004, US6743428B1 Chang J, Kim JS, Park EJ, Yum JS, Chung SI. Novel Angiogenesis Inhibitor. 2005, CN1189482C Chang J, Kim JS, Park EJ, Yum JS, Chung SI. 新規血管形成阻害剤. 2005, JP3725473B2 Chang J, Kim JS, Park EJ, Yum JS, Chung SI. Nucleic Acid Encoding Angiogenesis inhibitor. 2006, US7118905B2 Park EJ, Kim JS, Chang J, Yum JS, Chung SI. Detoxified mutants of Escherichia coli heat-labile enterotoxin. 2010, US7722887B1 朴 恩正. MucoRice-CTBコメ型経口ワクチンにおける記憶免疫誘導の研究. 年報/飯島藤十郎記念食品科学振興財団編 (ISSN: 2188-0662). 2013, 29:144-148 朴 恩正. 抗老化に向けた腸管上皮細胞と細胞外小胞のマイクロRNA遺伝子情報データベース構築. アレルギーの臨床 (ISSN: 0285-6379). 2016, 36(13):1278-1280 島岡 要、長太 のどか、川本 英嗣、朴 恩正. インテグリン活性化と炎症制御. Shock (ISSN: 0919-8156). 2018, 32(2):48-51 島岡 要、朴 恩正、川本 英嗣、阿栄 高娃. エキソソーム・インテグリン：機能制御と疾患との関連. 日本血栓止血誌 (ISSN: 1880-8808). 2019, 30(4):596-602 阿栄 高娃、朴 恩正、島岡 要. 腸管上皮幹細胞の増殖促進及び上皮分化誘導に着目した粘膜治癒の新規治療法の開発に向けて. アレルギーの臨床 (ISSN: 0285-6379). 2019, 39(14):1055-1058 阿栄 高娃、朴 恩正、島岡 要. 腸管上皮再生を目指した新規治療法の開発. アレルギーの臨床 (ISSN: 0285-6379). 2020, 40(8):658-661 阿栄 高娃、秦 艶、朴 恩正、島岡 要. 腸上皮オルガノイドを用いた炎症性腸疾患の病態解明と治療展望. Medical Science Digest (ISSN: 1347-4340). 2020, 46(7):410-412 阿栄 高娃、Appiah MG、朴 恩正、島岡 要. 腸管上皮由来エキソソームがキャリアーするマイクロRNAによる炎症性サイトカインの発現抑制. アレルギーの臨床 (ISSN: 0285-6379). 2021, 41(2):181-184 長太 のどか、川本 英嗣、朴 恩正、島岡 要. リコモジュリンによる白血球インテグリンと 血管内皮細胞上のインテグリンリガンドを介した接着制御作用. 鈴鹿医療科学大学紀要. 2021, 27:41-54 川本 英嗣、中森 裕毅、朴 恩正、島岡 要. ヒトトロンボモジュリンの新たな抗炎症作用 -白血球インテグリンと相互作用-. 炎症と免疫 (ISSN: 0918-8371). 2021, 29(3):74-81 |
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