職名 准教授
氏名 おおいしこうし
大石晃嗣
生年月 1961.05
所属 部局 附属病院
学科・専攻 輸血・細胞治療部
講座  
教育研究分野  
TEL  
FAX  
E-mail koishi@clin.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ  
学歴 金沢大学医学部 学士課程 (~1988年03月)
学位 1996.03 医学博士 三重大学
所属学会 日本内科学会 日本血液学会 日本造血細胞移植学会 アメリカ血液学会 日本癌学会 日本輸血細胞治療学会 エイズ学会 日本医学検査学会 欧州血液学会
社会活動 医療法人社団 岡波総合病院,非常勤医師
医療法人社団主体会 主体会病院
医療法人社団主体会 小山田記念温泉病院
財団法人骨髄移植推進財団,調整医師
日本輸血・細胞治療学会 東海支部
職歴 1988.06~1989.08 三重大学医学部附属病院 医員・研修医
1989.09~1991.08 厚生連松阪中央総合病院内科 研修医
1991.09~1998.03 三重大学医学部附属病院 医員
1998.04~2002.04 Fred Hutchinson 癌センター Research associate
2002.05~2002.09 三重大学医学部附属病院 医員
2002.11~2006.10 宮川医療少年院 医務課長
2006.11~2007.03 三重刑務所 医務課長
2007.04~2007.10 三重大学大学院医学系研究科造血病態内科学 助教
2007.08~2007.10 三重大学医学部附属病院血液内科 助教
2007.11~2013.08 三重大学医学部附属病院輸血部 講師 部長
2013.09~2017.03 三重大学医学部附属病院輸血部 准教授 美朝
2017.04~ 三重大学医学部附属病院輸血・細胞治療部 病院教授 部長
学術(芸術)賞  
専門分野  
現在の研究課題 リンパ球/樹状細胞分化と腫瘍化のメカニズムの解明
担当科目 骨髄増殖性腫瘍、慢性骨髄性白血病、造血不全、HIV感染症、 輸血
主な業績等 The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis. 共著 2017.01 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 1076029617736382-
Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis. 共著 2018.01 International journal of hematology 107 92-97
Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study. 共著 2018.02 International journal of hematology 107 185-193
An Evaluation of the Activated Partial Thromboplastin Time Waveform. 共著 2017.01 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 1076029617724230-
Monitoring of hemostatic abnormalities in major orthopedic surgery patients treated with edoxaban by APTT waveform. 共著 2018.02 International journal of laboratory hematology 40 49-55
CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation. 共著 2017.10 Journal of immunology (Baltimore, Md. : 1950) 199 2343-2355
Isolated thrombocytosis in chronic myeloid leukemia without significant leukocytosis. 共著 2017 [Rinsho ketsueki] The Japanese journal of clinical hematology 58 766-771
Attempt to Harvest a Sufficient Number of Mononuclear Cells in an Appropriate Blood Product Volume By Modification of the Default Apheresis Setting. 共著 2017.10 Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Soc 21 507-511
Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial. 共著 2017.06 Asian spine journal 11 380-389
Persistent symptomatic parvovirus B19 infection with severe thrombocytopenia transmitted by red blood cell transfusion containing low parvovirus B19 DNA levels. 共著 2017.06 Transfusion 57 1414-1418
Management of Pulmonary Mucormycosis Based on a Polymerase Chain Reaction (PCR) Diagnosis in Patients with Hematologic Malignancies: A Report of Four Cases. 共著 2017 Internal medicine (Tokyo, Japan) 56 707-711
Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis. 共著 2017.03 International journal of hematology 105 309-317
Evaluation of the Diagnostic Criteria for the Basic Type of DIC Established by the Japanese Society of Thrombosis and Hemostasis. 共著 2017.10 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 23 838-843
An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis. 共著 2017.09 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 23 579-584
Treatment-free remission after two-year consolidation therapy with nilotinib in patients with chronic myeloid leukemia: STAT2 trial in Japan. 共著 2018.11 Haematologica 103 1835-1842
Congenital Thrombophilia in Patients With Superior Mesenteric Venous Thrombosis or Portal Vein Thrombosis. 共著 2018.10 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 24 1117-1121
Switching to nilotinib is associated with deeper molecular responses in chronic myeloid leukemia chronic phase with major molecular responses to imatinib: STAT1 trial in Japan. 共著 2018.08 International journal of hematology 108 176-183
[Atypical hemolytic uremic syndrome with C3 p.I1157T missense mutation successfully treated with eculizumab]. 共著 2018 [Rinsho ketsueki] The Japanese journal of clinical hematology 59 178-181
Effect of ruxolitinib therapy on the quality-of-life of Japanese patients with myelofibrosis. 共著 2018.03 Current medical research and opinion 34 531-537
The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis. 共著 2018.09 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 24 920-927
Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis. 共著 2018.01 International journal of hematology 107 92-97
Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study. 共著 2018.02 International journal of hematology 107 185-193
An Evaluation of the Activated Partial Thromboplastin Time Waveform. 共著 2018.07 Clinical and applied thrombosis/hemostasis 24 764-770
Infiltrating CCR2(+) monocytes and their progenies, fibrocytes, contribute to colon fibrosis by inhibiting collagen degradation through the production of TIMP-1. 共著 2019.06 Scientific reports 9 8568-
A population of CD20(+)CD27(+)CD43(+)CD38(lo/int) B1 cells in PNH are missing GPI-anchored proteins and harbor PIGA mutations. 単著 2019.07 Blood 134 89-92
Evaluation of Medication Adherence and Pharmacokinetics of Dasatinib for Earlier Molecular Response in Japanese Patients With Newly Diagnosed Chronic Myeloid Leukemia: A Pilot Study. 共著 2019.10 Therapeutic drug monitoring 41 575-581
Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy. 共著 2019.06 Thrombosis research 178 54-58
Comments to: An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia by APTT Waveform, Peak Heights of APTT Waveform Are Useful for Diagnosing Hemophilia or Inhibitor. 共著 2019.01 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 25 1076029618824419-
Routine measurements of factor VIII activity and inhibitor titer in the presence of emicizumab utilizing anti-idiotype monoclonal antibodies: comment. 共著 2019.03 Journal of thrombosis and haemostasis : JTH 17 555-556
Tyrosine kinase inhibitor therapy prescribed for non-urologic diseases can modify PSA titers in urology patients. 共著 2019.02 The Prostate 79 259-264
The valuable diagnosis of DIC and pre-DIC and prediction of a poor outcome by the evaluation of diagnostic criteria for DIC in patients with hematopoietic injury established by the Japanese Society of Thrombosis and Hemostasis. 共著 2016.11 Thrombosis research 147 80-84
Presence of Antiphospholipid Antibodies as a Risk Factor for Thrombotic Events in Patients with Connective Tissue Diseases and Idiopathic Thrombocytopenic Purpura. 共著 2016 Internal medicine (Tokyo, Japan) 55 589-95
Fibrin-related markers for diagnosing acute-, subclinical-, and pre-venous thromboembolism in patients with major orthopedic surgery. 共著 2016.05 International journal of hematology 103 560-6
Plasma ADAMTS13, von Willebrand Factor (VWF), and VWF Propeptide Profiles in Patients With Connective Tissue Diseases and Antiphospholipid Syndrome. 共著 2017.09 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 23 622-630
The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery. 共著 2018.01 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 24 107-114
The efficacy of the administration of recombinant human soluble thrombomodulin in patients with DIC. 共著 2016.02 International journal of hematology 103 173-9
Hypofibrinogenemia and the alpha-Fibrinogen Thr312Ala Polymorphism may be Risk Factors for Early Pregnancy Loss. 共著 2017.01 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/He 23 52-57
High frequency of decreased antithrombin level in pregnant women with thrombosis. 共著 2015.09 International journal of hematology 102 253-8
Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer. 共著 2015.05 Clinical cancer research : an official journal of the American Association for Cancer Research 21 2268-77
A multinational, open-label, phase 2 study of ruxolitinib in Asian patients with myelofibrosis: Japanese subset analysis. 共著 2015.03 International journal of hematology 101 295-304
Efficacy and safety of ruxolitinib in Asian patients with myelofibrosis. 共著 2015.07 Leukemia & lymphoma 56 2067-74
Analysis of patients with atypical hemolytic uremic syndrome treated at the Mie University Hospital: concentration of C3 p.I1157T mutation. 共著 2014.11 International journal of hematology 100 437-42
Successful treatment of non-invasive bladder tumour in a haemophilia A patient with high-responding inhibitors: a case report. 共著 2014.11 Haemophilia 20 e399-401
Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus-associated liver cirrhosis. 共著 2014.12 Hepatology research 44 E376-E385
Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells. 共著 2014 PloS one 9 e84889-
Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy. 共著 2014.03 Thrombosis research 133 440-4
A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis 共著 2010 Exp. Hematol. 38 685-695
Diagnostic value of PCR analysis of bacteria and fungi from blood in empiric-therapy-resistant febrile neutropenia 共著 2010 J Clin Microbiol 48 2030-2036
Ex vivo culture of human cord blood hematopoietic stem/progenitor cells adversely influences their distribution to other bone marrow compartments after intra-bone marrow transplantation 共著 2008 Stem Cells 26 543-549
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: A principal role for flt3 ligand in lymphopoiesis 共著 2012 Br J Haematol 157 674-686
IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells 共著 2012 Int J Oncol 40 53-62
Effect of washing solution on platelet counts following transfusion with twice-washed platelets: a single-patient experience 2010 Transfusion Medicine 20 358-360
Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome. 共著 2010 Int J Hematol 93 47-52
Efficiency of diversion of the first aliquot of blood and prestorage leukoreduction for preventing bacterial contamination in red blood cell concentrates assessed using a rapid polymerase chain reaction-based bacterial detection system. 共著 2011.12 Transfusion medicine (Oxford, England) 21 365-70
Plasma ADAMTS13, von Willebrand factor (VWF) and VWF propeptide profiles in patients with DIC and related diseases. 共著 2012.05 Thrombosis research 129 598-602
IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells. 共著 2012.01 International journal of oncology 40 53-62
A case of three-year-old boy with severe haemophilia A on prophylaxis identified with a chronic subdural haematoma 2 years after the first episode of acute subdural bleeding. 共著 2012.01 Haemophilia : the official journal of the World Federation of Hemophilia 18 e1-2
Ly6C(+) monocytes are extrahepatic precursors of hepatic stellate cells in the injured liver of mice. 共著 2011.09 Experimental hematology 39 934-46
Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome. 2011.01 International journal of hematology 93 47-52
Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy. 共著 2014.03 Thrombosis research 133 440-4
The relationships among hemostatic markers, the withdrawal of fondaparinux due to a reduction in hemoglobin and deep vein thrombosis in Japanese patients undergoing major orthopedic surgery. 共著 2013.10 Clinica chimica acta; international journal of clinical chemistry 425 109-13
Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: potential utility for adoptive immunotherapy. 共著 2013.04 Experimental hematology 41 367-76.e1
Clinical utility of a panfungal polymerase chain reaction assay for invasive fungal diseases in patients with haematologic disorders. 共著 2013.04 European journal of haematology 90 331-9
Presence of antiphospholipid antibody is a risk factor in thrombotic events in patients with antiphospholipid syndrome or relevant diseases. 共著 2013.03 International journal of hematology 97 345-50
Efficiency of diversion of the first aliquot of blood and prestorage leukoreduction for preventing bacterial contamination in red blood cell concentrates assessed using a rapid polymerase chain reaction-based bacterial detection system. 共著 2011.12 Transfusion medicine (Oxford, England) 21 365-70
Plasma ADAMTS13, von Willebrand factor (VWF) and VWF propeptide profiles in patients with DIC and related diseases. 共著 2012.05 Thrombosis research 129 598-602
A case of three-year-old boy with severe haemophilia A on prophylaxis identified with a chronic subdural haematoma 2 years after the first episode of acute subdural bleeding. 共著 2012.01 Haemophilia : the official journal of the World Federation of Hemophilia 18 e1-2
Ly6C(+) monocytes are extrahepatic precursors of hepatic stellate cells in the injured liver of mice. 共著 2011.09 Experimental hematology 39 934-46
Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome. 2011.01 International journal of hematology 93 47-52
A case of three-year-old boy with severe haemophilia A on prophylaxis identified with a chronic subdural haematoma 2 years after the first episode of acute subdural bleeding. 共著 2012.01 Haemophilia : the official journal of the World Federation of Hemophilia 18 e1-2
骨髄線維症(MF)~分子病態の解明から新規薬物治療薬の開発まで~ 脾腫摘出術~歴史と進歩~ 2016.10 医薬ジャーナル
血液内科 共著 2019.05 科学評論社