| 教員紹介トップページへ | 三重大学トップページへ |
| 職名 | 准教授 | |||||||||
| 氏名 | ますだ ゆういち 増田 裕一 |
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| 生年月 | 1981.05 | |||||||||
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| TEL | 059-231-9620 | |||||||||
| FAX | 059-231-9634 | |||||||||
| masuda@bio. (末尾に mie-u.ac.jp を補ってください) | ||||||||||
| 個人のホームページ | http://www.cc.mie-u.ac.jp/~masuda/ | |||||||||
| 学歴 | 京都大学農学部生物機能科学科 学士課程 (2000年04月～2004年03月) 卒業・修了
京都大学大学院農学研究科食品生物科学専攻 修士課程・博士前期課程 (2004年04月～2006年03月) 卒業・修了 京都大学大学院農学研究科食品生物科学専攻 博士課程・博士後期課程 (2006年04月～2009年03月) 卒業・修了 |
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| 学位 | 2009.03 博士（農学） 京都大学
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| 所属学会 | 日本農芸化学会 日本ペプチド学会 有機合成化学協会 日本薬学会 | |||||||||
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| 職歴 | 2009.04～2011.04 京都大学大学院理学研究科化学専攻分子構造化学研究室 日本学術振興会特別研究員（PD）
2011.05～2015.03 東北大学大学院薬学研究科反応制御化学分野 助教 2015.04～2015.12 東北大学大学院薬学研究科反応制御化学分野 分野研究員 (次世代天然物化学技術研究組合特別研究職員) |
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| 学術（芸術）賞 | 第45回ペプチド討論会若手口頭発表優秀賞,2008.10,日本ペプチド学会
2008年度BBB論文賞,2009.03,日本農芸化学会 日本農芸化学会2015年度大会トピックス賞,2015.04,日本農芸化学会 平成30年度日本ペプチド学会 奨励賞,2018.12,日本ペプチド学会 2020年度農芸化学奨励賞,2020.03,日本農芸化学会 |
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| 専門分野 | 生物有機化学，ペプチド化学，固体NMR | |||||||||
| 現在の研究課題 | ・アポリポタンパク質Bの産生を抑制する環状ペプチドの作用機序解明
・カイコ麻痺を惹起する環状ペプチドの作用機序解明 ・ペプチドグリカン前駆体を認識する抗菌環状ペプチドの全合成 ・希少アミノ酸を含む抗菌環状ペプチドの作用機序解明 ・膜透過性が高い環状ペプチドのスクリーニング法の開発 ・アテモヤの種子に含まれる生物活性物質の単離・構造決定と作用機序解明 |
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| 担当科目 | 化学概論 生命機能化学演習Ⅰ 生命機能化学演習Ⅱ 生命機能化学実験実習２ 生命機能化学特別研究Ⅰ 生命機能化学特別研究Ⅱ 生命機能化学特論１ 生理活性化学演習 生理活性化学特論 創薬化学 卒業研究 | |||||||||
| 主な業績等 | [原著論文]
Yamada, K.*, Masuda, Y.*: A sulfur-33 nuclear quadrupole resonance study of 33S2-labeled L-cystine. Magn. Reason. Chem. 2023, 61, 296–300. Honda, M., Inagaki, M., Masuda, Y.*: Total synthesis of the cyclic pentapeptides PF1171B, D, E, and avellanins A, B, C with inhibitory activity against apolipoprotein B production. Tetrahedron Lett., 2021, 81, 153340. Yoshida, Y., Inagaki, M., Masuda, Y.*: Solid-phase synthesis and bioactivity evaluation of cherimolacyclopeptide E. J. Pept. Sci., 2021, 27, e3308. Tanaka, F., Shibata, K., Monobe, Y., Akagi, K., Masuda, Y.*: Design and synthesis of beta-strand-fixed peptides inhibiting aggregation of amyloid beta-protein. Bioorg. Med. Chem. 2020, 28, 115676. Onda, Y., Fukushi, K., Ohsawa, K., Yoshida, M., Masuda, Y., Doi, T.*: Synthesis of a biphenylalanine analogue of apratoxin a displaying substantially enhanced cytotoxicity. Heterocycles, 2020, 101, 679－691. Professor Kaoru Fuji Special Issue Ohsawa, K, Zhao, H., Tokunaga, T., Thomas, C., Ganesan, A., Masuda, Y., Doi T.*: Stereoselective synthesis of protected L-allo-Enduracididine and L-Enduracididine via asymmetric nitroaldol reaction. Synthesis 2020, 52, 942–948. Kuriya, K., Nishio, M.*, Ono, N., Masuda, Y., Katsuzaki, H., Kondo, S., Sono, J., Nakamura, M., Umekawa, H.: Isolation and characterization of antihyperglycemic compounds from Vigna angularis extracts. J. Food. Sci. 2019, 84, 3172–3178. Ohsawa, K., Sugai, M., Zhang, L., Masuda, Y., Yoshida, M., Doi, T.*: Total synthesis and structural revision of cyclotetrapeptide asperterrestide A. J. Org. Chem. 2019, 84, 6765–6779. D’Amato, A., Della Sala, G., Izzo, I., Costabile, C., Masuda, Y.*, De Riccardis, F.*: Cyclic octamer peptoids: simplified isosters of bioactive fungal cyclodepsipeptides. Molecules 2018, 23, 1779. Masuda, Y.*, Tanaka, R., Ganesan, A., Doi, T.*: Systematic analysis of relationship among 3D structure, bioactivity, and membrane permeability of PF1171F, a cyclic hexapeptide with paralyzing effects on silkworms. J. Org. Chem. 2017, 82, 11447–11463. Onda, Y., Masuda, Y., Yoshida, M., Doi, T.*: Conformation-based design and synthesis of apratoxin A mimetics modified at the α,β-unsaturated thiazoline moiety. J. Med. Chem., 2017, 60, 6751–6765. Masuda, Y., Maruyama, C., Kawabata, K., Hamano, Y., Doi, T.*: Synthesis of (2S,3R,4R)-3,4-dihydroxyarginine and its inhibitory activity against nitric oxide synthase. Tetrahedron 2016, 72, 5602–5611. Masuda, Y., Aoyama, K., Yoshida, M., Kobayashi, K., Ohshiro, T., Tomoda, H., Doi T.*: Design, synthesis, and biological evaluation of beauveriolide analogues bearing photoreactive amino acids. Chem. Pharm. Bull., 2016, 64, 754–765. Special Collection of Papers Celebrating Professor Satoshi Ōmura's 2015 Nobel Prize in Physiology or Medicine. Yoshida, M., Onda, Y., Masuda, Y., Doi, T.*: Potent oxazoline analogue of apratoxin C: synthesis, biological evaluation, and conformational analysis. Biopolymers (Peptide Science), 2016, 106, 404–414. Special Issue: Emerging Peptide Science from Japan. Kawahara, T., Kagaya, N., Masuda, Y., Doi, T., Izumikawa, M., Ohta, K., Hirao, A., Shin-Ya, K.*: Foxo3a inhibitors of microbial origin, JBIR-141 and JBIR-142. Org. Lett. 2015, 17, 5476–5479. Masuda, Y., Tanaka, R., Ganesan, A.,* Doi, T.*: Structure revision of similanamide to PF1171C by total synthesis. J. Nat. Prod. 2015, 78, 2286–2291. Masuda, Y., Suzuki, J., Onda, Y., Fujino, Y., Yoshida, M., Doi, T.*: Total synthesis and conformational analysis of apratoxin C. J. Org. Chem. 2014, 79, 8000–8009. Masuda, Y., Tanaka, R., Kai, K., Ganesan, A.,* Doi, T.*: Total synthesis and biological evaluation of PF1171A, C, F, and G, cyclic hexapeptides with insecticidal activity. J. Org. Chem. 2014, 79, 7844－7853. Shen, M., Liu, Q., Trébosc, J., Lafon, O., Masuda, Y., Takegoshi, K., Amoureux, J. P.,* Hu, B.,* Chen, Q.: Exploring various modulation-sideband recoupling conditions of SHA+ sequence at fast MAS. Solid State Nucl. Magn. Reson. 2013, 55-56, 42–47. Sato, M., Murakami, K., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K., Masuda, Y., Takegoshi, K., Irie, K.*: Site-specific inhibitory mechanism for amyloid-beta 42 aggregation by catechol-type flavonoids targeting the Lys residues. J. Biol. Chem. 2013, 288, 23212–23224. Doi, T., Masuda, Y.*, Irie, K., Akagi, K., Monobe, Y., Imazawa, T., Takegoshi, K.: Solid-state NMR analysis of the beta-strand orientation of the protofibrils of amyloid beta-protein. Biochem. Biophys. Res. Commun. 2012, 428, 458-462. Hu, B.*, Trébosc, J., Lafon, O., Chen, Q., Masuda, Y., Takegoshi, K., Amoureux, J. P.*: Very-long-distance correlations in proteins revealed by solid-state NMR spectroscopy. ChemPhysChem 2012, 13, 3585–3588. Tsuji, F., Ishihara, A., Nakagawa, A., Okada, M., Kitamura, S., Kanamaru, K., Masuda, Y., Murakami, K., Irie, K., Sakagami, Y.*: Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor. Biosci. Biotechnol. Biochem. 2012, 76, 1492–1496. Tsuji, F., Ishihara, A., Kurata, K., Nakagawa, A., Okada, M., Kitamura, S., Kanamaru, K., Masuda, Y., Murakami, K., Irie, K., Sakagami, Y.*: Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system. FEBS Lett. 2012, 586, 174–179. Masuda, Y.*, Fukuchi, M., Yatagawa, T., Tada, M., Takeda, K., Irie, K., Akagi, K., Monobe, Y., Imazawa, T., Takegoshi, K.: Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid beta -protein fibrils. Bioorg. Med. Chem. 2011, 19, 5967–5974. Nakagawa, Y.*, Doi, T., Masuda, Y., Takegoshi, K., Igarashi, Y., Ito, Y.*: Mapping of the primary mannose-binding site of pradimicin A. J. Am. Chem. Soc. 2011, 133, 17485–17493. Nakagawa, Y.*, Masuda, Y., Yamada, K., Doi, T., Takegoshi, K., Igarashi, Y., Ito, Y.*: Solid-state NMR spectroscopic analysis of the Ca2+-dependent mannose binding of pradimicin A. Angew. Chem. Int. Ed. 2011, 50, 6084-6088. Weingarth, M., Masuda, Y., Takegoshi, K., Bodenhausen, G., Tekely, P.*: Sensitive 13C-13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields. J. Biomol. NMR 2011, 50, 129–136. Murakami, K., Horikoshi-Sakuraba, Y., Murata, N., Noda, Y., Masuda, Y., Kinoshita, N., Hatsuta, H., Murayama, S., Shirasawa, T., Shimizu, T.,* Irie, K.*: Monoclonal antibody against the turn of the 42-residue amyloid beta -protein at positions 22 and 23. ACS Chem. Neurosci. 2010, 1, 747–756. Kondo, T., Kajita, R., Miyazaki, A., Hokoyama, M., Nakamura-Miura, T., Mizuno, S., Masuda, Y., Irie, K., Tanaka, Y., Takada, S., Kakimoto, T., Sakagami, Y.*: Stomatal density is controlled by a mesophyll-derived signaling molecule. Plant Cell Physiol. 2010, 51, 1–8. Masuda, Y., Uemura, S., Ohashi, R., Nakanishi, A., Takegoshi, K., Shimizu, T., Shirasawa, T., Irie, K.*: Identification of physiological and toxic conformations in Abeta42 aggregates. ChemBioChem 2009, 10, 287–295. Masuda, Y., Nakanishi, A., Ohashi, R., Takegoshi, K., Shimizu, T., Shirasawa, T., Irie, K.*: Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: Implications for the supramolecular arrangement of the toxic conformer of Abeta42. Biosci. Biotechnol. Biochem. 2008, 72, 2170–2175. Masuda, Y., Uemura, S., Nakanishi, A., Ohashi, R., Takegoshi, K., Shimizu, T., Shirasawa, T., Irie, K.*: Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals. Bioorg. Med. Chem. Lett. 2008, 18, 3206–3210. Murakami, K., Uno, M., Masuda, Y., Shimizu, T., Shirasawa, T., Irie, K.*: Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. Biochem. Biophys. Res. Commun. 2008, 366, 745–751. Murakami, K., Hara, H., Masuda, Y., Ohigashi, H., Irie, K.*: Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: Implications for the stronger neurotoxicity of Abeta42 than Abeta40. ChemBioChem 2007, 8, 2308–2314. Masuda, Y., Irie, K.,* Murakami, K., Ohigashi, H., Ohashi, R., Takegoshi, K., Shimizu, T., Shirasawa, T.: Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. Bioorg. Med. Chem. 2005, 13, 6803–6809. Morimoto, A., Irie, K.,* Murakami, K., Masuda, Y., Ohigashi, H., Nagao, M., Fukuda, H., Shimizu, T., Shirasawa, T.: Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement. J. Biol. Chem. 2004, 279, 52781–52788. [総説・解説] Masuda, Y.*: Bioactive 3D structures of naturally occurring peptides and their application in drug design. Biosci. Biotechnol. Biochem. 2021, 85, 24–32. 増田裕一*，土井隆行*: 天然物に学ぶ環状ペプチドの三次元構造制御．CSJ Current Review 36：生体分子反応を制御する～化学的手法による機構と反応場の解明.（化学同人） 2020, 13, 120–127. Doi, T.,* Masuda, Y., Yoshida, M.: Cyclodepsipeptide Natural Products Apratoxins A and C and Their Analogs. J. Synth. Org. Chem. Jpn. 2018, 76 (11), 1170–1175. 増田裕一: 中分子で免疫チェックポイントを制御する．ファルマシア 2018, 54 (6), 574. 増田裕一*，土井隆行: 生物活性環状ペプチドPF1171類とapratoxin Cの全合成と三次元構造解析．化学工業 2016, 67, 18–25. 村上一馬，増田裕一，入江一浩*: 固体NMRおよびESRによるアミロイドβの立体構造解析と毒性ターン構造特異抗体の開発. 遺伝子医学MOOK 2012, 21, 211–216. Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T.,* Irie, K.*: The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: The emerging role in the pathogenesis of Alzheimer’s disease. Geriatr. Gerontol. Int. 2010, 10, S169–S179. 増田 裕一, 入江 一浩*: ポリフェノールによるアルツハイマー病予防の可能性. FFIジャーナル 2010, 215, 53–59. 入江 一浩,* 増田 裕一:βアミロイドの毒性コンホメーション. 化学と生物 2008, 46, 431–434. Irie, K.,* Murakami, K., Masuda, Y., Morimoto, A., Ohigashi, H., Hara, H., Ohashi, R., Takegoshi, K., Fukuda, H., Nagao, M., Shimizu, T., Shirasawa, T.: The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer’s disease. Mini-Rev. Med. Chem. 2007, 7, 1001–1008. Irie, K.,* Murakami, K., Masuda, Y., Morimoto, A., Ohigashi, H., Ohashi, R., Takegoshi, K., Nagao, M., Shimizu, T., Shirasawa, T.: Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: Implications for the pathogenesis of Alzheimer’s disease. J. Biosci. Bioeng. 2005, 99, 437–447. [招待講演] Masuda, Y.: Elucidation of important 3D structures for bioactivity of naturally occurring peptides. 23rd Korean Peptide and Protein Society Symposium, Invited lecture (Daemyung Resort, Sol Beach Yangyang, South Korea) , July 1~2, 2019． 増田裕一: 生物活性環状ペプチドの合成と三次元構造解析. 日本薬学会東北支部 第13回化学系若手研究者セミナー (仙台) 2014年9月. Masuda, Y.: Identification of Toxic Conformation in the Aggregates of 42-residue Amyloid beta-Protein. Seminar in Unité de Catalyse et de Chimie du Solide (UCCS) – UMR CNRS 8181, University of Lille, (Lille, France) Novemver 2009. Masuda, Y.: Identification of Toxic Conformation in the Aggregates of 42-residue Amyloid beta-Protein. Seminar in Département de Chimie, Ecole Normale Supérieure (Paris, France) Novemver 2009. [特許] 増田裕一，杉山恵里: アミロイドβの凝集体の測定方法．特願2020-18764（出願日: 2020年2月6日）． 土井隆行，吉田将人，増田裕一，恩田勇一: 新規環状デプシペプチド化合物．PCT/JP2017/005777 (2017). Irie, K., Murakami, K., Masuda, Y., Shimizu, T., Shirasawa, T., Seito, T.: Antibody recognizing turn structure in amyloid beta. 特許登録US 8,710,193; CN ZL201080046483.9 (2014). |
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