| 教員紹介トップページへ | 三重大学トップページへ |
| 職名 | 准教授 | |||||||||
| 氏名 | かさはら こうすけ 笠原 広介 |
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| 生年月 | 1978.07 | |||||||||
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| kkasahara@doc.medic. (末尾に mie-u.ac.jp を補ってください) | ||||||||||
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| 学歴 | 2001.3 千葉大学薬学部 卒業
2003.3 千葉大学大学院医学薬学府総合修士課程 修了 2006.3 千葉大学大学院医学薬学府博士課程 修了 |
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| 学位 | 博士（医薬学） | |||||||||
| 所属学会 | 日本癌学会 、日本分子生物学会 | |||||||||
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| 職歴 | 2006.4〜2007.3 日本学術振興会特別研究員PD
2007.4〜2017.9 愛知県がんセンター研究所 研究員 2011.4〜2017.9 名古屋市立大学薬学部腫瘍生物学 客員准教授 2017.10～ 三重大学医学系研究科分子生理学 准教授 |
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| 学術（芸術）賞 | 2011 NAGOYOグローバルCOEリサーチアワード
2018 日本癌学会奨励賞 |
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| 専門分野 | 細胞生物学、分子生物学、病態医化学 | |||||||||
| 現在の研究課題 | 一次シリアによる細胞増殖制御機構の解明 | |||||||||
| 担当科目 | 生理学2、人体機能学 | |||||||||
| 主な業績等 | Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain. 2004.06 The Journal of cell biology 165 641-52
Involvement of Golgi-associated Lyn tyrosine kinase in the translocation of annexin II to the endoplasmic reticulum under oxidative stress. 2006.04 Experimental cell research 312 1205-17 Src signaling regulates completion of abscission in cytokinesis through ERK/MAPK activation at the midbody. 2007.02 The Journal of biological chemistry 282 5327-39 Role of Src-family kinases in formation and trafficking of macropinosomes. 2007.04 Journal of cellular physiology 211 220-32 Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes. 2007.07 Experimental cell research 313 2651-66 Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells. 2007.10 Archives of biochemistry and biophysics 466 116-24 Nuclear localization of magphinins, alternative splicing products of the human trophinin gene. 2008.02 Journal of cellular biochemistry 103 765-77 v-Src and c-Src, nonpalmitoylated Src-family kinases, induce perinuclear accumulation of lysosomes through Rab7 in a kinase activity-independent manner. 2008.04 Cancer letters 262 19-27 Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface. 2008.06 Experimental cell research 314 2040-54 Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity. 2008.11 Experimental cell research 314 3392-404 Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation. 2008.12 Biochemical and biophysical research communications 377 1227-31 [Regulation of mitosis by mitotic kinases]. 2009.03 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54 441-6 Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. 2009.04 Journal of cell science 122 965-75 Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. 2009.04 Experimental cell research 315 1117-41 Requirement of the SH4 and tyrosine-kinase domains but not the kinase activity of Lyn for its biosynthetic targeting to caveolin-positive Golgi membranes. 2009.10 Biochimica et biophysica acta 1790 1345-52 Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition. 2009.12 The Journal of biological chemistry 284 34223-30 Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. 2010.03 The Journal of biological chemistry 285 7657-69 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. 2010.08 The EMBO journal 29 2802-12 Nuclear Chk1 prevents premature mitotic entry. 2011.07 Journal of cell science 124 2113-9 P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation. 2012.04 Molecular biology of the cell 23 1582-92 PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3ﾎｳ and is required for metaphase-anaphase transition. 2013 Nature communications 4 1882- Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. 2014.10 Nature communications 5 5081- Current topics of functional links between primary cilia and cell cycle. 2015 Cilia 4 12- Novel insights into Chk1 regulation by phosphorylation. 2015 Cell structure and function 40 43-50 Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis. 2015 PloS one 10 e0133399- Phospho-Specific Antibody Probes of Intermediate Filament Proteins. 2016 Methods in enzymology 568 85-111 Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. 2016.02 The Journal of cell biology 212 409-23 Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues. 2016.09 Biochemical and biophysical research communications 478 1323-9 Sphingosine 1-phosphate signaling through its receptor S1P(5) promotes chromosome segregation and mitotic progression. 2017.03 Science signaling 10 EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. 2018.02 Nature communications 9 758- Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase. 2018.04 Biochemical and biophysical research communications 498 544-550 Tetraploidy in cancer and its possible link to aging. 2018.09 Cancer science 109 2632-2640 Intermediate filaments and IF-associated proteins: from cell architecture to cell proliferation. 2019 Proceedings of the Japan Academy. Series B, Physical and biological sciences 95 479-493 Primary Cilia as Signaling Hubs in Health and Disease. 2019.01 Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 1801138- A novel CDK-independent function of p27(Kip1) in preciliary vesicle trafficking during ciliogenesis. 2020.06 Biochemical and biophysical research communications 527 716-722 Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer. 2020.08 International journal of molecular sciences 21 |
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