職名 特任教員(研究担当)
氏名 たに かずとし
谷 一寿
生年月  
所属 部局 医学系研究科
学科・専攻  
講座  
教育研究分野  
TEL  
FAX  
E-mail ktani@doc.medic. (末尾に mie-u.ac.jp を補ってください)
個人のホームページ https://www.cryoem-tokai.jp/
学歴 東京工業大学 学士課程 (1990年04月~1994年03月) 卒業・修了
東京工業大学大学院 修士課程・博士前期課程 (1994年04月~1996年03月) 卒業・修了
東京大学大学院 博士課程・博士後期課程 (1996年04月~1999年08月) 満了
学位 2007.09 博士(理学) 名古屋大学
所属学会 日本生物物理学会 日本顕微鏡学会 日本分子生物学学会 日本蛋白質科学会 日本生物工学会
社会活動  
職歴 1999.09~2002.02 理化学研究所ゲノム科学総合研究センター テクニカルスタッフ
2002.03~2002.03 京都大学大学院理学研究科 教務補佐員
2002.04~2008.12 日本電子(株) 研究員(京都大学出向)
2009.01~2012.03 京都大学大学院理学研究科 特定助教
2012.04~2015.03 名古屋大学・細胞生理学研究センター 特任准教授
2015.04~2018.03 名古屋大学・細胞生理学研究センター 特任教授
2019.04~ 三重大学・医学系研究科 特任教員(特任教授)
学術(芸術)賞 第7回 風戸賞
第30回 日本顕微鏡学会論文賞(応用研究生物学部門)
専門分野 構造生物学、生物物理学
現在の研究課題 クライオ電子顕微鏡を用いた膜蛋白質の立体構造解析と機能相関
担当科目  
主な業績等 A previously unrecognized membrane protein in the Rhodobacter sphaeroides LH1-RC photocomplex. 共著 2021.11 Nature communications 12 6300-
Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum. 共著 2021.07 Biochemistry
Leucine Dehydrogenase: Structure and Thermostability. 共著 2021 Sub-cellular biochemistry 96 355-372
Structural insights into the targeting specificity of ubiquitin ligase for S. cerevisiae isocitrate lyase but not C. albicans isocitrate lyase. 共著 2021 Journal of Structural Biology
Leucine Dehydrogenase: Structure and Thermostability. 2021 Sub-cellular biochemistry 96 355-372
Cryo-EM structure of a Ca(2+)-bound photosynthetic LH1-RC complex containing multiple αβ-polypeptides. 2020.10 Nature communications 11 4955-
Characterization of Critical Residues in the Extracellular and Transmembrane Domains of the Endothelin Type B Receptor for Propagation of the Endothelin-1 Signal. 2020.05 Biochemistry 59 1718-1727
Development of a deep learning-based method to identify "good" regions of a cryo-electron microscopy grid. 2020.04 Biophysical reviews 12 349-354
Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. 2020.02 Science advances 6 eaax3157-
Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy. 2019.01 Journal of structural biology 205 11-21
X-ray structures of endothelin ET(B) receptor bound to clinical antagonist bosentan and its analog. 2017.09 Nature structural & molecular biology 24 758-764
The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors. 2017.07 Scientific reports 7 6632-
Crystal structures of claudins: insights into their intermolecular interactions. 2017.06 Annals of the New York Academy of Sciences 1397 25-34
Atomic structure of the innexin-6 gap junction channel determined by cryo-EM. 2016.12 Nature communications 7 13681-
Activation mechanism of endothelin ET(B) receptor by endothelin-1. 2016.09 Nature 537 363-368
Thermostabilization of the Human Endothelin Type B Receptor. 2016.06 Journal of molecular biology 428 2265-2274
Hexadecameric structure of an invertebrate gap junction channel. 2016.03 Journal of molecular biology 428 1227-1236
Two-dimensional crystallization of monomeric bovine cytochrome c oxidase with bound cytochrome c in reconstituted lipid membranes. 2016.06 Microscopy (Oxford, England) 65 263-7
Claudin-21 Has a Paracellular Channel Role at Tight Junctions. 2016.01 Molecular and cellular biology 36 954-64
Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide. 2016.04 Microscopy (Oxford, England) 65 177-84
Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals. 2015.03 eLife 4 e06119-
Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. 2015.02 Science (New York, N.Y.) 347 775-8
Model for the architecture of claudin-based paracellular ion channels through tight junctions. 2015.01 Journal of molecular biology 427 291-7
Systematic comparison of molecular conformations of H+,K+-ATPase reveals an important contribution of the A-M2 linker for the luminal gating. 2014.10 The Journal of biological chemistry 289 30590-601
Crystal structure of a claudin provides insight into the architecture of tight junctions. 2014.04 Science (New York, N.Y.) 344 304-7
Three-dimensional structure of bovine heart NADH: ubiquinone oxidoreductase (complex I) by electron microscopy of a single negatively stained two-dimensional crystal. 2014.04 Microscopy (Oxford, England) 63 167-74
Two-dimensional crystallization of intact F-ATP synthase isolated from bovine heart mitochondria. 2013.12 Acta crystallographica. Section F, Structural biology and crystallization communications 69 1368-70
Water channel structures analysed by electron crystallography. 2014.05 Biochimica et biophysica acta 1840 1605-13
Carbon sandwich preparation preserves quality of two-dimensional crystals for cryo-electron microscopy. 2013.12 Microscopy (Oxford, England) 62 597-606
Two alternative conformations of a voltage-gated sodium channel. 2013.11 Journal of molecular biology 425 4074-88
Visualization of two distinct states of disassembly in the bacterial V-ATPase from Thermus thermophilus. 2013.08 Microscopy (Oxford, England) 62 467-74
The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat. 2013 Nature communications 4 1766-
Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site. 2012.11 Proceedings of the National Academy of Sciences of the United States of America 109 18401-6
Water permeability and characterization of aquaporin-11. 2011.05 Journal of structural biology 174 315-20
Conformational rearrangement of gastric H(+),K(+)-ATPase induced by an acid suppressant. 2011.01 Nature communications 2 155-
Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. 2011.01 Journal of molecular biology 405 724-35
Influence of the cytoplasmic domains of aquaporin-4 on water conduction and array formation. 2010.10 Journal of molecular biology 402 669-81
Structural and functional characterization of H+, K+-ATPase with bound fluorinated phosphate analogs. 2010.04 Journal of structural biology 170 60-8
Mechanism of aquaporin-4's fast and highly selective water conduction and proton exclusion. 2009.06 Journal of molecular biology 389 694-706
Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle. 2009.06 The EMBO journal 28 1637-43
Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore density. 2008.05 Cell communication & adhesion 15 85-93
Structural analysis of 2D crystals of gastric H+,K+-ATPase in different states of the transport cycle. 2008.05 Journal of structural biology 162 219-28
Dodecamer rotor ring defines H+/ATP ratio for ATP synthesis of prokaryotic V-ATPase from Thermus thermophilus. 2007.12 Proceedings of the National Academy of Sciences of the United States of America 104 20256-61
Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule. 2007.06 Proceedings of the National Academy of Sciences of the United States of America 104 10034-9
Two-dimensional crystallization and analysis of projection images of intact Thermus thermophilus V-ATPase. 2006.02 Journal of structural biology 153 200-6
Implications of the aquaporin-4 structure on array formation and cell adhesion. 2006.01 Journal of molecular biology 355 628-39
Improved specimen preparation for cryo-electron microscopy using a symmetric carbon sandwich technique. 2004.06 Journal of structural biology 146 325-33
Inositol 1,4,5-trisphosphate receptor contains multiple cavities and L-shaped ligand-binding domains. 2004.02 Journal of molecular biology 336 155-64
Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16). 2004.03 The Journal of biological chemistry 279 13174-82
Solution structure of a BolA-like protein from Mus musculus. 2004.02 Protein science : a publication of the Protein Society 13 545-8