教員紹介トップページへ 三重大学トップページへ
職名 特任講師（教育担当）
氏名 ぞう　れいしん
臧　黎清
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所属 部局 地域イノベーション学研究科
学科・専攻 バイオイノベーションユニット
講座  
教育研究分野  
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E-mail liqing.innov@mie-u.ac.jp
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学歴  
学位 2012.07 博士 三重大学大学院医学系研究科
所属学会 日本薬理学会
日本生化学会
日本未病学会
日本分子生物学会
日本女性科学者の会
社会活動  
職歴 2000.07～2001.09 中国山東省青島市膠南経済技術開発区病院 医師
2006.07～2007.09 三重大学大学院医学系研究科 助教
2007.09～2015.12 三重大学大学院医学系研究科 技官
2016.01～ 三重大学大学院地域イノベーション学研究科 助教
2017.02～2018.03 アメリカバンダビルド大学 訪問学者
2021.04～ 三重大学大学院地域イノベーション学研究科 　特任講師（教育・研究担当）
学術（芸術）賞 2015年10月　優秀演題賞 第22回日本未病システム学会学術総会
2018年10月　最優秀論文賞 第25回日本未病システム学会学術総会
2021年11月　最優秀論文賞 第28回日本未病システム学会学術総会
2022年11月　優秀演題賞　第29回日本未病システム学会学術総会
専門分野 ライフサイエンス
現在の研究課題 ２型糖尿病性腎症モデルゼブラフィッシュの構築および治療標的遺伝子の探索
担当科目 バイオイノベーション学特論Ⅲ
主な業績等 *, Corresponding author; †, Co-first author
1. 臧黎清*.　ゼブラフィッシュを用いた深紫外線（UVC）の生体安全性確認及びDNA損傷修復機構の解明　アグリバイオ. 2023:7(1);57-59
2. 臧黎清*、島田康人、西村訓弘.　グロビン蛋白分解物による内臓脂肪型肥満改善メカニズムの解明　Bio Clinica. 2022:38(1);84-86
3. 臧黎清*、島田康人、西村訓弘.　ゼブラフィッシュ創薬：グロビンペプチドは内臓脂肪のUCP1発現増加を介して肥満を改善する Bio Clinica. 2022:37(12); p63-65.
4. Jacky Bhagat, Liqing Zang, Norihiro Nishimura, Yasuhito Shimada*. Application of omics approaches for assessing microplastic and nanoplastic toxicity in fish and seafood species. TRAC-Trend Anal Chem. 2022;154:116674.
5. 臧黎清*、島田康人．「治未病」に効く緑茶抽出物 - 肥満ゼブラフィッシュで解明　アグリバイオ. 2022:6(7); p81-83.
6. Jacky Bhagat, Liqing Zang, Satoshi Kaneco, Norihiro Nishimura, Yasuhito Shimada*. Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. Sci Total Environ. 2022;835:155436.
7. Liqing Zang, Norihiro Nishimura, Vincenzo Torraca, Yasuhito Shimada. Zebrafish Models for Human Disease Studies. Frontiers Media SA. 2022. doi: 10.3389/978-2-88974-832-7 [e-Book]
8. Izumi Matsuoka, Kanae Hata, Hirotaka Katsuzaki, Hiroko Nakayama, Liqing Zang, Mizuho Ota, Youngil Kim, Djong-Chi Chu, Lekh Raj Juneja, Norihiro Nishimura, Yasuhito Shimada*. Zebrafish obesogenic test identifies anti-adipogenic fraction in Moringa oreifera leaf extracts. Food Sci Nurt. 2022;00:1-9.
9. Liqing Zang*, Vincenzo Torraca, Yasuhito Shimada, Norihiro Nishimura. Editorial: Zebrafish Models for Human Disease Studies: Front Cell Dev Biol. 2022;10:861941..
10. Liqing Zang*, Yasuhito Shimada, Hideto Miyake, Norihiro Nishimura. Transcriptome Analysis of Molecular Response to UVC Irradiation in Zebrafish Embryos. Ecotoxicol Environ Safe. 2022;231:113211.
11. 臧黎清*、島田康人、西村訓弘. 「グロビン蛋白分解物はUCP1発現増加を誘導し内臓脂肪型肥満を改善する」 Precision Medicine. 2021: 4(13); 1275-1277.
12. 臧黎清*、島田康人、西村訓弘. 「ゼブラフィッシュを用いた天然物創薬：グロビン蛋白分解物の抗肥満作用の発見」 Medical Science Digest. 2021: 47(11); 596-598.
13. Liqing Zang*, Yasuhito Shimada, Hiroko Nakayama, Izumi Matsuoka, Youngil Kim, Djong-Chi Chu, Lekh Raj Juneja, Rika Tsuruta, Yuka Sasakawa, Junya Kuroyanagi, Norihiro Nishimura. Globin digest improves visceral adiposity through UCP1 upregulation in diet-induced obese zebrafish and mice. Front Nurt. 2021;8:650975.
14. 松浦信男、松下彬子、臧黎清、西村訓弘、島田康人*. 「乳酸発酵ハナビラタケによる脂肪肝改善作用」 日本未病システム学会雑誌2022, 27巻, 3号; 77-80.
15. Jacky Bhagat, Liqing Zang, Hiroko Nakayama, Norihiro Nishimura, Yasuhito Shimada*. Effects of nanoplastic on toxicity of azole fungicides (ketoconazole and fluconazole) in zebrafish embryos. Sci Total Environ. 2021;800:149463.
16. Yasuhito Shimada*, Masahiro Terasawa, Fumiyoshi Okazaki, Hiroko Nakayama, Liqing Zang, Kaoru Nishiura, Koichi Matsuda, Norihiro Nishimura. Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial. Sci Rep. 2021;11:13384.
17. Liqing Zang*, Yasuhito Shimada, Hiroko Nakayama, Hirotaka Katsuzaki, Youngil Kim, Djong-Chi Chu, Lekh Raj Juneja, Junya Kuroyanagi, Norihiro Nishimura. Preventive Effects of Green Tea Extract against Obesity Development in Zebrafish. Molecules. 2021, 26, 2627.
18. Liqing Zang†, Kazuhiro Kagotani†, Hiroko Nakayama, Jacky Bhagat, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Hirotaka Katsuzaki, Norihiro Nishimura, Yasuhito Shimada*. 10-Gingerol Suppresses Osteoclastogenesis in RAW264.7 Cells and Zebrafish Osteoporotic Scales. Front. Cell Dev. Biol. 2021;9:588093.
19. Bingyuan Yang, Lisette A. Maddison1, Karolina E. Zaborska, Chunhua Dai, Linlin Yin, Zihan Tang, Liqing Zang, David A. Jacobson, Alvin C. Powers, Wenbiao Chen*. RIPK3-mediated inflammation is a conserved β cell response to ER stress. Sci. Adv. 2020;6:eabd7272.
20. Hiroko Nakayama†, Kanae Hata, Izumi Matsuoka, Liqing Zang, Youngil Kim, Djongchi Chu, Lekh Raj Juneja, Norihiro Nishimura, Yasuhito Shimada*†. Anti-Obesity Natural Products Tested in Juvenile Zebrafish Obesogenic Tests and Mouse 3T3-L1 Adipogenesis Assays. Molecules. 2020, 25, 5840
21. 臧黎清*、島田康人、中山寛子、西村訓弘．「2型糖尿病モデル動物におけるCENPX遺伝子発現抑制による血糖低下作用」日本未病学会雑誌. 2020, 26(3):65-68.
22. 松岡いづみ、中山寛子、幡佳苗、臧黎清、金英一、朱政治、ジュネジャレカ、西村訓弘、島田康人*. 「ゼブラフィッシュ稚魚を用いた抗肥満スクリーニング技術の開発」日本未病学会雑誌. 2020, 26(3):74-77
23. 臧黎清*、中山寛子．「ゼブラフィッシュを用いた緑茶抽出物の抗肥満作用メカニズムの解明」アグリバイオ. 2020, 4:58-60
24. Daizo Morikane†, Liqing Zang*†, Norihiro Nishimura. Evaluation of the percutaneous absorption of drug molecules in zebrafish. Molecules. 2020;25:3974.
25. Nobuo Matsuura†, Liqing Zang†, Norihiro Nishimura, Yasuhito Shimada*. Lacto-fermented Cauliflower fungus (Sparassis crispa) ameliorates hepatic steatosis by activating beta-oxidation in a diet-induced obese zebrafish. J Med Food. 2020;23:803-810.
26. Jacky Bhagat, Liqing Zang, Norihiro Nishimura, Yasuhito Shimada*. Zebrafish: An emerging model to study microplastic and nanoplastic toxicity. Sci Total Environ. 2020;728:138707.
27. Kazuhiro Kagotani†, Hiroko Nakayama, Liqing Zang, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Norihiro Nishimura and Yasuhito Shimada*†. Lecithin-based dermal drug delivery for anti-pigmentation maize ceramide. Molecules. 2020;25;1595.
28. Yuka Yamada, Sasicha Chensom, Hisataka Yonemoto, Hiroko Nakayama, Liqing Zang, Norihiro Nishimura, Takashi Mishima, and Yasuhito Shimada*. Water extract of Yamato-Tachibana (Citrus tachibana) induces food intake in adult and larval zebrafish. J Med Food. 2020;23:65-71.
29. Liqing Zang*, Yasuhito Shimada, Hiroko Nakayama, Youngil Kim, Djong-Chi Chu, Lekh Raj Juneja, Junya Kuroyanagi, Norihiro Nishimura. RNA-seq based transcriptome analysis of the anti-obesity effect of green tea extract using zebrafish obesity models. Molecules. 2019;24:3256.
30. Yasuyuki Monma, Yasuhito Shimada, Hiroko Nakayama, Liqing Zang, Norihiro Nishimura, Toshio Tanaka*. Aging-associated Microstructural Deterioration of Vertebra in Zebrafish. Bone Rep. 2019;11:100215.
31. Liqing Zang*, Yasuhito Shimada, Hiroko Nakayama, Wenbiao Chen, Ayaka Okamoto, Hiroyuki Koide, Naoto Oku, Takehisa Dewa, Masayuki Shiota and Norihiro Nishimura. Therapeutic silencing of centromere protein X ameliorates hyperglycemia in zebrafish and mouse models of type 2 diabetes mellitus. Front Genet. 2019;10:693.
32. Fumiyoshi Okazaki†, Liqing Zang, Hiroko Nakayama, Zhen Chen, Zi-jun Gao, Hitoshi Chiba, Shu-Ping Hui, Takahiko Aoki, Norihiro Nishimura, Yasuhito Shimada*†. Microbiome Alteration in Type 2 Diabetes Mellitus Model of Zebrafish. Sci. Rep. 2019;9:867.
33. Hiroko Nakayama†, Yasuhito Shimada*†, Liqing Zang, Masahiro Terasawa, Kaoru Nishiura, Koichi Matsuda, Charles Toombs, Chris Langdon and Norihiro Nishimura. Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models. Nutrients 2018, 10(10), 1401.
34. Liqing Zang, Lisette A. Maddison, Wenbiao Chen*. Zebrafish as a model for obesity and diabetes. Front Cell Dev Biol. 2018;6:91.
35. Zhen Chen†, Liqing Zang†, Yue Wu†, Hiroko Nakayama, Yasuhito Shimada, Rojeet Shrestha, Yaoyao Zhao, Yusuke Miura, Hitoshi Chiba*, Shu-Ping Hui*, Norihiro Nishimura. Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish. Anal Sci. 2018;34:1201-1208.
36. Liqing Zang*, Yasuhito Shimada, Norihiro Nishimura. Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. Sci. Rep. 2017; 7:1461.
37. Liqing Zang*, Yasuhito Shimada, Norihiro Nishimura. Effects of natural products on the diet-induced obesity zebrafish model. Journal of Japan Mibyo System Association. 2016; 22(2), 62-66.
38. Liqing Zang*, Yasuhito Shimada, Yuhei Nishimura, Toshio Tanaka, Norihiro Nishimura. Repeated blood collection for blood tests in adult zebrafish. J. Vis. Exp. 2015; (102):e53272.
39. Liqing Zang*, Yasuhito Shimada, Toshio Tanaka, Norihiro Nishimura. Rhamnan sulphate from Monostroma nitidum attenuates hepatic steatosis by suppressing lipogenesis in a diet-induced obesity zebrafish model. J. Funct. Foods. 2015, 17: 364-370
40. Liqing Zang*, Yasuhito Shimada, Jumpei Kawajiri, Toshio Tanaka, Norihiro Nishimura. Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model. J. Funct. Foods. 2014, 10:499-510.
41. Masanori Hiramitsu, Yasuhito Shimada, Junya Kuroyanagi, Takashi Inoue, Takao Katagiri, Liqing Zang, Yuhei Nishimura, Norihiro Nishimura, Toshio Tanaka*. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci. Rep. 2014, 15; 4:3708.
42. Noriko Umemoto, Yuhei Nishimura, Yasuhito Shimada, Yukiko Yamanaka, Seiya Kishi, Saki Ito, Kana Okamori, Yuuki Nakamura, Junya Kuroyanagi, Zi Zhang, Liqing Zang, Zhipeng Wang, Norihiro Nishimura, Toshio Tanaka*. Fluorescent-based methods for gene knockdown and functional cardiac imaging in zebrafish. Mol. Biotechnol. 2013, 55 (2):131-142.
43. Liqing Zang*, Yasuhito Shimada, Yuhei Nishimura, Toshio Tanaka, Norihiro Nishimura. A novel, reliable method for repeated blood collection from aquarium fish. Zebrafish. 2013, 10 (3):425-432.
44. Liqing Zang*, Daizo Morikane, Yasuhito Shimada, Toshio Tanaka, Norihiro Nishimura. A novel protocol for the oral administration of test chemicals to adult zebrafish. Zebrafish. 2011, 8 (4):203-210.
45. Toshiyuki Tainaka, Yasuhito Shimada, Junya Kuroyanagi, Liqing Zang, Takehiko Oka, Yuhei Nishimura, Norihiro Nishimura, Toshio Tanaka*. Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutr. Metab. 2011, 13; 8:88.
46. Takehiko Oka, Yuhei Nishimura, Liqing Zang, Minoru Hirano, Yasuhito Shimada, Zhipeng Wang, Noriko Umemoto, Junya Kuroyanagi, Norihiro Nishimura, Toshio Tanaka*. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiology. 2010, 21; 10:21.
47. Yasuhito Shimada, Hiroshi Tsunoda, Liqing Zang, Minoru Hirano, Takehiko Oka, Toshio Tanaka*. Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm. Eur. J. Pharmacol. 2009, 12; 620 (1-3):16-20.
48. Zhipeng Wang, Yuhei Nishimura, Yasuhito Shimada, Noriko Umemoto, Minoru Hirano, Liqing Zang, Takehiko Oka, Chikara Sakamoto, Junya Kuroyanagi, Toshio Tanaka*. Zebrafish beta-adorenergic receptor mRNA expression and control of pigmentation. Gene. 2009, 1; 446 (1):18-27.
49. Toshio Tanaka*, Takehiko Oka, Yasuhito Shimada, Noriko Umemoto, Junya Kuroyanagi, Chikara Sakamoto, Liqing Zang, Zhipeng Wang, Yuhei Nishimura. Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. J. Pharmacol. Sci. 2008, 107 (1):8-14.
50. Yoshiyuki Ito, Minoru Hirano, Noriko Umemoto, Liqing Zang, Zhipeng Wang, Takehiko Oka, Yasuhito Shimada, Yuhei Nishimura, Ichiro Kurokawa, Hitoshi Mizutani, Toshio Tanaka*. Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. BMB Reports. 2008, 29; 41 (2):139-145
51. Minoru Hirano, Liqing Zang, Takehiko Oka, Yoshiyuki Ito, Yasuhito Shimada, Yuhei Nishimura, Toshio Tanaka*. Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. Biochem. Biophys. Res. Commun. 2006, 8; 351 (1):185-191.
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